1. The integrated understanding of structural and functional connectomes in depression: A multimodal meta-analysis of graph metrics.
- Author
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Xu, Shu-xian, Deng, Wen-feng, Qu, Ying-ying, Lai, Wen-tao, Huang, Tan-yu, Rong, Han, and Xie, Xin-hui
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DIFFUSION magnetic resonance imaging , *MENTAL depression , *FUNCTIONAL magnetic resonance imaging , *BRAIN , *META-analysis , *BRAIN mapping , *MAGNETIC resonance imaging , *BENCHMARKING (Management) - Abstract
Background: From the perspective of information processing, an integrated understanding of the structural and functional connectomes in depression patients is important, a multimodal meta-analysis is required to detect the robust alterations in graph metrics across studies.Methods: Following a systematic search, 952 depression patients and 1447 controls in nine diffusion magnetic resonance imaging (dMRI) and twelve rest state functional MRI (rs-fMRI) studies with high methodological quality met the inclusion criteria and were included in the meta-analysis.Results: Regarding the dMRI results, no significant differences of meta-analytic metrics were found; regarding the rs-fMRI results, the modularity and local efficiency were found to be significantly lower in the depression group than in the controls (Hedge's g = -0.330 and -0.349, respectively).Conclusion: Our findings suggested a lower modularity and network efficiency in the rs-fMRI network in depression patients, indicating that the pathological imbalances in brain connectomes needs further exploration.Limitations: Included number of trials was low and heterogeneity should be noted. [ABSTRACT FROM AUTHOR]- Published
- 2021
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