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Abstract: Agro-residue is one of the important biomass resources in China and its efficient utilization is crucial for providing bio-energy, releasing risk of environmental pollution, and enhancing rural incomes. Densification is one of the important utilization routes of agro-residues. The objective of this paper is to explore the development of agro-residue densified fuel in China based on energetics analysis. The energetical property and energy potential of main agro-residues in China were firstly analyzed and then the development of agro-residue densified fuel in every region was evaluated based on energetics analysis. The results show that the main agro-residues in China are good feedstocks as densified fuel and they constitute enormous energy potential for developing densified fuel. However, the situation of every region should be considered for the development of agro-residue densified fuel. The primary energy embodied per unit of useful energy indicates that most of the regions in China are suitable for developing agro-residue densified fuel as it is energetically advantageous compared with coal, whereas only about 25% of regions near coal production locations are not suitable as they are less energetically advantageous. [Copyright &y& Elsevier]

Abstract: China has the abundant agro-residue resources, producing more than 630 million tons of agro-residues in 2006, and amounting to about 20% of total energy consumption in rural areas. Efficient utilization of enormous agro-residues resource is crucial for providing bioenergy, releasing risk of environmental pollution, and increasing farmers’ income. The paper presented the feasibility of densified solid biofuels technology for utilizing agro-residues in China. The output and distribution of agro-residues in recent 10 years, the R&D of briquetting technology, and the market of densified solid biofuels from agro-residues in China have been analyzed. The result indicated that the abundant agro-residue resources can provide the economical and sustainable raw material for densified solid biofuels development in China. The R&D of briquetting technology at present can strongly support the large scale production of densified solid biofuels. With continued improvement and cost reduction of briquetting technology, along with the support of nation energy policy on biomass energy, the market of densified solid biofuels from agro-residues in China will be more fully deployed. Based on the above mentioned key factors, development of densified solid biofuels from agro-residues in China will be promising and feasible. [Copyright &y& Elsevier]

Abstract: Ultrafiltration of Binxian reservoir (near Harbin in China) water to produce drinking water was investigated in this study. Membrane flux declined with temperature coming down. Using coagulation before UF not only increases the permeate flux, but also retards the permeability decline. In comparison to the normal backwashing in which flow is reversed across the membrane once during each backwash cycle, two consecutive backwashing pulses during each cycle is an optimized operation. A chemical cleaning may be required to restore the initial performance of the membrane when the fouling occurs. As for Binxian reservoir water, 0.1% citric acid is a proper cleaning solution. Membrane filtration offers fewer coagulation agents needed and good quality of produced water. [Copyright &y& Elsevier]

• δ18O and δD were gradually changed to positive values from the outlet to the source area. • The monsoon circulation had also been affected TTH, while only affected QML in summer and affected ZMD in June and July. • δ18O in the regions where mainly affected by westerly circulation was lower than that in the southeast coast of China. This study aimed to systematically analyze the characteristic and factors of stable isotope in atmospheric circulation through a fixed-point sampling from April 1, 2016 to October 31, 2018 in the source area of the Yangtze River. The results showed that δ18O and δD were gradually changed to positive values from the outlet to the source area. With the increase in precipitation, the sub-cloud evaporation decreased in a negative exponential function. δ18O in the regions affected by the water vapor sources of the southeastern monsoon were higher than in other regions, and δ18O in the regions mainly affected by the westerly circulation were lower than those in the southeast coast of China. The average evaporation rates of falling raindrops (f) in ZMD, QML, and TTH were 9.53%, 13.14%, and 22.60%, respectively, whereas the average enrichment rates (E) were 10.32%, 15.95%, and 26.30%. Westerly circulation was a long-distance and high airflow, it had significant effects on the atmospheric precipitation in the whole source area of the Yangtze River. The southwest monsoon circulation from the Indian Ocean had also affected the atmospheric precipitation in TTH. However, the monsoon circulation only affected QML in summer, while it only affected ZMD in June and July. Image, graphical abstract [ABSTRACT FROM AUTHOR]

