1. Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation.
- Author
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Silbajoris, Robert, Linak, William, Shenderova, Olga, Winterrowd, Christopher, Chang, Huan-Cheng, Zweier, Jay L., Kota, Anirudh, Dailey, Lisa A., Nunn, Nicholas, Bromberg, Philip A., and Samet, James M.
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ACOUSTIC phenomena in nature , *NANODIAMONDS , *EPITHELIAL cells , *OXIDATION , *NANOSTRUCTURED materials - Abstract
Detonation nanodiamonds (DNDs), a nanomaterial with an increasing range of industrial and biomedical applications, have previously been shown to induce a pro-inflammatory response in cultured human airway epithelial cells (HAECs). We now show that surface modifications induced by air oxidation of DND (AO-DND), including an increase in oxygen content, formation of carboxylic groups associated with the appearance of high negative zeta potential and a decrease in unpaired electron content, are accompanied by a significant loss of bioactivity, as measured by levels of interleukin-8 mRNA in HAEC. These findings are relevant to the identification of chemical determinants and molecular mechanisms of the inhalational toxicity of carbonaceous nanomaterials. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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