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The 4.2 ka event was a period of global drought and climate cooling linked to the widespread disruption of Neolithic culture. However, the detailed climatic changes during this period are not completely understood. In this paper, we report a high-resolution pollen record for the Dayanghu wetland in the Zhejiang region of southeastern China, which we use to infer mean annual precipitation (MAP) fluctuations during the period spanning 4600–4000 calendar years before present (cal. yr BP). There was a long-term trend of decreasing MAP during this interval, consistent with weakening of the East Asian Summer Monsoon since the mid-Holocene. This trend was punctuated by episodes of relatively high MAP at 4350–4320, ca. 4260, and 4220–4200 cal. yr BP, and extreme droughts at 4200 and 4150 cal. yr BP. We propose that solar activity promoted El Niño events and contributed to dramatic MAP fluctuations in the Dayanghu wetland. La Niña events and negative-phase intervals of the Pacific Decadal Oscillation may have been responsible for the extreme drought at 4200–4150 cal. yr BP. In summary, we propose a close relationship between MAP and solar forcing, with short-term enhanced solar activity increasing the intensity of the East Asian Summer Monsoon and contributing to increasing decadal variability in the inner tropical Pacific, which ultimately leads to increased precipitation variability in southeast China. The results improve our understanding of the detailed climatic features of the 4.2 ka event. • High-resolution pollen record for ca. 4.2 ka for the Zhejiang region, China. • Pollen-based mean annual precipitation was quantitatively reconstructed. • Long-term droughts tended to occur during 4600–4000 cal. yr BP. • La Niña-dominated ENSO contributed to a catastrophic drought at 4200–4150 cal. yr BP. [ABSTRACT FROM AUTHOR]