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Summary: In this paper, the trends of the annual streamflow and precipitation and cross correlations between them were analyzed in nine large river basins of China during 1956–2005. The results indicate that: (1) the annual mean streamflow decreases in arid and semi-arid regions of north China; however, increasing trends occur in south and Southwest China; (2) the annual streamflow and precipitation exhibit reasonable correlation in nine large river basins except those located in inland areas. The annual streamflow over most areas of China is fed by precipitation; however, the decline in streamflow is faster than the decreases of precipitation since 1970s in the arid and semi-arid regions of north China. The relationship between the annual precipitation and streamflow presents a non-stationary state in north China. This non-stationary relationship is strongly influenced by both human activities and precipitation changes; (3) a significant increase of water use might be the major factor responsible for the steeper decline in streamflow than in precipitation in Haihe River, Yellow River and Songliao River basins in north China. In inland river areas, increase of water use and actual evapotranspiration might result in decline in streamflow although precipitation has an increase tendency. This paper sheds light on the non-stationary relationship between annual precipitation and streamflow and possible underlying causes, which will be helpful for a better understanding of the changes of precipitation and streamflow in China at large scale and in other regions of the world. [Copyright &y& Elsevier]