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Abstract: Background: Growing studies have revealed the association between rs1800497 polymorphism in the dopamine receptor D2 (DRD2) and susceptibility to mood disorder (MD). However, the results remained inconsistent. Methods: To assess the effect of DRD2 rs1800497 polymorphism on MD. We performed a meta-analysis based on eight case-control studies, including a total of 2097 MD cases and 1681 controls. Summary odds ratios (OR) and corresponding 95% confidence intervals (CIs) for DRD2 rs1800497 polymorphism and MD risk were estimated. Results: Our meta-analysis indicated that DRD2 rs1800497 was associated with an increased MD risk, especially in Asians. Moreover, in the subgroup analysis by the type of MD, DRD2 rs1800497 polymorphism was observed to increase risk in BP. Limitations: The results should be treated with caution for lacking of data to perform gene–gene and gene–environment interaction. Conclusions: Our results indicated that polymorphism in DRD2 rs1800497 may play a role in development of MD. [Copyright &y& Elsevier]

To evaluate efficacy of traditional Chinese medicine (TCM) for gastric precancerous lesion (GPL). Literature retrieval was conducted in seven databases from their inception through Dec. 24th, 2018. The Cochrane collaboration, Review Manager (RevMan5.3) and GRADE profiler software were conducted for this meta-analysis. In primary outcomes, results of meta-analysis showed that TCM had superior to current routine pharmacotherapy (RP) in clinical efficacy, Helicobacter pylori (Hp) eradication rate, efficacy under endoscopy, and TCM syndrome efficacy. Meanwhile, no potential publication bias was detected by Begg's and Egger's tests. In secondary outcomes, compared with control groups, experimental groups were more positive effects on improvement of stomach distention, stomachache, and heartburn. Our findings indicated that TCM could have positive effects on GPL. However, further standardized RCTs of rigorous design should be required to obtain more forceful evidence. • Evidence of efficacy of traditional Chinese medicine for gastric precancerous lesion is provided. [ABSTRACT FROM AUTHOR]

Abstract: Background: Cytokines have been implicated in the acute rejection of solid organ transplantation. Many studies have investigated the association between recipient or donor IL-4 polymorphism and acute rejection, with different studies reporting inconclusive results. Methods: We searched PUBMED and EMBASE until June 2012 to identify eligible studies investigating the association between IL-4 polymorphism with acute rejection after solid organ transplantation. Statistical analysis was performed using STATA10.0. Results: A total of 12 studies were included. Pooled ORs suggested 1) no significant association was detected between recipient or donor IL-4 −590C/T polymorphism and acute rejection of solid allograft; 2) no significant association was detected between recipient IL-4 −33C/T polymorphism and acute rejection of solid allograft; 3) when stratified by transplantation type, IL-4 −590C/T polymorphism was associated with acute rejection of liver transplantation (T/T+C/T vs. C/C: OR=0.36, 95%CI=0.14–0.90); 4) significantly decreased risk of acute rejection was detected in recipient IL-4 −590*T-negative/donor T-positive genotype pairs than all other recipient–donor IL-4 −590T/C pairs (OR=0.14, 95%CI=0.03–0.66). Conclusions: Our meta-analysis suggested that recipient IL-4 −590C/T polymorphism was associated with acute rejection of liver transplantation, but nor renal or heart transplantation. It was also suggested that combined recipient IL-4 −590*T-negative/donor T-positive genotype may suffer decreased risk of acute rejection of solid allograft. Further well-designed studies with larger sample size were required to verify our findings, with focus on the association of IL-4 polymorphism with acute rejection in patients with liver transplantation and studies investigating combined recipient–donor genotype. [Copyright &y& Elsevier]