11 results on '"van Delft, Joost"'
Search Results
2. List of Contributors
- Author
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Alloul-Ramdhani, Marjam, primary, Auerbach, Scott S., additional, Benedetti, Giulia, additional, Besselink, Harrie, additional, Boorsma, André, additional, Brouwer, Bram, additional, Chaves, Ines, additional, Coonen, Maarten, additional, Corsini, Emanuela, additional, Danen, Erik H.J., additional, de Graauw, Marjo, additional, Destici, Eugin, additional, Driessen, Marja, additional, Fostel, Jennifer, additional, Ghalbzouri, Abdoelwaheb El, additional, Hermsen, Sanne A.B., additional, Hettne, Kristina M., additional, Jansen, Wouter T.M., additional, Jomaa, Barae, additional, Kleinjans, Jos, additional, Kors, Jan A., additional, Kroese, Dinant, additional, Luebke, Robert, additional, Mathijs, Karen, additional, Nijman, Romana, additional, Paules, Richard S., additional, Pennings, Jeroen, additional, Piersma, Aldert H., additional, Polman, Jan, additional, Price, Leo S., additional, Pronk, Tessa, additional, Ramaiahgari, Sreenivasa, additional, Roggen, Erwin L., additional, Schmeits, Peter, additional, Schretlen, Jan Hendrik R.H.M., additional, Shao, Jia, additional, Stierum, Rob H., additional, Suter-Dick, Laura, additional, Szalowska, Ewa, additional, Tensen, Cornelis P., additional, Tonk, Elisa C.M., additional, Verheyen, Geert R., additional, Volger, Oscar L., additional, de Wit, Annelieke S., additional, van der Burg, Bart, additional, van Delft, Joost, additional, van Goethem, Freddy, additional, van Loveren, Henk, additional, van Someren, Eugene, additional, van de Ven, Leo, additional, van de Water, Bob, additional, van der Horst, Gijsbertus T.J., additional, and von Stechow, Louise, additional
- Published
- 2014
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3. Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells
- Author
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Linschooten, Joost O, Van Schooten, Frederik J, Baumgartner, Adi, Cemeli, Eduardo, Van Delft, Joost, Anderson, Diana, and Godschalk, Roger WL
- Subjects
RZ - Published
- 2009
4. Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices.
- Author
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Jetten MJ, Claessen SM, Dejong CH, Lahoz A, Castell JV, van Delft JH, and Kleinjans JC
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- Acetaminophen toxicity, Aflatoxin B1 toxicity, Benzo(a)pyrene toxicity, Cell Survival drug effects, Comet Assay, Cytochrome P-450 Enzyme System genetics, DNA Damage, Fluorenes toxicity, Gene Expression, Glutathione Transferase genetics, Humans, L-Lactate Dehydrogenase metabolism, Liver metabolism, NAD(P)H Dehydrogenase (Quinone) genetics, Liver drug effects, Xenobiotics toxicity
- Abstract
Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity responses by assessing dose-response relationships for several prototypical hepatotoxicants. Baseline levels of cytochrome-P450 (CYP) GE/EA were measured in precision-cut human liver slices. Slices (n=4-5/compound) were exposed to a dose-range of acetaminophen, aflatoxin B1, benzo(α) pyrene or 2-nitrofluorene. Interindividual variation in induced genotoxicity (COMET-assay and CDKN1A/p21 GE) and cytotoxicity (lactate dehydrogenase-leakage), combined with NQO1- and GSTM1-induced GE-responses for oxidative stress and GE-responses of several CYPs was evaluated. The benchmark dose-approach was applied as a tool to model exposure responses on an individual level. Variation in baseline CYP levels, both GE and EA, can explain variation in compound exposure-responses on an individual level. Network analyses enable the definition of key parameters influencing interindividual variation after compound exposure. For 2-nitrofluorene, this analysis suggests involvement of CYP1B1 in the metabolism of this compound, which represents a novel finding. In this study, GSTM1 which is known to be highly polymorphic within the human population, but so far could not be linked to toxicity in acetaminophen-poisoned patients, is suggested to cause interindividual variability in acetaminophen-metabolism, dependent on the individual's gene expression-responses of CYP-enzymes. This study demonstrates that using interindividual variation within network modelling provides a source for the definition of essential and even new parameters involved in compound-related metabolism. This information might enable ways to make more quantitative estimates of human risks., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2014
- Full Text
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5. Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis.
