1. Zinc sensing and regulation in yeast model systems.
- Author
-
Wilson S and Bird AJ
- Subjects
- Homeostasis, Protein Domains, Saccharomyces cerevisiae metabolism, Schizosaccharomyces metabolism, Transcription, Genetic, Transcriptional Activation, Zinc Fingers, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins metabolism, Schizosaccharomyces pombe Proteins metabolism, Transcription Factors metabolism, Zinc chemistry
- Abstract
The Zap1 transcription factor of Saccharomyces cerevisiae and the Loz1 transcription factor of Schizosaccharomyces pombe both play a central role in zinc homeostasis by controlling the expression of genes necessary for zinc metabolism. Zap1 activates gene expression when cells are limited for zinc, while Loz1 is required for gene repression when zinc is in excess. In this review we highlight what is known about the underlying mechanisms by which these factors are regulated by zinc, and how transcriptional activation and repression in eukaryotic cells can be finely tuned according to intracellular zinc availability., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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