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Background and Purpose: Radiodermatitis is a well-known toxicity of radiotherapy and barrier film has been shown to reduce the severity of radiodermatitis. We have validated prior findings in a Danish cohort, using a similar barrier film and patient reported outcomes., Materials and Methods: 101 Danish breast cancer patients were included at three radiotherapy centres. Based on randomization either the lateral or medial part of their chest was covered by Mepitel film; making the patients their own control. The primary endpoint was patient reported symptoms and experience. A secondary endpoint was radiotherapy staff evaluation of dermatitis., Results: Within the skin area covered by film, the patients reported a statistical significant lower level of pain ( p < .001 ), itching ( p = 0.005 ), burning sensation ( p = 0.005 ) as well as edema (p = 0.017) and reduced sensitivity ( p < .001 ). Most patients (76%) would have preferred film on the entire treatment area ( p < 0.001 ) and Mepitel Film as a standard treatment option (84%) ( p < 0.001 ). Patients treated after mastectomy had a significantly lower severity of radiation-induced dermatitis with film at the end of RT compared to standard care ( p = 0.005 ). However, in the blinded staff evaluation, no significant differences were found at follow-up., Conclusions: Patients reported reduced symptoms from the skin with Mepitel Film and the majority would have preferred film as a standard offer to cover their entire treatment area. Especially women treated after mastectomy had a significantly lower level of radiodermatitis and preferred the film over standard care., (© 2018 The Authors.)