1. Antioxidant and anti-aging activities of the polysaccharide TLH-3 from Tricholoma lobayense.
- Author
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Ding, Qiuying, Yang, Dan, Zhang, Wenna, Lu, Yongming, Zhang, Mingzhu, Wang, Liming, Li, Xuehui, Zhou, Liyuan, Wu, Qingxi, Pan, Wenjuan, and Chen, Yan
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ANTIOXIDANTS , *AGING prevention , *POLYSACCHARIDES , *THALLIUM , *TRICHOLOMA , *EDIBLE fungi , *REACTIVE oxygen species - Abstract
Polysaccharides from edible fungi usually exhibit many bioactivities. Our previous studies found that polysaccharide TLH-3 extracted from Tricholoma lobayense possessed noticeable antioxidant activity. To further explore its biological activities, the antioxidant and anti-aging activities of TLH-3 were evaluated in vitro and in vivo . The results of antioxidant activity in vitro showed that TLH-3 could enhance the cell viability, reduce the production of reactive oxygen species (ROS) and inhibit oxidative damage induced by tert -butylhydroperoxide ( t -BHP) in human embryonic lung fibroblasts (HELF) cells. The anti-aging capability was measured in d -galactose ( d -gal)-induced aged mice model, and the experimental data showed that TLH-3 significantly inhibited the formation of malondialdehyde (MDA) and raised the activities of superoxide dismutase (SOD) and catalase (CAT) in mice liver and serum ( p < 0.05). This study suggested that TLH-3 possessed apparent antioxidant and anti-aging activities and could be exploited as a potent dietary supplement to attenuate aging and prevent age-related diseases in humans. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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