Search

Your search keyword '"Soybel, David I."' showing total 2 results
Start Over Author "Soybel, David I." Topic gastritis Publisher elsevier b.v.
2 results on '"Soybel, David I."'

1. Implications of sustained suppression of gastric acid secretion

Author

Soybel, David I. and Modlin, Irvin M.

Subjects
Gastric acid -- Physiological aspects, Stomach -- Secretions, Gastritis, Health
Abstract

The implications of profound and sustained suppression of acid secretion are of increasing concern. Short-term inhibition of acid secretion by [H.sub.2]-receptor blockade or proton pump inhibition alters the gastric luminal flora and increases the risk of nosocomial pneumonia in critically ill patients who are receiving prophylaxis for stress gastritis. Long-term suppression alters gut flora, carcinogen levels in the gastric lumen, and the hormonal milieu, leading to proliferative changes in the fundic mucosa. Previous reports have noted a significant incidence of gastric malignancies in the achlorhydric environment of atrophic gastritis and pernicious anemia. Concern has also been expressed regarding the possibility of gastric neoplasia that arises after vagotomy and distal gastrectomy. The exact risk of gastric epithelial and endocrine hyperplasia or neoplasia in patients receiving potent antisecretory agents is not yet known, but such risks cannot be dismissed until long-term follow-up studies are available. The relationship between sustained suppression of acid secretion and the proliferation of epithelial and endocrine elements may provide insight into processes that regulate replication and growth of cells in the gastric mucosa.

Published
1992

2. Antioxidant pre-treatment prevents omeprazole-induced toxicity in an in vitro model of infectious gastritis

Author

Kohler, Jonathan E., Blass, Amy L., Liu, Jingjing, Tai, Kaniza, and Soybel, David I.

Subjects
*ANTIOXIDANTS, *OMEPRAZOLE, *GASTRITIS, *GASTROESOPHAGEAL reflux treatment, *FREE radicals, *PHYSIOLOGICAL oxidation, *DRUG toxicity, *LABORATORY rabbits, *THERAPEUTICS
Abstract

Abstract: Omeprazole is a mainstay of therapy for gastroesophageal reflux disease (GERD) and gastritis, and is increasingly used as an over-the-counter remedy for dyspepsia. Omeprazole acts by selectively oxidizing thiol targets in the gastric proton pump, but it also appears to be toxic to the gastric mucosa. We hypothesized that omeprazole toxicity is due to non-specific oxidation of cell structures other than the proton pump, and tested the efficacy of antioxidants to prevent omeprazole-induced toxicity in isolated rabbit gastric glands. Toxicity was measured by uptake and converstion of calcein-AM, following three hours of exposure to omeprazole and a non-selective thiol-oxidant, monochloramine. Intracellular concentration of Zn2+ and the capacity to maintain luminal acidity were monitored using the fluorescent reporters fluozin-3 and Lysosensor DND-160, respectively. Both omeprazole and monochloramine caused marked reduction in cell viability. The toxicity of omeprazole was independent of monochloramine toxicity. The thiol reducing agent dithiothreitol protected gastric glands from injury. The oxidant scavenger Vitamin C also protected, and did not impair the anti-secretory effects of omeprazole. Thus, omeprazole toxicity appears to be oxidative and preventable with antioxidant therapy, including Vitamin C. Vitamin C may be a safe and efficacious addition to treatments requiring the use of PPIs. [Copyright &y& Elsevier]

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results