1. Drug-free contact lens based on quaternized chitosan and tannic acid for bacterial keratitis therapy and corneal repair.
- Author
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Jiao Z, Huo Q, Lin X, Chu X, Deng Z, Guo H, Peng Y, Lu S, Zhou X, Wang X, and Wang B
- Subjects
- Animals, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Escherichia coli, Hydrogels chemistry, Tannins pharmacology, Tannins therapeutic use, Chitosan chemistry, Contact Lenses, Keratitis drug therapy
- Abstract
Bacterial keratitis (BK) and related inflammatory diseases causes irreversible damage to the corneal tissue. In this study, a novel polyacrylamide semi-interpenetrating network hydrogel including quaternized chitosan and tannic acid (PAM-QCS-TA) were used to construct a novel antibacterial and antioxidant contact lens. The obtained hydrogels showed high water content (>85%), swelling resistance, light transmittance (>90%) and adjustable mechanical property. Both quantitative and qualitative antibacterial experiments against Staphylococcus aureus and Escherichia coli (E. coli) indicated excellent sterilization function especially against E. coli (almost 100%). Due to the presence of tannin acid, it showed obvious antioxidant properties, which relieved oxidative stress and protect cells from reactive oxygen species-induced cytotoxicity. Animal experiments also indicated the shortened treatment time of BK (only 3 days) as well as the protection of eye tissue structure. Therefore, such drug-free antibacterial and antioxidant contact lens avoiding the development of drug resistance is a potential candidate in ocular infectious and inflammatory diseases treatment., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
- Published
- 2022
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