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Abstract: Background: The aim of the present study was to appraise the comparative ability of different ACEF models incorporating glomerular filtration rate or creatinine clearance estimated by the Modification of Diet in Renal Disease [ACEFMDRD] or Cokcroft-Gault [ACEFCG] equations, respectively, over the original ACEF score (ACEFSrCr) in patients undergoing percutaneous coronary intervention (PCI). Methods: A total of 537 patients were analyzed by different measures of discrimination, calibration and net reclassification improvement (NRI). Results: A significant gradient in all-cause mortality was consistently seen with all the models at 30days, 1year and 5years. The comparison of the three models showed that the best balance in terms of discrimination and calibration for all-cause mortality was offered by the ACEFCG at 30days, the ACEFMDRD at 1year and similarly by the ACEFCG and ACEFMDRD at 5years. At 30days, the NRI was +32.9% for ACEFMDRD over ACEFSrCr and +16% for ACEFCG over ACEFSrCr. At 1year, the NRI was 13.8% for ACEFMDRD over ACEFSrCr and −7.8% for ACEFCG over ACEFSrCr. At 5years, the NRI was +7.7% for both the ACEFMDRD and the ACEFCG over the ACEFSrCr. Conclusions: In patients undergoing PCI, the ACEF score is associated with satisfactory early-, mid- and long-term discrimination regardless of the definition of renal function. However, incorporating glomerular filtration rate or creatinine clearance by the MDRD or CG formulas in the ACEF score yields superior calibration compared with the original SrCr-based equation, with the ACEFMDRD displaying superior reclassification ability over the ACEFCG and ACEFSrCr at 30days and 1year. [Copyright &y& Elsevier]