1. Antibacterial oleanane-type triterpenoids from pericarps of Akebia trifoliata.
- Author
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Wang J, Ren H, Xu QL, Zhou ZY, Wu P, Wei XY, Cao Y, Chen XX, and Tan JW
- Subjects
- Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Fruit chemistry, Fruit metabolism, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molecular Conformation, Oleanolic Acid isolation & purification, Oleanolic Acid pharmacology, Plant Extracts pharmacology, Streptophyta metabolism, Anti-Bacterial Agents chemistry, Oleanolic Acid chemistry, Plant Extracts chemistry, Streptophyta chemistry
- Abstract
Three new oleanane triterpenoids, 2α,3β,29-trihydroxyolean-12-en-28-oic acid (1), 2α,3β-dihydroxy-23-oxo-olean-12-en-28-oic acid (2) and 2α,3β,21β,22α-tetrahydroxyolean-12-en-28,29-dioic acid (3), and ten known ones, maslinic acid (4), arjunolic acid (5), oleanolic acid (6), 3-epi-oleanolic acid (7), stachlic acid A (8), serratagenic acid (9), gypsogenic acid (10), 2α,3β-dihydroxyol-ean-13(18)-en-28-oic acid (11), mesembryanthemoidigenic acid (12) and 12α-hydroxy-δ-lactone (13), were isolated from the pericarps of Akebia trifoliata, a new valued fruit crop in China. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 8, 10, 11 and 13 were isolated for the first time from the genus Akebia. All the compounds were tested for their antimicrobial activity against five bacterial strains. Compounds 4, 6 and 11 showed significant antibacterial activity toward all the assayed microorganisms with MIC values ranging from 0.9 to 15.6μg/mL, which were close or even more potent than the reference compound Kanamycin (MIC values ranging from 1.9 to 3.9μg/mL)., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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