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Microplastics (MPs) are pervasive across ecosystems, presenting substantial risks to human health. Developing a comprehensive review of MPs is crucial due to the growing evidence of their widespread presence and potential harmful effects. Despite the growth in research, considerable uncertainties persist regarding their transport dynamics, prevalence, toxicological impacts, and the potential long-term health effects they may cause. This review thoroughly evaluates recent advancements in research on MPs and their implications for human health, including estimations of human exposure through ingestion, inhalation, and skin contact. It also quantifies the distribution and accumulation of MPs in various organs and tissues. The review discusses the mechanisms enabling MPs to cross biological barriers and the role of particle size in their translocation. To ensure methodological rigor, this review adheres to the PRISMA guidelines, explicitly detailing the literature search strategy, inclusion criteria, and the quality assessment of selected studies. The review concludes that MPs pose significant toxicological risks, identifies critical gaps in current knowledge, and recommends future research directions to elucidate the prolonged effects of MPs on human health. This work aims to offer a scientific framework for mitigating MP-related hazards and establishes a foundation for ongoing investigation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

The potential deleterious effects of microplastics on environmental integrity and human health have elicited global attention. Particularly vulnerable to microplastics are Danxia landforms, characterized by their unique topographical features and ecologically fragile milieu. Notwithstanding, empirical studies assessing the prevalence of microplastics in these unique landforms remain strikingly limited. The present investigation comprehensively examined the abundance of microplastics in surface water, sediment, and groundwater across six cities and six counties within the Danxia landforms. Comparative analysis revealed a moderate level of microplastic contamination in the urban rivers of the Danxia region relative to other freshwater rivers. Anthropogenic activities, notably urban wastewater treatment and tourism, emerged as principal contributors to microplastic pollution. Sedimentary microplastics exhibited an accumulative trend from upstream to downstream locations. The risk assessment revealed a high potential ecological risk in counties and a moderate risk in cities. Cluster analysis suggested that groundwater microplastics were a confluence of hydraulic interactions between surface and subsurface waters within the Danxia region. This investigation elucidates the microplastic contamination profile, origins, migratory patterns, and associated risks in Danxia's urban rivers, thereby furnishing scientific underpinning for health and ecological preservation strategies within urbanized Danxia landscapes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)