Background: Previous trials of iron supplementation in infancy did not consider maternal iron supplementation.Objective: This study assessed effects of iron supplementation in infancy and/or pregnancy on infant iron status, illnesses, and growth at 9 mo.Methods: Enrollment occurred from December 2009 to June 2012 in Hebei, China. Infants born to women in a pregnancy iron supplementation trial were randomly assigned 1:1 to iron [∼1 mg Fe/(kg · d) as oral iron proteinsuccynilate] or placebo from 6 wk to 9 mo, excluding infants with cord ferritin <35 μg/L. Study groups were pregnancy placebo/infancy placebo (placebo/placebo), pregnancy placebo/infancy iron (placebo/iron), pregnancy iron/infancy placebo (iron/placebo), and pregnancy iron/infancy iron (iron/iron). The primary outcome was 9-mo iron status: iron deficiency (ID) by cutoff (≥2 abnormal iron measures) or body iron <0 mg/kg and ID + anemia (hemoglobin <110 g/L). Secondary outcomes were doctor visits or hospitalizations and weight or length gain from birth to 9 mo. Statistical analysis by intention to treat and dose-response (between number of iron bottles received and outcome) used logistic regression with concomitant RRs and general linear models, with covariate control as applicable.Results: Of 1482 infants randomly allocated, 1276 had 9-mo data (n = 312-327/group). Iron supplementation in infancy, but not pregnancy, reduced ID risk: RRs (95% CIs) were 0.89 (0.79, 0.998) for placebo/iron compared to placebo/placebo, 0.79 (0.63, 0.98) for placebo/iron compared to iron/placebo, 0.87 (0.77, 0.98) for iron/iron compared to placebo/placebo, and 0.86 (0.77, 0.97) for iron/iron compared to iron/placebo. However, >60% of infants still had ID at 9 mo. Receiving more bottles of iron in infancy was associated with better infant iron status at 9 mo but only among iron-supplemented infants whose mothers were also iron supplemented (i.e., the iron/iron group). There were no group differences in hospitalizations or illnesses and no adverse effects on growth overall or among infants who were iron sufficient at birth.Conclusions: Iron supplementation in Chinese infants reduced ID at 9 mo without adverse effects on growth or illness. Effects of iron supplementation in pregnancy were observed only when higher amounts of iron were distributed in infancy. This trial was registered at clinicaltrials.gov as NCT00613717. [ABSTRACT FROM AUTHOR]

• Inclusion of clinical factors improved the dose-based model in predicting temporal lobe injury. • D 0.5cc of 65.06 Gy was the tolerance dose of the temporal lobe. • Reducing D 0.5cc may decrease TLI risk, especially in older patients with advanced T stage. • A nomogram with age, T stage, and D 0.5cc could predict temporal lobe injury precisely. To develop predictive models with dosimetric and clinical variables for temporal lobe injury (TLI) in nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). Data of 8194 NPC patients who received IMRT-based treatment were retrospectively reviewed. TLI was diagnosed by magnetic resonance imaging. Dosimetric factors were selected by penalized regression and machine learning, with area under the receiver operating curve (AUC) calculated. Cox proportional hazards models containing the most predictive dosimetric factor with/without clinical variables were performed. A nomogram was generated as a visualization of Cox regression for predicting TLI-free survival. During median follow-up of 66.8 months (interquartile range [IQR] 54.2–82.2 months), 12.1% of patients (989/8194) developed TLI. Median latency from IMRT to TLI was 36 months (IQR 28–47 months). D 0.5cc (dose delivered to 0.5-cm3 temporal-lobe volume) was the most predictive dosimetric factor (AUC: 0.799). Tolerance dose for 5% and 50% probabilities to develop TLI in 5 years were 65.06 Gy (95% confidence interval [CI]: 64.19–65.92) and 89.75 Gy (95% CI: 87.39–92.11), respectively. A nomogram comprising age, T stage, and D 0.5cc significantly outperformed the model with only D 0.5cc in predicting TLI (C-index: 0.78 vs. 0.737 in train set; 0.775 vs. 0.73 in test set; both P < 0.001). The nomogram-defined high-risk group had worse 5-year TLI-free survival. D 0.5cc of 65.06 Gy was the tolerance dose of the temporal lobe. Reducing D 0.5cc decreased risk of TLI, especially in older patients with advanced T stage. The nomogram could predict TLI precisely and allow individualized follow-up management. [ABSTRACT FROM AUTHOR]

