1. Eudesmane sesquiterpenoid glycosides from the leaves of Pittosporum lenticellatum with anti-neuroinflammatory activity.
- Author
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Zhang Q, Zhang Y, Guan S, Fang X, Liu X, Gao J, and Zhang X
- Subjects
- Molecular Structure, Molecular Docking Simulation, Magnetic Resonance Spectroscopy, Nitric Oxide, Glycosides pharmacology, Sesquiterpenes, Eudesmane pharmacology, Sesquiterpenes, Eudesmane chemistry, Sesquiterpenes chemistry
- Abstract
Chemical investigation of the EtOAc extract of the leaves of Pittosporum lenticellatum led to the isolation of twenty-five previously undescribed eudesmane sesquiterpenoid glycosides, pitlencosides A－Y (1-25); their structures were elucidated by extensive spectroscopic analysis, including 1D and 2D NMR, HR-ESI-MS, ECD spectra, and X-ray crystallographic analysis. Among them, compounds 4, 5, 7, 8, 15 and 16 exhibited significant inhibitory effects on the production of nitric oxide in lipopolysaccharide-induced BV-2 microglial cells by suppressing the expression of inducible nitric oxide synthase and cyclooxygenase-2, with IC
50 values ranging from 7.95 to 25.88 μM, which showed stereo-chemical and substituent dependents. Western blot analysis and molecular docking simulation confirmed the anti-inflammatory activity of compounds 4, 5, 7, 8, 15 and 16., Competing Interests: Declaration of competing interest The authors declare no competing financial interest., (Copyright © 2023 Elsevier Ltd. All rights reserved.)- Published
- 2023
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