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Graphene exhibits exceptional electrical properties, and aerogels made from it demonstrate high sensitivity when used in sensors. However, traditional graphene aerogels have poor biocompatibility and sustainability, posing potential environmental and health risks. Moreover, the stacking of their internal structures results in low compressive strength and fatigue resistance, which limits their further applications. In this study, green and sustainable cellulose nanofibers/sodium alginate/reduced graphene oxide aerogels (BCSRA) were synthesized, featuring a well-defined lamellar structure and a fiber cross-linked network, employing techniques such as bidirectional freeze-drying, ionic cross-linking, and thermal annealing. The unique internal architecture of BCSRA results in a compressive strength of up to 64.55 kPa at 70 % compression deformation and an extremely low density of merely 7.21 mg/cm 3 . Furthermore, BCSRA displays outstanding fatigue resistance, maintaining 82.17 % of its stress after 100 compression cycles at 70 % compressive strain and 86.99 % after 1000 cycles at 50 % compressive strain. Remarkably, when utilized as a flexible pressure sensor, BCSRA achieves a sensitivity of 5.71 kPa -1 and endures over 2200 cycles at 40 % compression, all while ensuring consistent electrical signal output. These properties underscore its significant potential for application in wearable flexible pressure sensors, capable of detecting various human movements., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier B.V. All rights reserved.)

Microplastics not only accumulate various harmful substances but also are ingested by marine organisms and humans, causing immeasurable impacts. Therefore, the removal of microplastics has become a crucial proposition for addressing the issue of microplastic pollution. This study investigated a bidirectional ordered graphene oxide (GO)/nanocellulose aerogels (D-DPGG) to remove microplastics from water bodies. The concentration of microplastics before and after adsorption was measured using a fluorescence spectrophotometer. D-DPGG aerogel exhibited excellent adsorption performance for microplastics (241.56 mg/g) and maintained high adsorption efficiency (>80 %) over 20 cycles of adsorption testing. Additionally, the link between GO and dual-directional treatment significantly improved the aerogel microstructure. It had an apparent layered structure in the transverse direction and improves the mechanical properties. D-DPGG aerogel not only served as an effective solution in adsorption but also held promise as a novel material in directional structural design., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Optical Coherence Tomography (OCT) facilitates a comprehensive examination of macular edema and associated lesions. Manual delineation of retinal fluid is labor-intensive and error-prone, necessitating an automated diagnostic and therapeutic planning mechanism. Conventional supervised learning models are hindered by dataset limitations, while Transformer-based large vision models exhibit challenges in medical image segmentation, particularly in detecting small, subtle lesions in OCT images. This paper introduces the Multidimensional Directionality-Enhanced Retinal Fluid Segmentation framework (MD-DERFS), which reduces the limitations inherent in conventional supervised models by adapting a transformer-based large vision model for macular edema segmentation. The proposed MD-DERFS introduces a Multi-Dimensional Feature Re-Encoder Unit (MFU) to augment the model's proficiency in recognizing specific textures and pathological features through directional prior extraction and an Edema Texture Mapping Unit (ETMU), a Cross-scale Directional Insight Network (CDIN) furnishes a holistic perspective spanning local to global details, mitigating the large vision model's deficiencies in capturing localized feature information. Additionally, the framework is augmented by a Harmonic Minutiae Segmentation Equilibrium loss (L HMSE ) that can address the challenges of data imbalance and annotation scarcity in macular edema datasets. Empirical validation on the MacuScan-8k dataset shows that MD-DERFS surpasses existing segmentation methodologies, demonstrating its efficacy in adapting large vision models for boundary-sensitive medical imaging tasks. The code is publicly available at https://github.com/IMOP-lab/MD-DERFS-Pytorch.git., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Frequent oil spills pose significant threats to ecosystems; therefore, strict requirements are needed for prompt remediation and reclamation of spilled oil. Influenced by the structure of coniferous trees and their water transport, this experiment used cellulose nanofiber (CNF), polyvinyl alcohol (PVA), and methyltrimethoxysilane (MTMS) to prepare radially centrosymmetric aerogels. By utilizing the in-situ polycondensation reaction of MTMS, CNF, and PVA were connected, and the hydrophobicity and mechanical properties of the aerogel were greatly enhanced. Furthermore, the introduction of graphene oxide (GO), enshrouded within the cross-linked network, engenders heightened photo-thermal effects. The resultant composite aerogel exhibits expeditious oil absorption under solar irradiation and radial layered channel architecture, significantly curtailing the crude oil absorption timeframe (achieving a maximum absorption capacity of 51.7 g/g). Moreover, it demonstrates superior performance in rapidly and repeatedly adsorbing highly