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Start Over Author "Yuto Abe" Publisher elsevier
3 results on '"Yuto Abe"'

1. Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity

Author

Yusuke Kamiya, Hiroka Takaku, Rio Yamada, Chisato Akase, Yuto Abe, Yuko Sekiguchi, Norie Murayama, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, and Hiroshi Yamazaki

Subjects
Caco-2 cells, Octanol–water distribution coefficient, Multivariate prediction equation, Fraction absorbed, No-observed-effect level, Toxicology. Poisons, RA1190-1270
Abstract

Apparent permeability coefficients (Papp) across a human intestinal epithelial Caco-2 cell monolayer were measured for a range of industrial/drug chemicals. A predictive equation for determining in vitro Papp values of fifty-six substances was set up using multivariate regression analysis based on in silico-estimated physicochemical properties (molecular weights and water distribution coefficients for apical and basal pH environments) (r = 0.77, p

Published
2020
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2. Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity

Author

Yuto Abe, Makiko Shimizu, Masato Kitajima, Hiroka Takaku, Norie Murayama, Chisato Akase, Fumiaki Shono, Hiroshi Yamazaki, Yusuke Kamiya, Kimito Funatsu, Rio Yamada, and Yuko Sekiguchi

Subjects
Drug, Apparent permeability, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Cell, 010501 environmental sciences, Toxicology, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, lcsh:RA1190-1270, Monolayer, medicine, Caco-2 cells, lcsh:Toxicology. Poisons, 0105 earth and related environmental sciences, media_common, ComputingMethodologies_COMPUTERGRAPHICS, Molecular mass, Chemistry, Fraction absorbed, Regular Article, In vitro, Epithelium, No-observed-effect level, medicine.anatomical_structure, Biochemistry, Multivariate prediction equation, Octanol–water distribution coefficient, 030217 neurology & neurosurgery
Abstract

Graphical abstract, Highlights • Permeability values of 90 industry chemicals were measured by a Caco-2 system. • A multivariate prediction equation for permeability of chemicals was proposed. • Chemical permeability coefficients were inversely associated with hepatic NOELs., Apparent permeability coefficients (Papp) across a human intestinal epithelial Caco-2 cell monolayer were measured for a range of industrial/drug chemicals. A predictive equation for determining in vitro Papp values of fifty-six substances was set up using multivariate regression analysis based on in silico-estimated physicochemical properties (molecular weights and water distribution coefficients for apical and basal pH environments) (r = 0.77, p

Published
2020

3. Piperine-hydroxybenzoate as phytochemistry antiosteoarthritis combination: Structural, solubility, and in vivo antiinflammatory study

Author

Ari Sartinah, Hidehiro Uekusa, Yuto Abekura, Slamet Ibrahim, Kusnandar Anggadiredja, and Ilma Nugrahani

Subjects
Solid-phase multicomponent, Piperine, 4-Hydroxybenzoic acid, Piperine-hydroxybenzoate, Antiosteoarthritis, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

This study discusses the composition and structure determination of a new multicomponent system from antiinflammatory natural ingredients, consisting of piperine (Pip) and 4-hydroxybenzoic acid (HBA), named Pip-HBA. In addition, this research studied its solubility and anti-inflammatory activity. After screening the stoichiometric proportions, this multicomponent system formation reaction was carried out using the solvent-dropped grinding and evaporation methods. Characterizations using solid analysis including differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR), confirmed the formation of Pip-HBA. These multicomponent systems showed different thermograms and diffractograms. Furthermore, the FTIR spectrum of Pip-HBA multicomponent system differs from the physical mixture and its constituent components. Single crystal diffractometry (SCXRD) determined Pip-HBA to be a new multicomponent system structure in three dimensions. Pip-HBA showed increased solubility and anti-inflammatory activity compared to single piperine. Therefore, Pip-HBA multicomponent system has quite potential for further preparation development.

Published
2024
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