- Author
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Kienhuis AS, Vitins AP, Pennings JL, Pronk TE, Speksnijder EN, Roodbergen M, van Delft JH, Luijten M, and van der Ven LT
- Subjects
- Alanine Transaminase blood, Animals, Aspartate Aminotransferases blood, Bile Acids and Salts blood, Bilirubin blood, Cholestasis blood, Cholestasis genetics, Cholesterol blood, Gene Expression drug effects, Gene Expression Profiling methods, Hep G2 Cells, Histocytochemistry, Humans, Male, Mice, Mice, Inbred C57BL, Phenotype, Specific Pathogen-Free Organisms, Toxicogenetics, Cholestasis chemically induced, Cyclosporine toxicity
- Abstract
In vitro models for hepatotoxicity testing are a necessity for advancement of toxicological research. Assessing the in vitro response requires in vivo validated gene sets reflective of the hepatotoxic phenotype. Cholestasis, the impairment of bile flow, is induced in C57BL/6J mice treated with cyclosporine A (CsA) to identify phenotype reflective gene sets. CsA treatment through oral gavage for 25 days induced cholestasis, as confirmed by histopathology and serum chemistry. Over 1, 4, and 11 days of CsA exposure gradual increases in serum markers were correlated to gene expression. This phenotype-directed analysis identified gene sets specific to the onset and progression of cholestasis, such as PPAR related processes and drug metabolism, by circumventing other effects of CsA, such as immunosuppression, found in dose*time group analysis. In vivo gene sets are enriched in publicly available data sets of CsA-treated HepaRG and primary mouse hepatocytes. However, genes identified within these gene sets did not overlap between in vivo and in vitro. In vitro regulated genes represent the initial response to cholestasis, whereas in vivo genes represent the later adaptive response. We conclude that the applicability of in vitro models for hepatotoxicity testing fully depends on a solid in vivo phenotype anchored analysis., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
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6. A lyophilized red grape pomace containing proanthocyanidin-rich dietary fiber induces genetic and metabolic alterations in colon mucosa of female C57BL/6J mice.
- Author
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Lizarraga D, Vinardell MP, Noé V, van Delft JH, Alcarraz-Vizán G, van Breda SG, Staal Y, Günther UL, Carrigan JB, Reed MA, Ciudad CJ, Torres JL, and Cascante M
- Subjects
- Animals, Colon metabolism, Diet, Female, Gene Expression Profiling, Gene Expression Regulation drug effects, Intestinal Mucosa metabolism, Mice, Mice, Inbred C57BL, Oligonucleotide Array Sequence Analysis, Random Allocation, Colon drug effects, Dietary Fiber pharmacology, Intestinal Mucosa drug effects, Proanthocyanidins chemistry, Proanthocyanidins pharmacology, Vitis chemistry
- Abstract
Diet plays a decisive role in promoting or preventing colon cancer. However, the specific effects of some nutrients remain unclear. The capacity of fruit and vegetables to prevent cancer has been associated with their fiber and antioxidant composition. We investigated whether consumption of a lyophilized red grape pomace containing proanthocyanidin-rich dietary fiber (grape antioxidant dietary fiber, GADF) by female C57BL/6J mice would affect the serum metabolic profile or colon mucosa gene expression using NMR techniques and DNA microarray, respectively. The mice were randomly assigned to 2 groups that for 2 wk consumed a standard rodent diet and were gavaged with 100 mg/kg body weight GADF suspended in water or an equivalent volume of plain tap water (10 mL/kg body weight). The amount of fiber supplemented was calculated to equal the current recommended daily levels of fiber consumption for humans. The inclusion of dietary GADF induced alterations in the expression of tumor suppressor genes and proto-oncogenes as well as the modulation of genes from pathways, including lipid biosynthesis, energy metabolism, cell cycle, and apoptosis. Overexpression of enzymes pertaining to the xenobiotic detoxifying system and endogenous antioxidant cell defenses was also observed. In summary, the genetic and metabolic profiles induced by GADF were consistent with the preventive effects of fiber and polyphenols. On the basis of these observations, we propose that GADF may contribute to reducing the risk of colon cancer.
- Published
- 2011
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7. The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.
- Author
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Vinken M, Doktorova T, Ellinger-Ziegelbauer H, Ahr HJ, Lock E, Carmichael P, Roggen E, van Delft J, Kleinjans J, Castell J, Bort R, Donato T, Ryan M, Corvi R, Keun H, Ebbels T, Athersuch T, Sansone SA, Rocca-Serra P, Stierum R, Jennings P, Pfaller W, Gmuender H, Vanhaecke T, and Rogiers V
- Subjects
- Animal Testing Alternatives, European Union, Gene Expression Profiling, Hazardous Substances, International Cooperation, Toxicogenetics trends, Carcinogenicity Tests methods, Genomics methods
- Abstract
Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing the carcinogenic potential of chemical compounds in a pan-European context. This paper provides an in-depth analysis of the complexity of choosing suitable reference compounds used for creating and fine-tuning the in vitro carcinogenicity assays. First, a number of solid criteria for the selection of the model compounds are defined. Secondly, the strategy followed, including resources consulted, is described and the selected compounds are briefly illustrated. Finally, limitations and problems encountered during the selection procedure are discussed. Since selecting an appropriate set of chemicals is a frequent impediment in the early stages of similar research projects, the information provided in this paper might be extremely valuable.
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- 2008
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8. SFTG international collaborative study on in vitro micronucleus test II. Using human lymphocytes.
