Search

Your search keyword '"Yossi Gilgun-Sherki"' showing total 2 results
Start Over Author "Yossi Gilgun-Sherki" Publisher elsevier
2 results on '"Yossi Gilgun-Sherki"'

1. Contributors

Author

Galip Agaoglu, Margarita L. Alexandrova, Gjumrakch Aliev, Michael Aschner, Agnieszka Augustyniak, C. Barriga, Carlo Valerio Bellieni, Daniela Berg, Petyo G. Bochev, Giuseppe Buonocore, D. Allan Butterfield, Vittorio Calabrese, Maria Teresa Carrì, Gemma Casadesus, Piu Chan, K. Christou, Fabio Coppedè, Mauro Cozzolino, P.J. Crack, J. Cubero, J.B. de Haan, Carlo De Marco, Luisa De Marco, Giuseppe Di Giovanni, Vincenzo Di Matteo, Allison W. Dobson, Ennio Esposito, Carlos Kusano Bucalen Ferrari, Harold D. Foster, Yossi Gilgun-Sherki, Anna Maria Giuffrida Stella, K.I. Gourgoulianis, E. Grünblatt, Glenda Halliday, Kenneth Hensley, Abram Hoffer, Kazuhiro Honda, Yue Huang, Kurt A. Jellinger, I. Kola, Yalcin Kulahci, Brett C. Langley, Nirit Lev, Wojciech Łuczaj, Cesare Mancuso, S. Mandel, Eldad Melamed, Molina Mhatre, Lucia Migliore, Paula I. Moreira, Thomas Müller, D. Narciso, Akihiko Nunomura, Daniel Offen, Justyna Ostrowska, S.D. Paredes, S.H. Parvez, Evelyn Perez, Serafina Perrone, George Perry, Massimo Pierucci, M.A. Pritchard, G. Ali Qureshi, P. Riederer, M.E.C. Robbins, A.B. Rodríguez, S. Sánchez, Maria Siemionow, James W. Simpkins, Elzbieta Skrzydlewska, Mark A. Smith, Tuck Wah Soong, Shuja Ali Syed, M.P. Terrón, Fai Tsang, Nicole von Wurmb-Schwark, Peter C. Waldmeier, Xiaofei Wang, M.B.H. Youdim, W. Zhao, and Xiongwei Zhu

Published
2007
Full Text
View/download PDF

2. The Role of Oxidative Stress in the Pathogenesis of Multiple Sclerosis: Current State

Author

Yossi Gilgun-Sherki, Eldad Melamed, Daniel Offen, and Nirit Lev

Subjects
chemistry.chemical_classification, Reactive oxygen species, Antioxidant, medicine.medical_treatment, Multiple sclerosis, Experimental autoimmune encephalomyelitis, Central nervous system, Biology, medicine.disease, medicine.disease_cause, Pathogenesis, medicine.anatomical_structure, chemistry, Immunology, medicine, Demyelinating disease, Oxidative stress
Abstract

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS), often beginning in late adolescence and early adult life. The etiology of MS has not yet been fully elucidated, and it is attributed to both genetic and environmental causes. Accumulating data indicate that oxidative stress (OS) plays a major role in the pathogenesis of MS. Reactive oxygen species (ROS), leading to OS, generated in excess primarily by macrophages, have been implicated as mediators of demyelination and axonal damage in both MS and its animal model: experimental autoimmune encephalomyelitis (EAE). ROS cause damage to cardinal cellular components such as lipids, proteins, and nucleic acids, thereby resulting in cell death. Weakened cellular antioxidant defense systems in the CNS of MS patients resulting in increased vulnerability to ROS effects may increase CNS damage. This chapter reviews the current knowledge on OS in MS and possible antioxidant treatments.

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results