viscous crude oil, surpassing existing literature. Notably, continuous absorption of high-viscosity crude oil is achieved by integrating the composite aerogel with a peristaltic pump. This study offers a novel approach to the absorption and retrieval of high-viscosity crude oil, broadening the potential application horizons of CNF-based aerogels within environmental remediation., Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Smart gating membranes have drawn much attention due to the controllable pore structure. Herein, a smart gating membrane with dual responsiveness was prepared from bacteria cellulose (BC) grafted with pH- and temperature-responsive polymers. By external stimulation, the average pore size of the membrane can be controlled from 33.75 nm to 144.81 nm, and the pure water flux can be regulated from 342 to 2118 L·m -2 ·h -1 with remarkable variation in the pH range of 1-11 and temperature range of 20-60 °C. The adjustability of pore size is able to achieve the gradient selective separation of particles and polymers with different sizes. In addition, owing to the underwater superoleophobicity and the nanoscale pore structure, the membrane separation efficiencies of emulsified oils are higher than 99 %. Moreover, the controllable pore size endows the membrane with good self-cleaning performance. This nanocellulose-based smart gating membrane has potential applications in the fields of controllable permeation, selective separation, fluid transport, and drug/chemical controlled release systems., Competing Interests: Declaration of competing interest We declare that we have no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Petroleum-based plastics are useful but they pose a great threat to the environment and human health. It is highly desirable yet challenging to develop sustainable structural materials with excellent mechanical and optical properties for plastic replacement. Here, we report a simple and efficient method to manufacture high-performance all-biobased structural materials from cellulosic wood skeleton (WS) and gelatin via oxidation and densification. Specifically, gelatin was grafted to the oxidized cellulose wood skeletons (DAWS) and then physically crosslinked via Tannic acid (TA), resulting in a significant enhancement of the material properties. Notably, only a mild pressure was applied during the drying process to form a densified TA/Gelatin/transparent wood film(TWF). The developed TA/Gelatin/TWF (thickness:100 ± 12 μm) exhibited a desirable combination of high strength (∼154.59 MPa), light transmittance (86.2 % at 600 nm), low haze (16.7 %), high water stability (wet strength: ∼130.13 MPa) and ultraviolet blocking efficacy which surpass most of the petroleum-based plastics. In addition, due to the all bio-based origins (wood and gelatin), TA/Gelatin/TWF are easily biodegradable under natural conditions, leading to less impact on the environment. These findings would hold promises for exploring high-quality all bio-based wood composites as eco-friendly alternatives to substitute plastics with wide applications, e.g. anti-counterfeiting, UV protection, and flexible electricals., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Recent reports had shown that microplastics could be transferred to organisms through various channels, severely and adversely affecting organisms' health and their physiological functions. Therefore, there remained an urgency to adopt an effective and environmentally friendly method to extract microplastics from water. In this paper, a cationic-modified d-DCPG aerogel with a three-dimensional network structure was successfully prepared by a directional freeze-drying technology in which double-aldehyde-modified cellulose nanofiber (CNF) was used as the matrix, betaine chloride hydrazide (GT) provided modification, and polyvinyl alcohol (PVA) provided cross-linking function. Aerogels had an excellent adsorption capacity (145.05 mg/g) for microplastics in aqueous environment, and when the pH was from 10 to 4, it exhibited an excellent adsorption efficiency from 90.01 % to 97.61 %; an excellent adsorption efficiency after 8 cycles (>89 %); pseudo-second-order kinetics and Freundlich adsorption isotherm had a high fitting effects on the adsorption process and adsorption results, respectively. And ultraviolet analysis also verified the occurrence of adsorption behavior. These results showed that d-DCPG aerogels had an excellent application prospects in microplastics removal in river, lake, reservoir, and marine environments., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The ultraviolet (UV) blocking performance of current bio-based devices is always limited by delignification and exploited chemical treatment. Lignocellulosic nanofibril (LCNF) is a promising green alternative that could efficiently impede UV radiation. Herein, we proposed a robust LCNF film that achieved 99.8 ± 0.19 % UVB blocking, 96.1 ± 0.23 % UVA blocking, and was highly transparent without complex chemical modification. Compared to conventional lignin composites, this LCNF method involves 29.5 ± 2.31 % lignin content directly extracted from bamboo as a broad-spectrum sun blocker. This bamboo-based LCNF film revealed an excellent tensile strength of 94.9 ± 3.6 MPa and outstanding stability, adapting to the natural environment's variability. The residual hemicellulose could also embed the link between lignin and cellulose, confirming high lignin content in the network. The connection between lignin and hemicelluloses in the cellulose network was