Search

Background There are limited data regarding the relation between serum phosphorus concentration (SPC) and subclinical coronary atherosclerosis in the asymptomatic healthy population without kidney dysfunction. Objectives We aimed to investigate the relation between SPC and characteristics of atherosclerotic plaques and cardiac events according to SPCs using a large cohort of asymptomatic Korean individuals. Methods We evaluated 6329 asymptomatic Korean individuals [mean age: 53.6 ± 7.6 y, 4611 men (72.9%)] without kidney dysfunction and coronary artery disease who voluntarily underwent coronary computed tomography angiography (CCTA) as part of a general health examination. Study participants were stratified into quartiles according to their SPCs (≤3.0, 3.1–3.3, 3.4–3.7, ≥3.8 mg/dL). The degree and extent of subclinical coronary atherosclerosis were evaluated with CCTA. Stenosis of diameter ≥50% was defined as significant. A cardiac event was defined as a composite of all-cause death, myocardial infarction, unstable angina, and coronary revascularization. Results After adjustment for cardiovascular disease risk factors, the risk of any atherosclerotic plaque was significantly higher with increasing SPC quartiles (P  = 0.001). In particular, the risk of calcified plaque increased in the second (OR: 1.27; 95% CI: 1.07, 1.51; P  = 0.006), third (OR: 1.39; 95% CI: 1.17, 1.64; P  < 0.001), and fourth SPC quartiles (OR: 1.50; 95% CI: 1.24, 1.82; P  < 0.001) compared with that in the first quartile. However, there were no significant differences in the adjusted ORs for noncalcified plaque, mixed plaque, or significant stenosis. During a follow-up of median 5.4 y, there was no significant difference in cardiac events between the SPC quartiles. Conclusions In asymptomatic Korean individuals without kidney dysfunction, a high SPC was an independent predictor of calcified plaques without any difference in cardiac events. Further long-term prospective studies are required to validate these results. [ABSTRACT FROM AUTHOR]

Projections indicate increasing coastal hazards in the Yellow Sea region owing to relative sea-level rise. Accordingly, regional studies of such change over the Holocene timescale could be helpful in mitigating these threats. Here, we describe the Holocene record of relative sea-level change in the Gochang-Yeonggwang area of South Korea. We compared this record with that of other sites around the coast of the Yellow Sea, including Bohai Bay (China), the Tando Estuary and Gunsan Bay (South Korea), and sites on the east coast of the South Sea and Toyo-oka Basin, Japan. The findings are based on a multi-proxy study, including lithostratigraphy combined with radiocarbon dating and analyses of grain size distribution, magnetic susceptibility, and geochemistry, which facilitated the generation of 89 paleo-sea-level points reconstructed from 28 borehole cores. The early Holocene transgression was found to start later at Gochang-Yeonggwang than at Gunsan Bay, although the distance between them is only 150 km. This result was inferred from substantial differences in sediment delivery owing to Holocene differences in river basin size, topography, and tectonic context. Before ∼7 ka, the slope and highstands from the predicted mean sea-level models at Bohai Bay, Tando Estuary, and Gochang-Yeonggwang were steeper and lower, respectively, from north to south in the Yellow Sea, approaching the slope of the glacio-eustatic sea-level curve. Therefore, the levering effect of transgression in the early Holocene decreased southward in the Yellow Sea. The slight fluctuation in mean sea-level points of the late Holocene resulted from the formation of storm deposit layers in the coastal area, erosion and redeposition in the channel, and geomorphic effects. A partial difference occurred between the relative sea levels at Gochang-Yeonggwang and Toyo-oka. Future relative sea-level research at the southernmost part of the east coast of the Yellow Sea would further improve understanding of the coastal evolution of the region. • The RSL curve slope at ∼8 ka was the steepest among the Yellow Sea east coast sites. • Highstand on RSL is lower than any other east coast site of the Yellow Sea. • Early Holocene transgression levering effect decreased southern of the Yellow Sea east coast. • RSL in the late Holocene was influenced by glacio-eustatic sea-level change. [ABSTRACT FROM AUTHOR]