• Full-length genomes of DHAV-1 worldwide were sorted into seven sub-groups. • Full-length genomes of DHAV-3 worldwide were sorted into five sub-groups. • DHAVs identified in China displayed great genetic diversity. • Recombination hotspot of DHAV genome is at the 5′ end and upstream of the capsid coding region. • The highest variability of DHAV polyprotein is at the upstream region of n terminus P-loop. Duck hepatitis A virus (DHAV) is one of key pathogens for duck viral hepatitis, especially in Asian duck industry. Currently, two main genotypes (DHAV-1 and -3) exist. To explore insightfully the evolutionary character, we assessed the available 141 full-length genome sequences of DHAV isolated in 1986–2020 globally and divided DHAV-1 and DHAV-3 into further seven (DHAV-1 a-g) and five (DHAV-3 a-e) sub-clades, respectively. Phylogenetic and phylogeographic network analyses indicated great genetic diversity of DHAV identified in China, where the DHAV-1 cluster and DHAV-3 cluster were linked by virus strain HDHV1-BJ (GenBank ID: FJ157172.1) and Du_CH_LSD_090612 (GenBank ID: JF828995.1) via a long mutational branch and intermediate strains. Several strains previously identified as DHAV-1 according to the partial gene sequences were actually clustered within DHAV-3 in full-length genome-based analysis. Furthermore, we identified 32 recombination events across virus genome with the recombination hotspot at the 5′ end and upstream of the capsid coding region. The highest variability of DHAV polyprotein was shown at the upstream region of the N terminus P-loop region, e.g., amino acids 672–716, followed by the aa 334–359 in the Capsid encoding region. The results presented here provides a robust insight into the genetic exchange patterns of DHAV genomes during the past decades, which may be used to map the evolutionary history and facilitate preventive measures of DHAVs. [ABSTRACT FROM AUTHOR]

• LPC, C/P and N/P of arbors, herbs and shrubs belong to strong variation indicators; • Altitude was also one of the main factors affecting plant functional traits; • Soil factors and leaf functional traits of different types plants respond to each other. Subsequent findings reveal the combination characteristics and spatial patterns of plant functional traits, and their response and adaptation to environmental changes in the Qinghai-Tibet Plateau. We analyzed the variation in characteristics and the influence of environmental factors on leaf functional traits from 78 quadrats in July 2021, using: one-way ANOVA, Tukey's Honest Significant Difference (HSD) post hoc test, Pearson correlation coefficient (r) analysis, and redundancy analysis (RDA) in the Qilian Mountains. Only the leaf carbon content (LCC) of arbors was a weak variation indicator in leaf function traits of different plant types, whereas other leaf function traits including: the LCC of herbaceous plants (herbs) and shrub plants (shrubs), and the leaf nitrogen content (LNC) and carbon to nitrogen (C/N) ratio of arbors were medium variation indicators. The LNC, leaf phosphorus content (LPC), C/N ratio(C/N), C/P ratio(C/P), and N/P ratio (N/P)of herbs and shrubs, and the LPC, C/P, and N/P of arboreal plants (arbors) were strong variation indicators. Altitude was also one of the main factors affecting functional traits of plants in cold regions. Electrical conductivity (EC) and soil phosphorus content (SPC) were the main factors affecting changes in the leaf functional traits of herbs. Soil bulk density (SBD) and Soil salinity (SAL) were the main factors affecting changes in the leaf functional traits of shrubs. Soil nitrogen content (SNC) and soil temperature (ST) were the main factors affecting changes in the leaf functional traits of arbors. [ABSTRACT FROM AUTHOR]

• Similar to herb and shrub, arbor plant shows significant differences with altitude. • LA, LL, LW, LC, and SC showed the same trend among different vegetation types. • There was negative correlation between soil temperature and NBI, ChI, FIv, and SC. Plant functional traits are adaptive traits formed by interactions between plants and the environment. Considering the Three-River Headwaters Region as a case study, this study systematically analyzed the relationship between plant functional traits and environmental factors in cold regions. The results show that there were significant differences in plant functional traits among the different vegetation types (herbs, shrubs, and arbor plants). Leaf traits such as leaf area (LA), leaf length (LL), leaf width (LW), leaf circumference (LC), and shape coefficient (SC) showed the same trends among herbs, shrubs, and arbor plants. The correlation between leaf functional traits of plants in alpine regions shows that the unique growth mode of different plants and their degree of adaptation to alpine environments ultimately determine the leaf functional trait variations. Moreover, there was a negative correlation between soil temperature and the nitrogen balance index (NBI), chlorophyll content (Chl), flavonoid content (Flv), and SC, whereas there was a trend of first increasing and then decreasing relationship between soil temperature, LL (P < 0.05), and LC (P < 0.05). Similar to herb and shrub plants, arbor plants also showed significant differences in altitude in cold regions. There were significant negative correlations between altitude and NBI (P < 0.05), Chl (P < 0.05), Flv (P < 0.05), and anthocyanin content (P < 0.05), whereas LA (P < 0.05), LL (P < 0.05), and LC (P > 0.05) were significantly positively correlated with altitude. Conversely, there was no significant negative correlation between LW and altitude (P > 0.05). We conclude that climate factors play a decisive role in the distribution of plant functional traits at a global scale, whereas land use and disturbances play a major role at a regional scale, and topographic and soil factors determine the distribution of local characteristics. [ABSTRACT FROM AUTHOR]

