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Your search keyword '"Cao, Xiaoyu"' showing total 160 results
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160 results on '"Cao, Xiaoyu"'

39. Rosai-Dorfman Disease in the Skull Base: A Case Series Study.

Author

Cao, Xiaoyu, Yao, Bohan, Ma, Junpeng, Li, Da, Wang, Liang, Zhang, Junting, and Wu, Zhen

Subjects
*SKULL base, *NON-langerhans-cell histiocytosis, *CENTRAL nervous system
Abstract

Rosai-Dorfman disease (RDD) is a rare, idiopathic, and non-neoplastic histio-proliferative disease that is uncommon in the central nervous system. Hence, reports of management of RDD in the skull base are scarce and only a few studies on skull base RDD are available. The objective of this study was to analyze the diagnosis, treatment, and prognosis of RDD in the skull base and explore an appropriate treatment strategy thereof. Nine patients with clinical characteristics and follow-up data from our department between 2017 and 2022 were included in this study. From this information, the clinical profiles, imaging, treatment, and prognosis data were collected. There were 6 male and 3 female patients with skull base RDD. These patients ranged in age from 13 to 61 years, with a median age of 41 years. The locations included 1 anterior skull base orbital apex, 1 parasellar region, 2 sellar regions, 1 petroclivus, and 4 foramen magnum regions. Six patients underwent total resection and 3 underwent subtotal resection. Patient follow-up lasted 11–65 months, with a median duration of 24 months. One patient died, 2 experienced recurrence, and the other patients' lesions were stable. The symptoms worsened and new complications occurred in 5 patients. Skull base RDDs are intractable diseases with a high rate of complications. Some patients are at risk of recurrence and death. Surgery may be the basic treatment for this disease, and combined therapy including targeted therapy or radiation therapy may also be a valuable therapeutic strategy. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Influence of coarse fly ash on the performance of foam concrete and its application in high-speed railway roadbeds

Author

Shea, Wei, Du, Yi, Zhao, Guotang, Feng, Pan, Zhang, Yunsheng, and Cao, Xiaoyu

Subjects
Concretes -- Analysis -- Chemical properties -- Mechanical properties, Water transfer -- Analysis, CAT scans -- Usage, Fly ash -- Analysis, Business, Construction and materials industries
Abstract

ABSTRACT In this paper, the potential of using foam concrete as a lightweight filling material for high-speed railway roadbeds was studied. The influence of coarse fly ash on the workability, [...]

Published
2018
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42. Numerical study on the effect of pore shapes on the thermal behaviors of cellular concrete

Author

She, Wei, Zhao, Guotang, Cai, Degou, Jiang, Jinyang, and Cao, Xiaoyu

Subjects
Concretes -- Thermal properties -- Mechanical properties -- Analysis, Thermal conductivity -- Analysis, Finite element method -- Analysis, Heat transfer -- Analysis, Business, Construction and materials industries
Abstract

ABSTRACT This paper proposes a numerical method to study the effect of pore shapes on the effective thermal conductivity (ETC) of cellular concrete by a two-dimensional model. Cellular concrete can [...]

Published
2018
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48. Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics.

Author

Huang, JingYi, Cao, XiaoYu, Wu, WenFeng, Han, Liang, and Wang, FengYun

Subjects
*CENTELLA asiatica, *AMINO acid synthesis, *METABOLOMICS, *AMINO acid metabolism, *REACTIVE oxygen species
Abstract

Nano-particles demonstrating excellent anticancer properties have gradually found application in cancer therapy. However, their widespread use is impeded by their potential toxicity, high cost, and the complexity of the preparation process. In this study, we achieved exosome-like Centella asiatica -derived nanovesicles (ADNVs) through a straightforward juicing and high-speed centrifugation process. We employed transmission electron microscopy and nanoparticle flow cytometry to characterize the morphology, diameter, and stability of the ADNVs. We evaluated the in vitro anticancer effects of ADNVs using Cell Counting Kit-8 and apoptosis assays. Through sequencing and bicinchoninic acid protein analysis, we discovered the abundant presence of proteins and microRNAs in ADNVs. These microRNAs can target various diseases such as cancer and infection. Furthermore, we demonstrated the effective internalization of ADNVs by HepG2 cells, resulting in an increase in reactive oxygen species levels, mitochondrial damage, cell cycle arrest at the G1 phase, and apoptosis. Finally, we analyzed changes in cellular metabolites post-treatment using cell metabolomics techniques. Our findings indicated that ADNVs primarily influence metabolic pathways such as amino acid metabolism and lipid biosynthesis, which are closely associated with HepG2 treatment. Our results demonstrate the potential utility of ADNVs as anticancer agents. [Display omitted] • ADNVs contain a large number of mirnas that can target cancer. • The growth of reactive oxygen species in HepG2 cells was enhanced by ADNVs. • ADNVs may affect the proliferation of HepG2 cells through related metabolic pathways such as amino acid and lipid synthesis. • ADNVs may represent a new application of plant-derived nanomedicine in cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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