Abstract: Environmental changes in wetlands during the last glacial reflect the fluvial sedimentary sequences of South Korea. The stratigraphy of the latest Pleistocene sequences in several fluvial drainage basins includes organic mud layers, intercalated in fluvial deposits, particularly including those on the Soro-ri and Jangheung-ri sites of the Miho River and Nam River, respectively. Research methods included analyses of sedimentary facies, 14C dating, and palynology. The post-last glacial maximum (post-LGM) terrestrial sequences are interpreted as responses to fluctuations in fluvial environments. In general, fluvial sequences display cyclicity, including fluvial channel sand and gravel deposits, organic muds of backswamp origin, and overbank flood-deposited muds with intercalated paleosols. Fluvial sedimentary sequences are interpreted to be associated with backswamp organic muds of last glacial age. The age of formation of the lower organic mud layer on the Sorori site is greater than 36kaBP, and that of the upper organic mud layer ranges from 17 to 12kaBP. Since 18kaBP, at the beginning of the post-LGM period, erosional processes became more pronounced. From about 17–15ka, fluvial depositional processes prevailed, to the end of the last glacial period. The young fluvial sequences, intercalated with organic mud layers, are associated with the late glacial Bølling and Allerød intervals, indicating MIS-1 in Korea. [Copyright &y& Elsevier]

Abstract: Technical research for the assessment of the sand resources in old riverbeds and flood plain deposits involves mechanical, geophysical, geochemical, mineralogical and engineering methods. General properties of sand-rich stream sediments from old riverbeds and flood plain are closely linked to the nature of the bedrock source. However, the particle size of sand-rich sediments is locally more important than the bedrock type in a small basin with a simple bedrock assemblage. Increases in SiO2 concentrations are associated with decreases in the other major element concentrations, resulting from weathering process. SiO2 was strongly correlated with Al2O3 concentrations. SiO2 and Al2O3 act as major components for the understanding of weathering indices of sand-rich stream sediments. Engineering properties are assessed using KS categories. This study indicates a mechanism of sedimentation in connection with the parent rock and gives information on the development of appropriate quality aggregate. [Copyright &y& Elsevier]

Abstract: The clinical implications of WMHs in aMCI are inconclusive. Moreover, clinical interactions between APOE genotypes and WMHs remain unclear. This study was conducted to investigate the relationship between WMHs and cognitive functions and how this relationship interacted with APOE genotype in people with aMCI. This study included a total of 1472 patients with aMCI from the Clinical Research Center for Dementia of South Korea (CREDOS) and divided them into 3 groups according to the severity of WMHs as assessed by visual ratings of brain magnetic resonance images. The associations of WMHs with the various cognitive domains and with APOE epsilon 4 (ɛ4) status were evaluated. After multivariable adjustments, the severity of WMHs was independently associated with semantic/phonemic verbal fluency and Stroop test-color reading, while APOE ɛ4 status was associated with verbal and visual memory-immediate, delayed recall, and recognition. Moreover, there were interaction between WMHs and APOE ɛ4 status in semantic verbal fluency (animal, P =0.033; supermarket, P =0.047)/Stroop test-color reading (P =0.024). WMHs independently deleteriously affected frontal executive functions in aMCI patients, regardless of APOE ɛ4 presence. Furthermore, APOE ɛ4 possession caused a rapid decline in frontal executive functions with the increase in the WMHs severity (vs. absence), suggesting that WMHs and APOE ɛ4 genotypes synergistically contribute to frontal executive dysfunctions in aMCI. [Copyright &y& Elsevier]

