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This study aimed to evaluate the histopathological changes in the aorta and kidneys of mice age of menopause by the ethanol extract of ylang-ylang (Cananga odorata) flowers. Thirty female age of menopause mice was divided into three groups (n = 10 each group), consisting of a group of mice the age of menopause without any treatment, mice age of menopause treated with different dosages of ylang-ylang flower extract (0.1 mg/day and 0.2 mg/day). Histopathological analysis was performed with hematoxylin-eosin staining. The number of endothelial cells and the thickness of the intima in the group treated with high dose of the extract were significantly higher than the lowest dose of the extract or the control group (p