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Oxidative stress is one of the factors that promote melanogenesis. Trivalent iron ions play a key role in regulating the iron-catalysed oxidative stress response. A novel SERS flexible membrane sensor based on tannic acid with good sensitivity and uniformity was prepared by green in situ reduction of gold nanoparticles on bacterial cellulose membrane（BCM）with a simple and highly selective method to detect Fe 3+ . Under alkaline conditions, Fe 3+ is adsorbed on the BCM-TA@Au NPs flexible membrane by tannic acid (TA) through chelation, thus enabling the detection of Fe 3+ . Furthermore, this simple detection system has a wide linear detection range and high sensitivity to effortlessly evaluate Fe 3+ at concentrations up to 10 -7 M. More importantly, the proposed SERS flexible substrate performed well in determining Fe 3+ concentrations in B16 melanocytes, providing new insights into the factors affecting the melanin synthesis pathway and providing a potential biomarker for melanoma treatment., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)