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1. Catalyst-free synthesis of alkyl 4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate derivatives on water.

Author

Yan, Hao, Ma, Ying, Sun, Yuanjun, Ma, Chao, Wang, Yuling, Ren, Xiaoyu, and Huang, Guosheng

Subjects
*CHEMICAL synthesis, *CARBOXYLATES, *CARBOXYLATE derivatives, *CHEMICAL structure, *PHASE equilibrium, *BIOACTIVE compounds, *SUSTAINABLE chemistry
Abstract

Abstract: An environmentally friendly and effective method to construct 4H-pyrido[1,2-a]pyrimidin-4-one, which are ubiquitous structural units in a number of biologically active compounds has been developed. In this process, the reaction using water as the solvent in absence of catalyst under the mild conditions makes transformations very green, practical, and attractive. [Copyright &y& Elsevier]

Published
2014
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