Search

An efficient Co-catalyzed hydro-difluoromethylthiolation/hydro-trifluoromethylthiolation reaction of unactivated alkenes was described. Both reactions were conducted at room temperature and a variety of common functional groups such as halogen, ester, aldehyde, enolizable ketone or ester, nitro or cyano group, sulfonate and carbamate were compatible with the reaction conditions. Radical cyclization and radical inhibitor experiments suggested that the reaction proceeds through a free radical process. Image 1 [ABSTRACT FROM AUTHOR]

A BrØsted acid-catalyzed electrophilic trifluoromethylthiolation of indoles under mild conditions is described. The reaction was insensitive to moisture and oxygen, that should allow for easy handling. In addition, the reaction is compatible with a variety of functional groups. [ABSTRACT FROM AUTHOR]