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Background: Increasing rates of cannabis use among emerging adults is a growing public health problem. Intensive longitudinal data can provide information on proximal motives for cannabis use, which can inform interventions to reduce use among emerging adults.Method: As part of a larger longitudinal study, patients aged 18-25 years (N=95) recruited from an urban Emergency Department completed daily text message assessments of risk behaviors for 28days, including daily cannabis quantity and motives. Using a mixed effects linear regression model, we examined the relationships between daily quantity of cannabis consumed and motives (i.e., enhancement, social, conformity, coping, and expansion).Results: Participants were, on average, 22.0 years old (SD=2.2); 48.4% were male, 45.3% were African American, and 56.8% received public assistance. Results from the multi-level analysis (clustering day within individual), controlling for gender, race, and receipt of public assistance, indicated daily use of cannabis use for enhancement (β=0.27), coping (β=0.15), and/or social motives (β=0.34) was significantly associated with higher quantities of daily cannabis use; whereas expansion and conformity motives were not.Conclusions: Daily data show that emerging adults who use cannabis for enhancement, social, and coping motives reported using greater quantities of cannabis. Future research should examine more comprehensive cannabis motives (e.g., boredom, social anxiety, sleep) and test tailored interventions focusing on alternative cognitive/behavioral strategies to address cannabis motives. [ABSTRACT FROM AUTHOR]

• Conducted latent profile analyses of emerging adults' social media use. • Distinguished screen time from engagement and general from alcohol-related. • Various forms of engagement seem to matter more than screen time. • The highest active engagers online might be the most at-risk for alcohol misuse. Nearly all U.S. emerging adults use social media at least daily, and most discuss their offline activities online, including their alcohol misuse. As a result, developing evidence finds a correlation between social media use and offline alcohol drinking, suggesting that social media may be a novel risk factor for alcohol misuse. However, there are conflicting findings about what specific function of social media use is risker – does the amount of time spent online or the types of online activities matter more? Our multidisciplinary team of human–computer interactionists, social workers, and public health scholars aimed to refine our understanding of the association between emerging adult social media use and alcohol misuse. To do so, we conceptualized social media use as a multidimensional construct, examining how much time emerging adults spend online (i.e., screen time) and their different online activities (i.e., social media engagement , such as posting pictures or reacting to posted content [e.g., liking shared pictures]). Taking this conceptualization a step further, we distinguished general online activities (i.e., general social media engagement , such as sharing pictures of food) from those explicitly related to offline alcohol consumption (i.e., alcohol-related social media engagement , such as sharing a video of someone drinking alcohol at a party). Finally, we examined if different levels of these three conceptualizations of social media use were risk factors for alcohol misuse and related negative consequences. We collected survey data from 249 emerging adults on Amazon Mechanical Turk. Using latent profile analyses, we attempted to distinguish the different ways we conceptualized social media use (i.e., screen time from general social media engagement and alcohol-related social media engagement.) We then examined whether significant differences existed between identified profiles and various alcohol-related outcomes in a typical and heavy drinking week. We identified 3-profile solutions for both screen time (low, medium, and high) and general social media engagement (minimum, moderate, and high) and a 2-profile solution for alcohol-related social media engagement (minimal and moderate). When we assessed for alcohol risk, screen time was not related to drinking at all (neither frequency nor quantity), not even for emerging adults who reported using social media almost constantly. However, during a heavy drinking week, those who moderately post alcohol-related content online drank more heavily and had more binge drinking days. Notably, and contrary to previous research, emerging adults who reported high general social media engagement were most at risk for binge drinking and experiencing more alcohol-related negative consequences. Findings underscore the importance of considering various forms of social media engagement – and not screen time – when studying the harms associated with using social media, including offline risk-taking behaviors like alcohol misuse. Results indicate that research, interventions, and clinical practice that target and treat emerging adult alcohol misuse should assess their social media behavior, concentrating on their engagement. This is especially true for the highest general engaging emerging adults who almost constantly post, respond, and react while online; these individuals might be the most at-risk and need support. [ABSTRACT FROM AUTHOR]

