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• A framework was provided for analyzing change causes of runoff and sediment load. • Runoff change attribution analysis was incorporated in quantifying sediment change. • Dam construction obviously disturbed the evolution characteristics of sediment load. Under the background of climate variability and anthropogenic stresses, changes of the runoff and sediment processes have drawn increasing concerns during the past decades. Analyzing the evolution characteristics and causes of runoff and sediment load is critical for the sustainable development of water resource and terrestrial ecosystems of river basins. This study presents an integrated approach for analyzing the evolution characteristics of the annual runoff and sediment load, including the trend, periodicity, change point and their correlations in the Wujiang River basin (WRB) –a typical mountainous river system in southwest China, based on the observed data during the period 1970–2016. On this basis, the contributions of climate variability and human activities on runoff change were first distinguished by using a widely applied Budyko-based hydrological sensitivity method, and then the quantified result was further applied in the attribution analysis of river sediment load change. Research results revealed that the change patterns of runoff and sediment processes, such as the trend, periodicity and potential change point, as well as the relationships of precipitation-runoff and runoff-sediment load are quite different in the WRB. Quantitative assessment revealed that climate variability contributes to 71.5%–85.6% changes of mean annual runoff in 1985–1994, 1995–2004 and 2005–2016 with reference to the baseline period of 1970–1984. In contrary, human activities dominate the reduction of sediment load in the river, and the contribution rate ranged in 67.2%–107.5%. Variations of annual runoff in the WRB was the direct result of climate variability, while land use change played a secondary role. The construction of cascade hydropower reservoirs, particularly in the upper and middle reaches of the Wujiang River is fundamentally responsible for the significant decreasing and the weakened periodicity of sediment load as well as the changed runoff-sediment load correlation at Wulong station in recent years. However, this influence was not big enough to modify the regime of annual runoff. [ABSTRACT FROM AUTHOR]