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The emerging digital economy has facilitated the digital transformation of the logistics industry toward a standard and collaborative state. The logistics infrastructure has accordingly attracted much attention as the basis for supporting digital economy implementation. Moreover, the initiatives of regional collaborative development, such as in the Greater Bay Area (GBA) of China, have accelerated the integration of logistics infrastructure and operation-level collaboration. Fortunately, the Cyber-Physical Internet (CPI) has created new opportunities for promoting infrastructure integration through the cyber, physical and internet dimensions. However, regional infrastructure integration in the GBA faces various challenges associated with CPI network operations. Thus, a bottom-up approach is proposed to facilitate logistics infrastructure integration in the CPI environment based on the conceptual fusion of computer networks. Considering the fundamental difference in network fusion and operation mechanisms between CPI and computer networks, a CPI-LI2 (logistics infrastructure integration) framework is designed as an integrated solution. Finally, a simulation study is conducted using real-life medical logistics data from the GBA to verify the effectiveness of the CPI-LI2 framework. Experiments show that the framework is well adapted to large-scale logistics networks with dynamically changing links. [ABSTRACT FROM AUTHOR]

Abstract: Alternation of surface markers on monocytes is associated with the development of inflammation. The goals of the present study were to detect CD47 expression on monocytes by flow cytometry and explore its relationship with disease severity and MODS in burned patients. The results show CD47 expression on monocytes from all burned patients (n =21) was lower than that from the healthy population (n =21) for 24 days after burn. There was a significant difference in CD47 expression on monocytes between the patients with differing burn severity in the first 7 days after injury (P <0.05). Considering the relationship between CD47 expression and MODS, we found the CD47 expression on monocytes from patients with MODS was lower (P <0.05) in the first 3 days after injury than that from patients without MODS. In conclusion, diminished CD47 expression on monocytes is associated with burn severity and the occurrence of MODS in burn patients. [Copyright &y& Elsevier]

This study provides new insight for kinematic restoration in the thrust nappe and the effect of tectonic evolution on shale gas preservation was demonstrated in a case study from the Dingshan area in the southeastern Sichuan Basin, southwest China. The uplift process was reconstructed by sandbox experiment, discrete element method, vitrinite reflectance and thermochronology data, including apatite fission track, apatite (U–Th)/He and zircon (U–Th)/He. Thermo-kinematic analysis indicated that from southeast to northwest, the initial uplift time was getting earlier and the erosion increased, while the horizontal displacement decreased during the Alpine stage (Early Cretaceous-Eocene). During the Himalayan stage (Eocene-present time), it was characterized with rapid uplift as a whole. To study dynamic evaluation of shale gas preservation during tectonic evolution, the temperature and pressure evolution were revealed combining fluid inclusion analysis and basin modeling and variation in shale gas content was quantified. Differential uplift caused obvious differences in the process of cooling, pressure decreasing, fracturing and shale gas losing. With moderate uplift (∼3350–3550 m), a few fractures generated in the shale and roof and few gas (∼0.95–1.72 m3/t) diffused laterally. Enormous uplift (∼5350 m) resulted in obvious fractures and massive gas loss (∼3.22 m3/t) by lateral diffusion and vertical dissipation. • Tectonic evolution of thrust nappe revealed by new thermo-kinematic method. • Firstly proposed the burial-hydrocarbon generation-uplift-gas loss evolution of shale. • Dynamic analysis of shale gas preservation and loss during different uplift process. • Evidence for the effect of tectonism on the shale fracturing at a regional scale. [ABSTRACT FROM AUTHOR]