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In this work, we develop a mathematical model to study the effect of drug on the development of cancer including the quiescent compartment. The model is governed by a system of delay differential equations where the delay represents the time that the cancer cell take to proliferate. Our analytical study of the stability shows that by considering the time delay as a parameter of bifurcation, it is possible to have stability switch and oscillations through a Hopf bifurcation. Moreover, by introducing the drug intervention term, the critical delay value increases. This indicates that the system can tolerate a longer delay before oscillations start. In the end, we present some numerical simulations illustrating our theoretical results. [ABSTRACT FROM AUTHOR]

Abstract: In the machining process, unstable self-excited vibrations known as regenerative chatter can occur, causing excessive tool wear or failure, and a poor surface finish on the machined workpiece, hence the relevant measures must be taken to predict and avoid this phenomenon of instability. In this paper, we propose a weakly nonlinear model with square and cubic terms in both structural stiffness and regenerative terms, to represent self-excited vibrations in machining. It is proved that Hopf bifurcation exists when bifurcation parameter equals a critical value, a formula for determining the direction of the Hopf bifurcation and the stability of bifurcating periodic solutions are given by using the normal form method and center manifold theorem. Numerical simulations show excellent agreement with the theoretical results. [Copyright &y& Elsevier]

Abstract: In this paper, we study the influence of time delays on the dynamics of the classical Gompertz model. We consider the models with one discrete delay introduced in two different ways and the model with two delays which generalise those with one delay. We study asymptotic behaviour and bifurcations with respect to the ratio of delays . Our results show that in such model with two delays there is only one stability switch and for a threshold value of bifurcation parameter, Hopf bifurcation (HB) occurs. However, the type of HB, and therefore its stability (i.e. stability of periodic orbits arising due to it), strongly depends on the magnitude of . The function describing stability of HB is periodic with respect to . Within one period of length 4 five changes of HB stability are observed. We also introduce the second model with two delays which has a better biological interpretation than the first one. In that model several stability switches can occur, depending on the model parameters. We illustrate analytical results on the example of tumour growth model with parameters estimated on the basis of experimental data. [Copyright &y& Elsevier]

In this paper, we set up the dynamical models for an industrial system by means of ordinary or delay differential equations. By the qualitative analyses to the equilibrium points of the differential equations, we indicate how the parameters influence the equilibrium states of the system. [Copyright &y& Elsevier]