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Your search keyword '"nad metabolic pathway"' showing total 2 results
Start Over "nad metabolic pathway" Publisher elsevier
2 results on '"nad metabolic pathway"'

1. Progress and Recent Trends in Microbial Fuel Cells

Author

Patit Paban Kundu, Kingshuk Dutta, Patit Paban Kundu, and Kingshuk Dutta

Subjects
Microbial fuel cells
Abstract

Progress and Recent Trends in Microbial Fuel Cells provides an in-depth analysis of the fundamentals, working principles, applications and advancements (including commercialization aspects) made in the field of Microbial Fuel Cells research, with critical analyses and opinions from experts around the world. Microbial Fuel cell, as a potential alternative energy harnessing device, has been progressing steadily towards fruitful commercialization. Involvements of electrolyte membranes and catalysts have been two of the most critical factors toward achieving this progress. Added applications of MFCs in areas of bio-hydrogen production and wastewater treatment have made this technology extremely attractive and important.. - Reviews and compares MFCs with other alternative energy harnessing devices, particularly in comparison to other fuel cells - Analyses developments of electrolyte membranes, electrodes, catalysts and biocatalysts as critical components of MFCs, responsible for their present and future progress - Includes commercial aspects of MFCs in terms of (i) generation of electricity, (ii) microbial electrolysis cell, (iii) microbial desalination cell, and (iv) wastewater and sludge treatment

Published
2018

2. "Identification of alkaloid compounds as potent inhibitors of Mycobacterium tuberculosis NadD using computational strategies".

Author

Verma AK, Dubey S, and Srivastava SK

Subjects
NAD, Molecular Dynamics Simulation, Molecular Docking Simulation, Mycobacterium tuberculosis, Antineoplastic Agents, Alkaloids pharmacology
Abstract

Mycobacterium tuberculosis is leading cause of death worldwide. NAD participates in a host of redox reactions in energy landscape of organisms. Several studies implicate surrogate energy pathways involving NAD pools as important in survival of active as well as dormant mycobacteria. One of the NAD metabolic pathway enzyme, nicotinate mononucleotide adenylyltransferase (NadD) is indispensable in mycobacterial NAD metabolism and is perceived as an attractive drug target in pathogen. In this study, we have employed in silico screening, simulation and MM-PBSA strategies to identify potentially important alkaloid compounds against mycobacterial NadD for structure-based inhibitor development. We have performed an exhaustive structure-based virtual screening of an alkaloid library, ADMET, DFT profiling followed by Molecular Dynamics (MD) simulation, and Molecular Mechanics-Poisson Boltzmann Surface Area (MM-PBSA) calculation to identify 10 compounds which exhibit favourable drug like properties and interactions. Interaction energies of these 10 alkaloid molecules range between -190 kJ/mol and -250 kJ/mol. These compounds could be promising starting point in the development of selective inhibitors against Mycobacterium tuberculosis., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Published
2023
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