explored and described for the fibrillation of lignocellulosic nanofibrils. This research highlights the promising development of LCNFs for UV protection and bio-based solar absorption materials., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Objective: To provide a precise description of the morphology and morphometry of the hypoglossal canal (HC) and its relationship with surrounding structures by using the epoxy sheet plastination technique., Methods: Thirty human cadaveric heads were plastinated into 5 sets of gross transparent plastination slices and 43 sets of ultrathin plastination sections. The HC were examined at both macro- and micro levels in these plastination sections and the reconstructed 3-dimensional visualization model., Results: The HC was an upward arched bony canal with a dumbbell-shaped lumen. According to the arched trajectory of its bottom wall, the HC could be divided into a medial ascending segment and a lateral descending segment. The thickness of the compact bone in the middle part of the HC was thinner than that at the intracranial and extracranial orifices. In 14 of 43 sides (32.6%), the posterior wall or the roof of the HC were disturbed by passing venous channels which communicated the posterior condylar emissary vein and the inferior petroclival vein. The trajectory of hypoglossal nerve in HC is mainly from anterosuperior to posteroinferior. The meningeal dura and the arachnoid extended into the HC along the hypoglossal nerve to form the dural and arachnoid sleeves and then fused with the nerve near the extracranial orifice of the HC., Conclusions: Knowledge of the detailed anatomy of the HC can be helpful in avoiding surgical complications when performing surgery for lesions and the occipital condylar screw placement in this complex area., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Conductive hydrogels are considered one of the most promising materials for preparing flexible sensors due to their flexible and extensible properties. However, conventional hydrogels' weak mechanical and isotropic properties are greatly limited in practical applications. Here, the internal structure of the hydrogel was regulated by pre-stretching synergistic ion crosslinking to construct a carboxymethyl cellulose-based double network-oriented hydrogel similar to muscle. The introduction of pre-stretching increased the tensile strength of the double-network hydrogel from 1.45 MPa to 4.32 MPa, and its light transmittance increased from 67.3 % to 84.5 %. In addition, the hydrogel's thermal stability and electrical conductivity were improved to a certain extent. Its good mechanical properties and conductive properties can be converted into stable electrical signal output during deformation. The carboxymethyl cellulose-based double network oriented hydrogels were further assembled as flexible substrates into flexible sensor devices. The hydrogel sensors can monitor simple joint movements as well as complex spatial movements, which makes them have potential application value in the research field of intelligent response electronic devices such as flexible wearables, intelligent strain sensing, and soft robots., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

A smart gating membrane based on thermal-sensitive poly (N-isopropyl acrylamide) (PNIPAM)-grafted nanocellulose and carbon nanotube (CNT) was prepared. The presence of PNIPAM shell on cellulose nanofibrils (CNFs) endow the composite membrane with thermal responsiveness. By external stimulation, an increase temperature from 10 °C to 70 °C allows the average pore size of the membrane to be controlled from 28 nm to 110 nm, as well as the water permeance from 440 L·m -2 ·h -1 ·bar -1 to 1088 L·m -2 ·h -1 ·bar -1 . The gating ratio of the membrane can reach 2.47. The photothermal effect of CNT rapidly warms up the membrane to the lowest critical solution temperature in the water, avoiding the constraint that the whole water phase cannot be heated throughout the practical use process. The membrane can precisely control the nanoparticles to concentrate at 25.3 nm, 47.7 nm or 102 nm by adjust the temperature. In addition, the water permeance can be restored to 370 L·m -2 ·h -1 ·bar -1 by washing the membrane under light. The smart gating membrane has a wide application in substance multi-stage separation and selective separation, and it can realize self-cleaning., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Currently, cellulose-based aerogel materials are a hot topic owing to their high specific surface area and high porosity, as well as the green, degradable and biocompatible characteristics of cellulosic materials. Modification of cellulose to enhance the adsorption properties of cellulose-based aerogels has important research significance in solving the problem of water body pollution. In this paper, cellulose nanofibers (CNFs) were modified with polyethyleneimine (PEI), and modified aerogels with directional structures were prepared by a simple reaction and freeze-drying method. The adsorption behavior of the aerogel followed the adsorption kinetic models and isotherm models. More significantly, the aerogel could rapidly adsorb microplastics, reaching equilibrium within 20 min. Furthermore, the fluorescence displayed directly expresses the occurrence of the adsorption behavior of the aerogels. Therefore, the modified cellulose nanofiber aerogels were of reference significance for microplastic removal from water bodies., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Anisotropic hydrogels have