1. Advances in SPECT Methodology
- Author
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Sabina Pappatà, Emilia Zampella, Roberta Assante, Alberto Cuocolo, Cuocolo A, Pappatà S, Zampella E, Assante R, Cuocolo, Alberto, Pappata', Sabina, Zampella, Emilia, and Assante, Roberta
- Subjects
Movement disorders ,Dopaminergic system ,Molecular imaging ,Single-photon emission computed tomography ,Abnormal protein ,030218 nuclear medicine & medical imaging ,Cellular and Molecular Neuroscience ,03 medical and health sciences ,0302 clinical medicine ,Neurochemical ,Medicine ,Semiquantitative analysi ,Reconstruction algorithm ,medicine.diagnostic_test ,business.industry ,Cerebral blood flow ,Molecular targets ,Neurology (clinical) ,medicine.symptom ,business ,Metabolic activity ,Neuroscience ,030217 neurology & neurosurgery ,Emission computed tomography - Abstract
The emerging role of molecular imaging has made possible to evaluate and quantify biochemical changes of molecular targets in specific neurochemical systems involved in movement disorders, providing neurochemical information of clinical changes before the pathological features occurred. In detail, radionuclides imaging techniques are frequently used for the in vivo study of neurotransmitter and receptor function, alterations in cerebral blood flow and metabolic activity, abnormal protein deposition, and inflammation, with a central role in molecular imaging for preclinical and clinical studies. The present chapter represents an overview of main use of single-photon emission computed tomography (SPECT) in movement disorders, with a focal attention on specific radiotracers used, recent advances in SPECT technology and reconstruction algorithm and added specific value of semiquantitative methods for images analysis. Finally, a brief paragraph is dedicated to description of SPECT/CT devices and advantages of using hybrid technology.
- Published
- 2018