1. NIR-II light-responsive biodegradable shape memory composites based on cuprorivaite nanosheets for enhanced tissue reconstruction.
- Author
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Yang, Chen, Zheng, Rui, Younis, Muhammad Rizwan, Shao, Jundong, Fu, Lian-Hua, Zhang, Dong-Yang, Lin, Jing, Li, Zhiming, and Huang, Peng
- Subjects
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NANOSTRUCTURED materials , *SHAPE memory polymers , *MEMORY , *WOUND healing - Abstract
[Display omitted] • A facile strategy was developed for shape memory composite (SMC). • CaSiCu 4 O 10 (CUP) nanosheets exhibited good NIR-II photothermal activity. • SMC with CUP offered remote actuation and enhanced tissue reconstruction. • The release of Cu2+ and SiO 4 4- ions from CUP could accelerate wound healing. Near-infrared (NIR) light-responsive shape-memory composites have shown great potential in various biomedical applications due to their amazing remote actuation property. However, most of them are bioinert and restricted in NIR-I biological window. Here, we developed a new biodegradable NIR-II-responsive shape memory composite by the incorporation of CaSiCu 4 O 10 nanosheets (CUP NSs) into shape memory polymer of poly (D, L-lactide-co-trimethylene carbonate) (PDLLA-co-TMC, denoted as PT). The as-prepared CUP/PT composites possessed outstanding shape memory performance upon low power NIR-II laser irradiation (1064 nm, 0.4 W·cm−2), offering the possibility of deep-tissue applications. Moreover, due to the sustained release of bioactive Cu2+ and SiO 4 4- ions, the composites exhibited strong stimulation of angiogenesis both in vitro and in vivo. Our work demonstrated the promising potential of CUP/PT composites as NIR-II light-responsive biomaterials with enhanced tissue reconstruction ability, especially for wound healing. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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