attracted extensive attention because they are similar to natural hydrogel-like materials and exhibit superiority and new functions that isotropic hydrogels cannot. Here, we fabricated strong and tough carboxymethyl cellulose-based conductive hydrogels with oriented hierarchical structures through pre-stretching, solvent displacement induced phase separation, and subsequent ionic crosslinking immobilization. Solvent displacement made the pre-stretched carboxymethyl cellulose-based polymer network more dense and linear, while the toughness of the hydrogel was further improved under the effect of phase separation. Strong and tough hydrogels were prepared by combining pre-stretching and phase separation; the variation range (tensile strength of 2.24-6.19 MPa and toughness of 19.41-22.92 MJ/m 3 ) can be adjusted by the stretching ratio. Compared with traditional carboxymethyl cellulose-based hydrogels, the tensile strength and toughness were increased by 49 times and 15 times, respectively. In addition, the hydrogels had good underwater stability, ion cross-linking made the hydrogels have good conductivity, and the directional stratification structure gave the hydrogels conductive anisotropy. These characteristics give hydrogel sensors broad application prospects in flexible wearable devices, anisotropic sensors, and intelligent underwater devices., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Oil spills frequently occur in the ocean, and adsorption is one of the effective ways to deal with oil spills. Compared with other adsorbent materials, biomass aerogel has superior selective adsorption capacity. CNF/SA aerogels with good mechanical properties (340 kPa at 90 % strain) and high adsorption capacity (88.91 g/g) were prepared by mixing cellulose nanofibers (CNF) with sodium alginate (SA) through bidirectional freeze-drying, ionic crosslinking, and surface modification to effectively solve the ocean oil spill problem. The bidirectional freeze-drying technology is a green and efficient technique for preparing layered microstructured composite aerogels. The prepared aerogels have a three-dimensional interpenetrating lamellar structure, low density (24.2 mg/cm 3 ), high porosity (97.85 %), and high hydrophobicity (WCA = 144.5°), can be calibrated and used repeatedly. It has potential applications in water-oil separation and can be used as an absorbent for effectively treating oil spills in the ocean environment., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Background: The anatomy and spatial relationships of the dural sac comprising the Meckel cave (MC) and its ensheathed trigeminal ganglion (TG) are exceedingly intricate and complex. There are conflicting accounts in the literature regarding the dural configuration of the MC around the ganglion and the dual embryology of the MC and TG is still unclear., Methods: A combined systematic and narrative literature review was conducted to collate articles addressing MC and TG anatomy, in addition to their embryology, role in tumor spread, somatotopy, and association with trigeminal neuralgia., Results: Three key anatomic models by Paturet (1964), Lazorthes (1973), and Lang and Ferner (1983) have been put forward to show the arrangement of the MC around the TG. The TG is formed from both neural crest and placodal cells and drags the enveloping dura caudally to form the MC prolongation during development. Both a mediolateral and dorsoventral somatotopic arrangement of neurons exists in the TG, which corresponds to the 3 nerve divisions, of which V2 and V3 are prone to perineural tumor spread along their course., Conclusions: Sound knowledge concerning the dural arrangement of the MC and the trigeminal divisions will be invaluable in optimally treating cancers in this region, and understanding TG somatotopy will immensely improve treatment of trigeminal neuralgia in terms of specificity, efficacy, and positive patient outcomes., (Copyright © 2021 Elsevier Inc. All rights reserved.)

In increasingly serious marine pollution environment, environmentally friendly low-density aerogels have become potential oil-water separation materials. However, many reported aerogels have the drawbacks of low oil absorption, poor compressibility and flexibility, which limit their application. Herein, we reported a compressible, anisotropic lamellar hydrophobic and lipophilic graphene/polyvinyl alcohol/cellulose nanofiber carbon aerogel (a-GPCCA) prepared by directional freeze-drying and carbonization processes. The synthetic ultralight a-GPCCA had low density (6.17 mg/cm 3 ) and high porosity (99.61 %). Moreover, directional freeze-drying resulted in a lamellar interpenetrated three-dimensional porous structure, which endowed it with high adsorption capacity (155-288 times of its weight), good compressibility (95 % recovery after repeating 15 cycles at 50 % strain in parallel to the freezing direction) and recyclability (oil retention rate reached 88.8 % after 10 absorption-compression cycles). Furthermore, carbonization provided it with excellent thermal stability and hydrophobic properties, resulting in oil-water selectivity and combustion cyclicity (the oil absorption capacity was reduced by only 10.2 % after 10 absorption-combustion cycles). Therefore, the a-GPCCA obtained in this study possesses a promising potential in the field of treatment of offshore oil spills and domestic industrial wastewater., Competing Interests: Declaration of Competing Interest There are no conflicts of interest., (Copyright © 2019 Elsevier B.V. All rights reserved.)