Search

Objective: The effect of surgical clipping (SC) and endovascular coiling (EC) on the incidence of delayed cerebral ischemia (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH) has always been a controversial topic. Hence, it is necessary to reanalyze the effects of the 2 surgical methods on DCI, which determines the choice of the most favorable method for patients who are suitable for both surgical modalities., Methods: A multicenter retrospective observational cohort study was performed to evaluate all consecutive patients with aSAH admitted to 5 medical centers in China between April 2019 and June 2021. Univariable and multivariable analyses were used to confirm risk factors of DCI after aSAH. A 1:1 propensity score matching model was generated in the EC and SC groups to reduce the influence of all confounding factors on DCI., Results: A total of 412 patients were included, and 115 patients (27.9%) developed DCI. After propensity score matching for controlling demographic information, past medical history, admission clinical status, aneurysm characteristics, and inflammatory factors associated with DCI, 133 patients with SC and 133 patients with EC treatment were matched. The results of the matched cohorts indicate a significantly lower incidence of DCI when patients received EC than SC (31.9% vs. 20%; adjusted odds ratio, 1.87; 95% confidence interval, 1.08-3.29; P = 0.027)., Conclusions: The study found that the patients who received SC treatment had a higher incidence of DCI than did those who received EC and suggested that ruptured intracerebral aneurysm is preferentially coiled rather than clipped if the aneurysm is suitable for both surgical modalities., (Copyright © 2023. Published by Elsevier Inc.)

Glioblastoma multiforme (GBM) is the intracranial malignancy with the highest rates of morbidity and mortality. Chemotherapy is often ineffective against GBM due to the presence of the blood-brain barrier (BBB); however, the application of nanotechnology is expected to overcome this limitation. Poly(lactic-co-glycolic acid) (PLGA) is a degradable and nontoxic functional polymer with good biocompatibility that is widely used in the pharmaceutical industry. Previous studies have shown that the ability of PLGA nanoparticles (NPs) to penetrate the BBB is largely determined by their size; however, determination of the optimal PLGA NP size requires further research. Here, we report a tandutinib-based prodrug (proTan), which responds to the GBM microenvironment, that was combined with NPs to overcome the BBB. AMD3100-PLGA NPs loaded with proTan inhibited tumor growth and effectively prolonged the survival of tumor-bearing mice., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier Inc.)

Background: It has been reported that HOXA transcript at the distal tip (HOTTIP) is dysregulated in various cancers. We performed this meta-analysis to clarify its promising functions as a prognosis marker in malignant tumors., Methods: The electronic databases, including PubMed, Medline, OVID, Cochrane Library, and Web of Science were searched from inception to September 23, 2016. The hazard ratio (HR) and 95% confidence interval (CI) were calculated to explore the relationship between HOTTIP expression and overall survival (OS), which were extracted from the eligible studies. The odds ratio (OR) was calculated to assess the association between HOTTIP expression and pathological parameters by using RevMan5.3 software., Results: Seven studies were included in the study, with a total of 652 patients. The pooled HR suggested that high HOTTIP expression was significantly correlated with poor OS (HR=2.16, 95% CI: 1.69-2.76, P<0.00001) in cancer patients without obvious heterogeneity. The results showed there was a significant difference in the incidence of lymph node metastasis (LNM) between high HOTTIP expression group and low HOTTIP expression group (OR=2.30, 95% CI: 1.58-3.35, P<0.0001). A similar result was observed in the association between HOTTIP expression and distant metastasis (DM), the odds ratio was 3.30 (95% CI: 1.78-6.12, P=0.0001) without obvious heterogeneity. In addition, high HOTTIP expression was significantly associated with high tumor stage (OR=3.30, 95% CI: 0.25-0.64) without heterogeneity., Conclusions: This meta-analysis demonstrated that high HOTTIP expression significantly predicts poor OS, lymph node metastasis, distant metastasis and tumor stage, suggesting that high HOTTIP expression may serve as a novel biomarker for poor prognosis in cancers., (Copyright © 2017 Elsevier B.V. All rights reserved.)