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Here, the Sr 2 LaNbO 6 : Yb 3+ /Nd 3+ /Ho 3+ phosphors are prepared through solid-state route. The upconversion (UC)/downshifting (DS) luminescence and temperature performances of all samples are investigated in detail. Under 808 nm excitation, the infrared emission band (∼2000 nm) of Ho 3+ ions is obtained. Especially, the energy transfer process of Nd 3+  → Yb 3+  → Ho 3+ has increased the emission intensity of ∼2000 nm. Moreover, the infrared emission band presents thermal enhancement. Under 980 nm excitation, the UC emission band 500-960 nm is investigated. The green and red light of Ho 3+ ion, near infrared light of Nd 3+ ions are achieved. In addition, the possible luminescence mechanism of Sr 2 LaNbO 6 : Yb 3+ /Nd 3+ /Ho 3+ phosphor is discussed. At last, the optical temperature sensing characteristics of the phosphor are studied according to the luminescence intensity ratio (LIR) technology. The maximum relative sensitivity of Sr 2 LaNbO 6 : Yb 3+ /Nd 3+ /Ho 3+ reaches 5.476 % K -1 at 293 K. These results prove that the Sr 2 LaNbO 6 : Yb 3+ /Nd 3+ /Ho 3+ phosphor presents the luminescence in infrared and visible range. The Sr 2 LaNbO 6 :Yb 3+ /Nd 3+ /Ho 3+ phosphor also can be applied to design optical temperature sensor., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

This is the first prospective study of treatment of patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive hematologic malignancy derived from plasmacytoid dendritic cells that typically involves the skin and rapidly progresses to a leukemia phase. Despite being initially responsive to intensive combination chemotherapy, most patients relapse and succumb to their disease. Because BPDCN blasts overexpress the interleukin-3 receptor (IL3R), the activity of SL-401, diptheria toxin (DT)388IL3 composed of the catalytic and translocation domains of DT fused to IL3, was evaluated in BPDCN patients in a phase 1-2 study. Eleven patients were treated with a single course of SL-401 at 12.5 μg/kg intravenously over 15 minutes daily for up to 5 doses; 3 patients who had initial responses to SL-401 received a second course in relapse. The most common adverse events including fever, chills, hypotension, edema, hypoalbuminemia, thrombocytopenia, and transaminasemia were transient. Seven of 9 evaluable (78%) BPDCN patients had major responses including 5 complete responses and 2 partial responses after a single course of SL-401. The median duration of responses was 5 months (range, 1-20+ months). Further studies of SL-401 in BPDCN including those involving multiple sequential courses, alternate schedules, and combinations with other therapeutics are warranted. This trial is registered at clinicaltrials.gov as #NCT00397579., (© 2014 by The American Society of Hematology.)

Castor is a zinc finger transcription factor that controls cell fate within neuroblast cell lineages in Drosophila melanogaster. Here, we describe the cloning and characterization of a human castor gene (CASZ1) that is structurally homologous to Drosophila castor. We find the expression of castor gene is increased when cells of neural origin as well as mesenchymal origin are induced to differentiation. CASZ1 is expressed in a number of normal tissues and exists in at least two mRNA species of 4.4 and 8.0kb. They are named hCasz5 and hCasz11 because the predicted proteins have 5 and 11 zinc fingers, respectively. Deletion analysis of the proximal 5'-flanking sequences delineates sequences sufficient to drive transcription in cells of neural and non-neural origin. Both hCasz5 and hCasz11 localize predominantly in the nucleus, consistent with their role as Zn-finger containing transcription factor. CASZ1 is expressed in a number of human tumors and localizes to a chromosomal region frequently lost in tumors of neuroectodermal origin.