Farmland shelterbelt system (FSS) in oasis desert ecotones can effectively improve ecosystem services, especially in fragile agricultural areas. However, the spatial-temporal heterogeneity of its ecological effects still needs further clarity, because the interactions are complex and multiple. Understanding this allows us to know the key practical significance of ecological construction and agricultural management. In this study, four typical patterns of FSS (i.e. two lines pattern, TWLP; four lines pattern, FOLP; five lines pattern, FILP; eight lines pattern, EILP) were selected in a desert oasis ecotone in northern China to assess the distributions at vertical (0–100 cm), horizontal (0–3 H) and temporal (May- October) scales of soil properties, vegetation attributes, microclimates and variations of soil moisture storage (SMS) and soil salt contents (C) during the three growing seasons. The results showed that the major difference in soil properties and vegetation attributes of FSSs are the soil particle composition and canopy size, respectively. In FOLP and EILP, the silt contents were 51.6% and 41.5% respectively. The canopy size ranked from the highest to lowest values as follows: FOLP (8.70 m2) > EILP (6.91 m2) > TWLP (4.64 m2) > FILP (4.47 m2). Compared to the control, all patterns of FSSs registered significant effects on microclimate improvement. The FOLP and FILP achieved the same effects as well as EILP, with less spatial costs. Moreover, the variations of SMS and C were mainly different at the vertical scale. As indicated by the Redundancy (RDA) and variation partitioning (VP) analyses, soil properties played a more important role in reserving soil water and controlling soil salinity than vegetation attributes and microclimates, which the independent influence can explain 48.5% of total influence among all factors. Our results provide an efficient theoretical basis for FSS construction and agricultural water management practices. • Farmland shelterbelt system (FSS) can improve ecosystem services. • A spatio-temporal heterogeneity of ecosystem functions in FSSs is observed. • Soil properties play a more important role in controlling soil water content and salinity. • Results provide an efficient theoretical basis for agricultural water management in deserts. [ABSTRACT FROM AUTHOR]

Occurrence and distribution of 15 antibiotics belonging to families of sulfonamides, fluoroquinolones, tetracyclines and chloramphenicols were investigated in water and sediment in Gaoqiao mangrove area, China, using LC-MS-MS. The influence of tidal level and mangrove vegetation on antibiotic residues were examined. The levels of antibiotics were found to be ranged from 0.15 to 198 ng L −1 in water and from 0.08 to 849 μg kg −1 in sediment. No significant difference in concentrations of 15 different antibiotics from water and sediment samples was observed among the high, middle and low intertidal channel. The residues of SMZ, SMTZ, OFL, NOR, ENR, OXY and FLO were significantly higher in Aegiceras corniculatum assemblage than in Avicennia marina assemblage. Although no significant difference in tested antibiotics was found between the surface and bottom sediment, mangrove vegetation can to some extent reduce the accumulation for SMZ, SMTZ, OFL, NOR, CIP, OXY and TET in sediments relative to corresponding bare mudflats, implying that the environmental pollution from antibiotics may be mitigated by mangrove vegetation. Principal components analysis revealed that the terrestrial input and different habitats directly influenced the occurrence and distribution of antibiotics. [ABSTRACT FROM AUTHOR]

Summary Investigation of drought structure in terms of drought onset, termination, and their transition periods as well as drought duration helps to gain a better understanding of drought regime and to establish a reliable drought early warning system. In this study, a Nonparametric Multivariate Standardized Drought Index (NMSDI) combining the information of precipitation and streamflow was introduced to investigate the spatial and temporal characteristics of drought structure in the Yellow River basin (YRB). Furthermore, the correlations between the El Niño-Southern Oscillation (ENSO) events and NMSDI variations were explored using the cross wavelet technique. The results showed that (1) The variations of NMSDI were consistent with those of 6-month SPI (Standardized Precipitation Index) and SSFI (Standardized Streamflow Index), indicating that the proposed nonparametric multivariate drought index was reliable and effective in characterizing droughts. (2) The preferred seasons of drought onset were spring and summer, and winter was the preferred season of drought recovery in the YRB. The long-term average drought duration in the whole basin was nearly 5.8 months, which was clearly longer than the average drought onset and termination transition periods. (3) Overall, the drought structure in terms of drought duration, onset and termination transition periods in the YRB remained stable, and no appreciable change trend was found. (4) ENSO events exhibited a statistically negative correlation with NMSDI variations, suggesting that they showed strong impacts on drought evolutions in the YRB. Although the YRB was selected as a case study in this paper, the approach/indicator can be applied in other regions as well. [ABSTRACT FROM AUTHOR]