- Author
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Clare MG, Lorenzon G, Akhurst LC, Marzin D, van Delft J, Montero R, Botta A, Bertens A, Cinelli S, Thybaud V, and Lorge E
- Subjects
- Adult, Aneugens toxicity, Bleomycin toxicity, Clofibrate toxicity, Colchicine toxicity, Cytarabine toxicity, Diethylstilbestrol toxicity, Female, Fluorouracil toxicity, Humans, In Vitro Techniques, International Cooperation, Male, Mannitol toxicity, Thiabendazole toxicity, Urethane toxicity, Lymphocytes drug effects, Micronucleus Tests methods, Mutagens toxicity
- Abstract
This study on the in vitro micronucleus assay, comprising 11 laboratories using human lymphocytes, was coordinated by an organizing committee supported by the SFTG (the French branch of the European Environmental Mutagen Society). Nine coded substances were assessed for their ability to induce micronuclei in human lymphocytes in vitro, mitomycin C being used as a positive control. Cultures were exposed to the test substances for a short (early or late) time or for a long time, followed by a short or long recovery period, in the presence of cytochalasin B. Each chemical was evaluated, generally in two laboratories, using three treatment schedules at least twice. The data were assessed for acceptability, and then classified as negative, positive or equivocal. Two of seven genotoxic compounds, namely colchicine and bleomycin, clearly induced micronuclei. Reproducible results were difficult to obtain for some substances, which tended to be those acting at specific stages of the cell cycle. Cytosine arabinoside, diethylstilboestrol and 5-fluorouracil were classified as equivocal. Urethane and thiabendazole were classified as negative. The two presumed non-genotoxic compounds, mannitol and clofibrate, did not induce micronuclei. Repeat testing, exposing cells at both an early and late time after mitogenic stimulation, was needed to detect substances classified as equivocal. These results show the importance of achieving sufficient inhibition of nuclear division to avoid the possibility of missing an effect. The evaluation of micronuclei in mononucleated as well as binucleated cells was particularly useful to detect aneugens. There were no false positive results using lymphocytes, indicating a high specificity. It is concluded that the clastogenic or aneugenic potential in vitro of the substances tested was correctly identified in this study, but that refining the protocol to take into account factors such as the stages of the cell cycle exposed to the compound, or the duration of recovery would be likely to improve the sensitivity of detection using lymphocytes.
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- 2006
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9. Toxicogenomics in genetic toxicology and hazard determination: introduction and overview.
- Author
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Sarrif A, van Delft JH, van Schooten FJ, Gant TW, Elliott BM, van Ravenzwaay B, van Steeg H, and Vrijhof H
- Subjects
- Animals, Gene Expression Profiling, Humans, Oligonucleotide Array Sequence Analysis, Toxicogenetics trends
- Published
- 2005
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10. Toxicogenomics in genetic toxicology and hazard determination--concluding remarks.
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Sarrif A, van Delft JH, Gant TW, Kleinjans JC, and van Vliet E
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- Animals, Gene Expression Profiling standards, Humans, Oligonucleotide Array Sequence Analysis standards, Reproducibility of Results, Research Design, Toxicogenetics standards, Genomics standards, Toxicogenetics trends
- Published
- 2005
- Full Text
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11. Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice.
- Author
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van Breda SG, van Agen E, van Sanden S, Burzykowski T, Kienhuis AS, Kleinjans JC, and van Delft JH
- Subjects
- Animals, Body Weight, Diet, Enzymes genetics, Female, Mice, Mice, Inbred C57BL, Models, Animal, Proteins genetics, Anticarcinogenic Agents metabolism, Colon physiology, Gene Expression Regulation, Intestinal Mucosa physiology, Oligonucleotide Array Sequence Analysis, Vegetables
- Abstract
There is abundant epidemiological evidence that vegetable consumption decreases colorectal cancer (CRC) risk. However, the molecular targets in the genome are mostly unknown. The present study investigated the effects of vegetable consumption on gene expression in the colon mucosa of female C57Bl/6 mice using cDNA microarray technology. Mice were fed one of 8 diets: a control diet containing no vegetables (diet 1); a diet containing 100 g/kg (diet 2, 10% dose), 200 g/kg (diet 3, 20% dose), or 400 g/kg (diet 4, 40% dose) of a vegetable mixture; or a diet containing 70 g/kg of cauliflower (diet 5, 7% dose), 73 g/kg of carrots (diet 6, 7.3% dose), 226 g/kg of peas (diet 7, 22.6% dose); or 31 g/kg of onions (diet 8, 3.1% dose). The vegetable mixture used in diets 2 to 4 consisted of the 4 individual vegetables used in diets 5 to 8: cauliflower (30% wet wt), carrots (30% wet wt), peas (30% wet wt), and onions (10% wet wt). To assess gene expression changes, colonic mucosal cells were collected after the mice were killed. Total RNA was isolated and microarray technology was used to measure the expression levels of 602 genes simultaneously. For 39 genes, significant dose-dependent effects were found, although in general the relations were not linear. For 15 genes, the altered expression could indeed explain reduced cancer risk at various stages of CRC development. Eleven genes were modulated by the vegetable mixture as well as by one or more of the individual vegetables. For 7 of the genes, the modulation by the mixture was due to the effect of a particular vegetable. These genes are of particular interest because they were consistently affected and could be involved in the prevention of CRC by vegetable consumption.
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- 2005
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