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2 results on '"Xue-Jun Qin"'

1. Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease

Author

Pu-Ting Xu, Yi-Ju Li, Xue-Jun Qin, Clemens R. Scherzer, Hong Xu, Donald E. Schmechel, Christine M. Hulette, John Ervin, Steven R. Gullans, Jonathan Haines, Margaret A. Pericak-Vance, and John R. Gilbert

Subjects
Apolipoprotein E, Alzheimer disease, Gene expression, Microarray, Apoptosis, Signal pathways, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Apolipoprotein E4 (APOE4) allele is a major risk factor for late-onset familial and sporadic Alzheimer disease (AD). The mechanism of action of APOE in the etiology of AD remains unclear. Using gene expression (microarray) analysis of human hippocampus from APOE3/3 AD and APOE4/4 AD cases, we found different gene transcription patterns between APOE4/4 and APOE3/3 AD cases. The expression of APOE4/4 alleles, in comparison to APOE3/3, is associated with upregulation of multiple gene transcripts encoding cell growth suppresser or arrest, signal transduction, myelinogenesis, cell adhesion and migration, heavy metal metabolism and detoxification. Whereas the APOE4 gene expression is associated with downregulation of gene transcripts involved in mitochondrial oxidative phosphorylation and energy metabolism, synaptic vesicle docking and fusing, and synaptic plasticity compared to APOE3. These mechanisms may contribute increased risk for AD and for cognitive dysfunction in AD patients who carry the APOE4 allele(s).

Published
2006
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2. Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease

Author

Hong Xu, Christine M. Hulette, Steven R. Gullans, Jonathan L. Haines, Clemens R. Scherzer, Margaret A. Pericak-Vance, Donald E. Schmechel, John R. Gilbert, Yi-Ju Li, Xue Jun Qin, Pu Ting Xu, and John F. Ervin

Subjects
Apolipoprotein E, Male, Apolipoprotein B, Genotype, Transcription, Genetic, Apoptosis, Microarray, Hippocampus, lcsh:RC321-571, Apolipoproteins E, Synaptic vesicle docking, Risk Factors, Signal pathways, Gene expression, mental disorders, Humans, Allele, Gene, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Alleles, In Situ Hybridization, Aged, Oligonucleotide Array Sequence Analysis, Genetics, Aged, 80 and over, Metal metabolism, biology, Neurology, biology.protein, Female, lipids (amino acids, peptides, and proteins), Signal transduction, Alzheimer disease, human activities, Software
Abstract

Apolipoprotein E4 (APOE4) allele is a major risk factor for late-onset familial and sporadic Alzheimer disease (AD). The mechanism of action of APOE in the etiology of AD remains unclear. Using gene expression (microarray) analysis of human hippocampus from APOE3/3 AD and APOE4/4 AD cases, we found different gene transcription patterns between APOE4/4 and APOE3/3 AD cases. The expression of APOE4/4 alleles, in comparison to APOE3/3, is associated with upregulation of multiple gene transcripts encoding cell growth suppresser or arrest, signal transduction, myelinogenesis, cell adhesion and migration, heavy metal metabolism and detoxification. Whereas the APOE4 gene expression is associated with downregulation of gene transcripts involved in mitochondrial oxidative phosphorylation and energy metabolism, synaptic vesicle docking and fusing, and synaptic plasticity compared to APOE3. These mechanisms may contribute increased risk for AD and for cognitive dysfunction in AD patients who carry the APOE4 allele(s).

Published
2006

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