It is of importance to investigate the response of agricultural drought to meteorological drought and its influencing factors, which could help better understand drought evolution mechanisms and facilitate agricultural drought monitoring and predictions. As a case study in the Wei River Basin (WRB), China, the heuristic segmentation method was first applied to identify change points of long-term hydrological and metrological conditions for the period of 1960–2007. Then the cross wavelet analysis was utilized to reveal the detailed links between agricultural drought (based on Palmer Drought Severity Index (PDSI)) and meteorological drought (based on Standardized Precipitation Index (SPI)) at the seasonal time scale. The controlling factors governing the agricultural response were then explored through quantitatively examining the corresponding large-scale atmospheric conditions and local-scale land surface characteristics. Results indicate that: (1) the variations of the lag time of agricultural drought in response to meteorological drought is large at the seasonal scale, characterized by fast response in summer and relatively slow response in autumn, and the contrasting response in the time lag is mainly due to the buffering effects of soils; (2) the variations of Arctic Oscillation (AO) was found to have large effects on the lag time, with both positive and negative effects; (3) a negative correlation between the lag time and the parameter w in the Fu’ equation within the Budyko framework was found, implying the potential effects of vegetation cover on the drought propagation from meteorological drought to agricultural drought in the WRB. [ABSTRACT FROM AUTHOR]

Objectives: Drug safety and postmarketing surveillance have become important public health issues in China. This study reviews the relatively new drug safety surveillance system in China and compares it with the systems in the United States and Europe. Methods: An extensive literature review was conducted in the following four areas: 1) the organizational structure of the State Food and Drug Administration (SFDA) in China; 2) the development of an adverse drug reaction (ADR) monitoring system in China; 3) regulatory issues related to drug safety in China; and 4) similarities and differences between drug safety surveillance in China and surveillance in the United States and Europe. Results: The SFDA oversees an extensive network of drug safety “watchdogs,” including the China National Center for ADR Monitoring and 32 regional centers throughout China. China's system has faced a number of recent challenges. It has had to respond quickly to the withdrawal of various high-profile drugs like Vioxx (rofecoxib) and Baycol (cerivastatin) from other markets. Together with China's Ministry of Health, the SFDA has faced several unique drug safety events. Three of those events, involving the injectable form of the heartleaf houttuyinia herb (Yu Xing Cao), Armillarisni A injections, and clindamycin glucose infusions (Xinfu), are discussed. The rapid development of drug safety surveillance in China is manifested in extensive organizational structure, development of large databases, and laws and regulations supporting drug safety. The two major laws are the China Drug Administration Law issued in February 2001 and the Regulation for the Administration of ADR Reporting and Monitoring issued in March 2004. The study also discusses and compares recent developments in drug safety surveillance in the United States and the European Union. These developments will most likely have implications for the Chinese system in the near future. Conclusions: While postmarketing surveillance guidelines are not yet available in China, we fully expect their eventual issuance after adaptation to the particular culture and clinical practices in China. [ABSTRACT FROM AUTHOR]

• Landscape adjacency is a key mechanism of impact of urban expansion on natural areas. • A novel index (Eco-erosion index, EEI) was proposed based on landscape adjacency. • EEI is a useful indicators to assess ecological stress at different scales. • The Yangtze River Delta showed an increasing ecological stress from 1990 to 2010. Urban agglomeration (the spread of cities into large agglomerations) has become the main form of urbanization in China, and natural ecosystems surrounding the urban areas are becoming degraded and fragmented as a result. Although ecological indicators have been widely used to assess the regional ecological stress resulting from urbanization, few of them consider spatial adjacency relationships between urban and natural landscapes. From this perspective a novel ecological indicator, the Eco-Erosion Index (EEI), was developed and applied to assess the regional ecological stress caused by urban agglomeration development across 26 cities in the Yangtze River Delta, China (YRD). We analyzed: i) temporal change in land use and land cover (LULC) and ecosystem services value (ESV) in YRD from 1990 to 2010, ii) spatiotemporal dynamics of EEI of YRD at different scales: provincial, municipal, and 5 km-grid, iii) inter-relationships between EEI and LULC and ESV to explore its effectiveness as an indicator. The results showed that urban agglomeration in YRD has led to increasing regional ecological stress from 1990 to 2010. EEI values increased from 0.197 in 1990 to 0.321 in 2010. The closer to Shanghai City, the greater the EEI values of the cities become. EEI is highly related with LULC and ESV but integrates these two variables as it represents both the spatial occupation and landscape adjacency effects. The EEI values demonstrate some scale effects, and EEI at fine scale provides useful information to guide sustainable urban landscape management. [ABSTRACT FROM AUTHOR]