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Your search keyword '"Wang, Tianqing"' showing total 2 results
Start Over Author "Wang, Tianqing" Publisher elsevier
2 results on '"Wang, Tianqing"'

1. Photodynamic therapy for refractory erosive oral lichen planus: a case series study.

Author

Ming J, Yang Z, Wang T, Wang J, and Zeng X

Subjects
Humans, Aminolevulinic Acid therapeutic use, Adrenal Cortex Hormones therapeutic use, Treatment Outcome, Lichen Planus, Oral drug therapy, Lichen Planus, Oral pathology, Photochemotherapy adverse effects, Lichen Planus chemically induced, Lichen Planus drug therapy
Abstract

Oral lichen planus is a chronic inflammatory disease that occurs on the oral mucosa and is an oral potentially malignant disease. Treatment of oral lichen planus aims to promote healing of the erosion, relieve pain, reduce recurrence of the erosion, and prevent canceration. Corticosteroids are the first line of treatment for oral lichen planus. Refractory oral lichen planus is a clinical classification of oral lichen planus that has not responded to corticosteroid treatment for more than 2 months. Topical 5-aminolevulinic acid-mediated photodynamic therapy is an innovative and effective treatment for potentially malignant oral diseases and has been reported as an alternative treatment to conventional therapies for oral lichen planus. On this basis, we report 3 cases of refractory erosive oral lichen planus in which persistent erosive lesions healed after topical application of 5-aminolevulinic acid-mediated photodynamic therapy without any adverse effects or any signs of recurrence. Topical 5-aminolevulinic acid-mediated photodynamic therapy will become an effective clinical treatment for refractory erosive oral lichen planus., Competing Interests: Declaration of interest None., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Published
2024
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2. ICI-based therapies: A new strategy for oral potentially malignant disorders.

Author

Wang T, Sun S, Zeng X, and Li J

Subjects
Humans, Immune Checkpoint Inhibitors, Squamous Cell Carcinoma of Head and Neck drug therapy, B7-H1 Antigen metabolism, Receptors, Death Domain, Tumor Microenvironment, Carcinoma, Squamous Cell drug therapy, Mouth Neoplasms drug therapy, Mouth Neoplasms pathology, Mouth Diseases, Precancerous Conditions, Head and Neck Neoplasms
Abstract

Oral potentially malignant disorders (OPMDs) are linked with an escalated risk of developing cancers, particularly oral squamous cell carcinoma (OSCC). Since prevailing therapies cannot effectively forestall the exacerbation and recurrence of OPMDs, halting their malignant progression is paramount. The immune checkpoint serves as a cardinal regulator of the immune response and the primary cause of adaptive immunological resistance. Although the exact mechanism remains elusive, elevated expression of multiple immune checkpoints in OPMDs and OSCC relative to healthy oral mucosa has been ascertained. This review delves into the immunosuppressive microenvironment of OPMDs, the expression of diverse immune checkpoints such as programmed death receptor-1 (PD-1) and programmed death receptor-1 ligand (PD-L1) in OPMDs, and the potential application of corresponding inhibitors. In addition, synergistic strategies incorporating combined immune checkpoint inhibitors, such as cGAS-STING, costimulatory molecules, cancer vaccines, and hydrogels, are discussed to gain a more comprehensive understanding of the role and application of immune checkpoint inhibitors (ICIs) in oral carcinogenesis., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Published
2023
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