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The understanding of many physical and engineering problems involves running complex computational models. Such models take as input a high number of numerical and physical explanatory variables. The information on these underlying input parameters is often limited or uncertain. It is therefore important, based on the relationships between the input variables and the output, to identify and prioritize the most influential inputs. One may use global sensitivity analysis (GSA) methods which aim at ranking input random variables according to their importance in the output uncertainty, or even quantify the global influence of a particular input on the output. Using sensitivity metrics to ignore less important parameters is a form of dimension reduction in the model's input parameter space. This suggests the use of meta-modeling as a quantitative approach for nonparametric GSA, where the original input/output relation is first approximated using various statistical regression techniques. Subsequently, the main goal of our work is to provide a comprehensive review paper in the domain of sensitivity analysis focusing on some interesting connections between random forests and GSA. The idea is to use a random forests methodology as an efficient non-parametric approach for building meta-models that allow an efficient sensitivity analysis. Apart its easy applicability to regression problems, the random forests approach presents further strong advantages by its ability to implicitly deal with correlation and high dimensional data, to handle interactions between variables and to identify informative inputs using a permutation based RF variable importance index which is easy and fast to compute. We further review an adequate set of tools for quantifying variable importance which are then exploited to reduce the model's dimension enabling otherwise infeasible sensibility analysis studies. Numerical results from several simulations and a data exploration on a real dataset are presented to illustrate the effectiveness of such an approach. • Global Sensitivity Analysis ranks inputs according to their importance on output. • Random Forests is an efficient non-parametric approach for building meta-models. • Random forests variable importance measure is used to define sensitivity measures. • Provide a comprehensive review paper in sensitivity analysis using random forests. • Focus on connections between random forests and Global Sensitivity Analysis. [ABSTRACT FROM AUTHOR]