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The yield of winter wheat in Shandong Province is of great significance for ensuring regional and national food security. To reduce the risk of production loss, the WOFOST model was used to simulate the winter wheat growth to obtain the quantitative and dynamic information. Based on the observational data, a moisture control experiment and the trial and error method, the applicability and drought simulation of the WOFOST model were evaluated for winter wheat growth. For the simulation of the seedling period, flowering period, and maturity period of winter wheat in Shandong Province, the R2 were 0.95, 0.69, and 0.68 respectively. The D-index were 0.99, 0.89, and 0.86 respectively. The mean absolute error (mAE) were 1.3, 4.3, and 4.1 respectively. And the nRMSE were 0.65%, 4.3%, and 3.2%, respectively. For the yield simulation, the R2, D-index, mean relative error (mRE), and nRMSE were 0.48, 0.82, 10.5% and 12.8%, respectively. For the yield simulation under drought stress, the R2, D-index, mRE, and nRMSE were 0.77, 0.93, 7.1%, and 7.4%, respectively. An evaluation index system was built through four different degrees of drought treatment between the jointing period and the flowering period. With the aggravation of drought, the growth indicators about the total above ground production (TAGP), maximum leaf area index (MAXLAI), total dry weight of leaves (TWLV), and total dry weight of stems (TWST) decreasing by 13.6–41.0%, 37.8–56.5%, 19.4–42.1%, and 20.3–51.2%, respectively. The results showed that this model could adequately simulate the formation process of yield under both normal and drought conditions.