1. Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis
- Author
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Franco, Marcelo De, Colombo, Francesca, Galvan, Antonella, Cecco, Loris De, Spada, Elena, Milani, Silvano, Ibanez, Olga M., and Dragani, Tommaso A.
- Subjects
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LUNG diseases , *LABORATORY mice , *CELL lines , *INFLAMMATION , *CARCINOGENESIS , *URETHANE , *GENE expression - Abstract
Abstract: AIRmax and AIRmin mouse lines show a differential lung inflammatory response and differential lung tumor susceptibility after urethane treatment. The transcript profile of ∼24,000 known genes was analyzed in normal lung tissue of untreated and urethane-treated AIRmax and AIRmin mice. In lungs of untreated mice, inflammation-associated genes involved in pathways such as “leukocyte transendothelial migration”, “cell adhesion” and “tight junctions” were differentially expressed. Moreover, gene expression levels differed significantly in urethane-treated mice; in AIRmin mice, modulation of expression of genes involved in pathways associated with inflammatory response paralleled the previously observed persistent infiltration of inflammatory cells in the lung of these mice. [Copyright &y& Elsevier]
- Published
- 2010
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