Identifying as a 'smoker' has been associated with many cigarette smoking-related behaviors, including less frequent and intense cigarette use. Additional smoking behaviors (e.g., use of cannabis or cigars) also may contribute to self-identification as a 'smoker'. This study compared correlates of identifying as a 'smoker' and measurement strategies for non-daily cigarette consumption among young-adult intermittent and light daily smokers. Using data from Wave 1 of the PATH Study, different measurements of past 30-day non-daily cigarette use were evaluated. Weighted logistic regression models were used to compare associations with self-identification as a smoker among 18-24 year-old intermittent and light daily smokers (n = 1531). Use of other smoked products (combustible tobacco, cannabis) and other documented correlates of smoker identity were evaluated. As frequency of monthly smoking increased, self-identification as a smoker increased (1-5 days = 24%, 6-19 days = 48%, 20-29 days = 78%, light daily smokers = 93%, daily smokers using >5 cigarettes per day = 99%). Self-reported smoking status 12 months ago significantly contributed to current identification as a smoker. Smoking cigars daily or using cannabis in the past 30 days were each positively associated with smoker identity. Different measurement approaches to non-daily cigarette use offer different advantages in terms of interpretability and granularity of information. Compared to daily smokers, non-daily smokers exhibit significant variability in identifying as a smoker, and systematic correlates of smoker identification are apparent. These findings may serve to enhance understanding of non-daily smokers and potential targets for intervention among this growing subpopulation of tobacco users. [ABSTRACT FROM AUTHOR]

Background: Loeys-Dietz syndrome (LDS) is a congenital multisystem disorder affecting the cardiovascular and musculoskeletal system. Limited data have reported neurodevelopmental (ND) issues in LDS.Aims: To determine the extent of ND issues in patients with LDS.Methods: A prospective study was performed of LDS patients or their caregivers. The study included data collected via an online survey of age-specific questions. Standard statistical methods were used for baseline and demographic characteristics, as well as group comparisons.Outcomes: Data were obtained from 67 patients with LDS (54% female). Median age was 14.9 years. Gene mutations included TGFBR1 (39%), TGFBR2 (40%), SMAD3 (7%), and unknown (14%). Motor delays (30%, 18/61) and hypotonia (63%, 37/60) occurred frequently. Physical (62%, 39/62), occupational (41%, 23/56), and speech therapies (34%, 20/58) were common. Feeding issues were common (41%, 23/56). TGFBR1 mutations were more frequent among those with motor delays and feeding issues.Conclusions: Patients with LDS and/or their caregivers report at least one ND problem in most cases, and many require therapies. These data suggest ND disorders should be considered to be part of the phenotype. [ABSTRACT FROM AUTHOR]

Background: The past decade has seen over a four-fold increase in deaths from opioid overdose in the United States. To address this growing epidemic, many localities initiated policies to expand access to naloxone (a drug that reverses the effects of opioids); however, little is known how naloxone access affects opioid use behaviours.Methods: The present qualitative study used semi-structured, in-depth interviews with inpatients at a substance use treatment centre. All patients who met study inclusion criteria (in treatment for opioid use, between the ages of 18 and 40, able to speak and understand English, and had not previously completed an interview with the research team) were invited to participate. Interviews were conducted until thematic saturation was reached (N=20) and covered the participant's naloxone knowledge, access, and attitudes, as well as experience(s) with opioid use and opioid overdose, and their naloxone use in the context of opioid overdose. Thematic content analysis was used to analyze interview transcripts.Results: Five main themes were uncovered during analysis; first, awareness about naloxone, including, content knowledge and source information for naloxone. Naloxone awareness was very common among opioid users; however, depth of knowledge varied; some participants did not make any efforts to have naloxone available, and others felt that it was "just as important as a clean needle." The second theme explored how naloxone access intersects with drug selling. The third theme explored naloxone availability while using, including attitudes about naloxone, occasions with no naloxone availability, when naloxone is "good to have," and when naloxone is a priority for users. The fourth theme examined changes in opioid use behaviours associated with naloxone access. Primarily, participants discussed changing how much heroin they used in a given situation to achieve a bigger high. The final theme explored naloxone behaviours that alter overdose mortality risk, such as how users distinguish when to use naloxone, dis-incentives to naloxone use, and solo opioid use.Conclusion: Results indicate that though naloxone awareness was high, there was great variation in the associated attitudes and practices. Participants generally described naloxone as an important resource, but not all were inclined to carry or use it appropriately. Future research needs to examine why different groups of opioid users access naloxone differently, particularly to identify those at risk for experimental opioid use while carrying naloxone. [ABSTRACT FROM AUTHOR]