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As countries worldwide seek to reach net zero emissions within the coming decades, data center sustainability measures are becoming increasingly important as these facilities consume substantial amounts of electricity to support globally expanding digital infrastructure. Yet, local renewable energy production and waste heat utilization are still rarely used in data centers, even though recent high electricity prices have considerably increased the economic value of self-generation and energy efficiency investments. The benefits and cost-effectiveness of data center sustainability measures have also not yet been thoroughly researched in cold-climate regions, where the data center industry is currently growing rapidly. Thus, this paper assesses how solar photovoltaics (PV) and waste heat utilization can effectively be integrated into different cold climate data centers, with a case study analyzing data centers in Finland and northern Japan. The modelled results indicate that solar PV systems can cost-effectively be used to provide renewable electricity to data centers in both Finland and northern Japan, with electricity prices having the largest influence on economic performance. The use of larger external PV systems is shown to be cost-effective at the higher electricity prices seen in 2022, whereas smaller rooftop PV systems and grid electricity provide more economic benefits at 2019 price levels. Selling surplus PV electricity to the grid and using waste heat for district heating is also shown to be effective in data centers located in Finland, whereas battery storage and snow melting are better suited to utilize surplus PV electricity and data center waste heat in northern Japan. [Display omitted] • Solar photovoltaic systems can cost-effectively reduce data center emissions in cold climate countries. • Data center waste heat can provide value in district heating and snow melting applications. • The cost-effectiveness of data center sustainability measures is largely influenced by electricity prices. • The option to sell surplus electricity to the grid incentives larger solar photovoltaic investments in data centers. [ABSTRACT FROM AUTHOR]

Abstract Background and aims Real-world data on treatment patterns in Japanese hyperlipidemia patients with diabetes mellitus (DM) or prior atherosclerotic cardiovascular diseases (ASCVD) are lacking. Methods This is a retrospective, longitudinal cohort analysis of administrative claims data (Japan Medical Data Center [JMDC] and Medical Data Vision [MDV] databases) for patients prescribed a new hyperlipidemia medication between 2014 and 2015. Patients were followed for ≥12 months. Outcomes included prescribing patterns, persistence (discontinuations), and adherence (proportion of days covered). Results Data were analyzed for 11,718 and 27,746 DM, and 4101 and 14,356 ASCVD patients from the JMDC and MDV databases, respectively. Among previously-untreated patients, index prescriptions were primarily for moderate statins in the DM (JMDC: 74.7%, MDV: 77.5%) and ASCVD (JMDC: 75.4%, MDV: 78.5%) sub-cohorts. Combinations were rarely prescribed (≤2.5%). Previously-treated patients were most frequently prescribed combinations in the DM (JMDC: 46.7%, MDV: 53.6%) and ASCVD (JMDC: 49.3%, MDV: 53.3%) sub-cohorts. Intensive statins were rarely used by previously-untreated (≤1%) or previously-treated (≤8%) patients in either sub-cohort. Approximately half of previously-untreated patients discontinued hyperlipidemia therapy within 12 months. Adherence was ≥80% across most drug classes. Conclusions Many Japanese hyperlipidemia patients with DM or ASCVD are prescribed single-agent lipid-lowering therapy. Use of intensive therapy is lower than expected, and is suggestive of under-treatment. The low persistence rates are concerning, and warrant further study. Graphical abstract Image 1 Highlights • This longitudinal cohort study analyzed hyperlipidemia (HL) therapy claims data. • Patients with type 2 diabetes mellitus or cardiovascular disease were included. • Adherence was ≥80% across most drug classes in both cohorts. • 12-month persistence rates were low and variable, and warrant further study. [ABSTRACT FROM AUTHOR]

The Comprehensive Nuclear-Test-Ban Treaty (CTBT) specifies that an overall network of at least 40 International Monitoring System (IMS) stations should monitor the presence of radioxenon in the atmosphere upon its entry into force. The measurement of radioxenon concentrations in the air is one of the major techniques to detect underground nuclear explosions. It is, together with radionuclide particulate monitoring, the only component of the network able to confirm whether an event originates from a nuclear test, leaving the final proof to on-site inspection. Correct and accurate interpretation of radioxenon detections by State Signatories is a key parameter of the verification regime of the Preparatory Commission for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO). In this context, the discrimination between the highly variable radioxenon background generated by normal operations of nuclear facilities and CTBT-relevant events is a challenging, but critical, task. To this end, the radioxenon background that can be expected at IMS noble gas systems must be sufficiently characterized and understood. All activities conducted to study the global radioxenon background are focused on the calibration and performance of the verification system as described in the Treaty. The unique CTBTO noble gas system network is designed to optimally covering the globe. By the end of 2019, 31 systems were put in operation, 25 of which being already certified. It took two decades from the first experimental setup of noble gas system in the field to reach this stage of maturity. In the meantime, it was an urgent need to gain empirical evidence of atmospheric radioxenon concentrations with the full spectrum of characteristics that IMS noble gas systems may be observing. This experience was significantly advanced through temporary measurement campaigns. Their objective was to gain the additional necessary knowledge for a correct understanding and categorization of radioxenon detections. The site selection for these campaigns put emphasis on regions with low coverage by the initially few experimental noble gas systems at IMS locations or where potential interferences with normal background might be observed. Short-term measurements were first initiated in 2008. Sites of potential interest were identified, and campaigns up to few weeks were performed. Based on the findings of these short campaigns, transportable systems were procured by the CTBTO. Longer temporary measurement campaigns were started afterwards and operated by local hosts in different regions of the globe. Site selections were based on purely scientific criteria. Objectives of the measurement campaigns were continually reassessed, and projects were designed to meet the scientific needs for radioxenon background understanding as required for nuclear explosion monitoring. As of today, several thousands of samples have been collected and measured. Spectra of temporary measurement campaigns were (and are still) analysed in the International Data Centre (IDC). As they are not part of the CTBT monitoring system, no IDC product is generated. Analysis results are stored in a non-operational database of the CTBTO and made available, together with raw data, to authorized users of States Signatories through a Secure Web Portal (SWP) and to scientific institutions for approved research projects through a virtual Data Exploitation Centre (vDEC) after signing a cost-free confidentiality agreement (https://www.ctbto.org/specials/vdec). This paper aims at providing an overview of the temporary measurement campaigns conducted by the CTBTO since the very first field measurements. It lays out scientific results in a systematic approach. This overview demonstrates the asset of radioxenon background measurement data that have been collected with a wide variety of characteristics that may be observed at IMS stations. It bears a tremendous opportunity for development, enhancement and validation of methodologies for CTBT monitoring. In 2018, a campaign started in Japan with transportable noble gas systems in the vicinity of the IMS station RN38 in Takasaki. It will be described separately once the measurements are completed. • Monitoring 131mXe, 133Xe, 133mXe and 135Xe as part of the CTBTO verification regime. • Overview of 10 years worldwide radioxenon background measurement campaigns. • Characterization of the background away from/at proximity to nuclear facilities. • Variability of radioxenon observations from routine releases of nuclear facilities. • Challenges in discriminating CTBT-relevant observations from normal releases. [ABSTRACT FROM AUTHOR]