Abstract: Group A rotaviruses (RVAs) are agents causing severe gastroenteritis in infants and young animals. G9 RVA strains are believed to have originated from pigs. However, this genotype has emerged as the fifth major human RVA genotype worldwide. To better understand the relationship between human and porcine RVA strains, complete RVA genome data are needed. For human RVA strains, the number of complete genome data have grown exponentially. However, there is still a lack of complete genome data on porcine RVA strains. Recently, G9 RVA strains have been identified as the third most important genotype in diarrheic pigs in South Korea in combinations with P[7] and P[23]. This study is the first report on complete genome analyses of 1 G9P[7] and 3 G9P[23] porcine RVA strains, resulting in the following genotype constellation: G9–P[7]/P[23]–I5–R1–C1–M1–A8–N1–T1–E1–H1. By comparisons of these genotype constellations, it was revealed that the Korean G9P[7] and G9P[23] RVA strains possessed a typical porcine RVA backbone, similar to other known porcine RVA strains. However, detailed phylogenetic analyses revealed the presence of intra-genotype reassortments among porcine RVA strains in South Korea. Thus, our data provide genetic information of G9 RVA strains increasingly detected in both humans and pigs, and will help to establish the role of pigs as a source or reservoir for novel human RVA strains. [Copyright &y& Elsevier]

Abstract: Group A rotaviruses (GARVs) cause severe acute gastroenteritis in children and young animals. Although zoonotic infections with bovine-like G6 and G8 GARVs have been reported in many countries, there is little evidence for reassortment between bovine GARVs and GARVs from heterologous species. The finding of bovine GARVs with the G6 and G8 genotypes in combination with the typical porcine P[7] prompted us to characterize all 11 genes of 30 bovine GARVs isolated from clinically infected calves. By the comparison of the full-length ORF of VP7 and NSP1–5, and the partial VP1–4 and VP6 nucleotide sequences between the 30 Korean and other known strains, three different genome constellations were found. Twenty seven strains showed the G8-P[7]-I5-R1-C1-M2-A1-N1-T1-E1-H1 genotypes, a single strain possessed the G6-P[7]-I2-R2-C1-M2-A1-N2-T1-E2-H1 genotype constellation and 2 strains the G6-P[7]-I2-R2-C2-M2-A3-N2-T6-E2-H3 genotype constellation. The complete genome of a single reference strains for each of these three genotype constellations (KJ25, KJ9-1 and KJ19-2) was determined and analyzed. A detailed phylogenetic analysis revealed a complicated picture, with several reassortments among bovine-like, porcine-like and human-like GARV strains, resulting in several different reassortant strains successfully infecting cattle. [Copyright &y& Elsevier]

Abstract: Since the prevalence of bovine norovirus (BNoV) and their genetic diversity have only been reported in the USA, England, Germany and The Netherlands, this study examined the prevalence and genetic diversity of BNoVs in diarrheic calves in South Korea using 645 diarrheic fecal specimens from calves by RT-PCR and nested PCR assays. Overall, 9.3% of the diarrheic fecal samples tested positive for BNoVs by either RT-PCR or nested PCR, of which 5.9% samples also tested positive for other enteric pathogens including the bovine coronavirus, bovine viral diarrhea virus, bovine torovirus, bovine groups A, B and C rotaviruses, bovine enteric Nebraska-like calicivirus and Escherichia coli. The genetic diversity was determined by direct sequencing of the partial RdRp region of 12 BNoVs detected from the fecal samples by nested PCR. Among the BNoVs examined, one Korean BNoV strain had the highest nucleotide (86.8%) and amino acid (99.1%) identity with the genotype 1 BNoV (GIII-1) strain, while the remaining 11 Korean BNoVs shared a higher nucleotide (88.0–90.5%) and amino acid (93.5–99.1%) identity with the genotype 2 BNoV (GIII-2) strains. The phylogenetic data for the nucleotide and amino acid sequences also demonstrated that one Korean BNoV strain clustered with GIII-1 but the remaining eleven strains clustered with GIII-2. In conclusion, BNoV infections are endemic and there are two distinct genotypes with GIII-2 being the main genotype circulating in the calf population in South Korea. [Copyright &y& Elsevier]