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Start Over Author "Anderson, Mark A" Publisher elsevier b.v.
326 results on '"Anderson, Mark A"'

2. Quantitative HBeAg is a strong predictor of HBeAg loss among patients receiving pegylated interferon

Author

Huang, Daniel Q., Shen, Liang, Phyo, Wah Wah, Cloherty, Gavin, Butler, Emily K., Kuhns, Mary C., McNamara, Anne L., Holzmayer, Vera, Gersch, Jeffrey, Anderson, Mark, Yang, Wei Lyn, Ngu, Jing Hieng, Chang, Jason, Tan, Jessica, Ahmed, Taufique, Dan, Yock Young, Lee, Yin Mei, Lee, Guan Huei, Tan, Poh Seng, Muthiah, Mark, Khine, Htet Toe Wai, Lee, Chris, Tay, Amy, and Lim, Seng Gee

Published
2024
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26. Terrestrial carbon isotope stratigraphy of the Eocene–Oligocene transition, Petrockstowe and Bovey basins, Devon, UK.

Author

Chaanda, Mohammed S., Grimes, Stephen T., Jerrett, Rhodri M., Anderson, Mark, Leng, Melanie J., Fitzpatrick, Meriel E., and Price, Gregory D.

Abstract

The terrestrial sediments of the Petrockstowe and Bovey basins in Devon, UK were examined. Their age is considered to be Eocene and Oligocene. The sediments (kaolinitic clays, silts, sands, gravels, and lignites) from both basins were analysed for carbon isotopes of organic material, in conjunction with total organic carbon and palynological analyses used to unravel the type of and provenance of organic matter present. Within the Petrockstowe Basin, the lowermost interval examined shows a palynological distribution dominated by phytoclasts, whilst the upper part of the core is dominated by higher concentrations of palynomorphs (up to 90 %) and an increase in amorphous organic matter consistent (up to 37 %) with a change from sand-filled fluvial channels followed by an ephemeral lake or lake margin setting. Our palynological data from the South John Acres Lane Quarry section, Bovey Basin, show that within the lignites palynomorphs are high again (up to 95 %) consistent with them representing more ephemeral lakes or lake margins periodically exposed with mires. Our palynological data set further allows us to determine that isotope trends are not overly determined by the source of carbon in the basins. Our study suggests that the observed patterns were primarily produced by variations of the isotope ratios of terrestrial atmospheric carbon reservoirs. Even with our less than well constrained biostratigraphical control, the data indicate that the carbon isotope excursions seen in the Eocene and Oligocene could be associated with several transient carbon isotopic shifts (associated with the Paleocene–Eocene Thermal Maximum). Our findings therefore appear to lend support to the surface ocean and atmosphere behaving as coupled reservoirs at this time. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Improving Prostate Cancer Detection With MRI: A Multi-Reader, Multi-Case Study Using Computer-Aided Detection (CAD).

Author

Anderson, Mark A., Mercaldo, Sarah, Chung, Ryan, Ulrich, Ethan, Jones, Randall W., and Harisinghani, Mukesh

Abstract

To evaluate whether addition of a computer-aided diagnostic (CAD) generated MRI series improves detection of clinically significant prostate cancer. Nine radiologists retrospectively interpreted 150 prostate MRI examinations without and then with an additional random forest-based CAD model-generated MRI series. Characteristics of biopsy negative versus positive (Gleason ≥ 7 adenocarcinoma) groups were compared using the Wilcoxon test for continuous and Pearson's chi-squared test for categorical variables. The diagnostic performance of readers was compared without versus with CAD using MRMC methods to estimate the area under the receiver operator characteristic curve (AUC). Inter-reader agreement was assessed using weighted inter-rater agreement statistics. Analyses were repeated in peripheral and transition zone subgroups. Among 150 men with median age 67 ± 7.4 years, those with clinically significant prostate cancer were older (68 ± 7.6 years vs. 66 ± 7.0 years; p <.02), had smaller prostate volume (43.9 mL vs. 60.6 mL; p <.001), and no difference in prostate specific antigen (PSA) levels (7.8 ng/mL vs. 6.9 ng/mL; p =.08), but higher PSA density (0.17 ng/mL/cc vs. 0.10 ng/mL/cc; p <.001). Inter-rater agreement (IRA) for PI-RADS scores was moderate without CAD and significantly improved to substantial with CAD (IRA = 0.47 vs. 0.65; p <.001). CAD also significantly improved average reader AUC (AUC = 0.72, vs. AUC = 0.67; p =.02). Addition of a random forest method-based, CAD-generated MRI image series improved inter-reader agreement and diagnostic performance for detection of clinically significant prostate cancer, particularly in the transition zone. [ABSTRACT FROM AUTHOR]

Published
2023
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40. WED-371 Imdusiran (AB-729) administered every 8 weeks in combination with 24 weeks of pegylated interferon alfa-2a in virally suppressed, HBeAg-negative subjects with chronic HBV infection leads to HBsAg loss in some subjects at end of IFN treatment

Author

Yuen, Man-Fung, Heo, Jeong, Nahass, Ronald G., Wong, Grace Lai-Hung, Burda, Tatiana, Bhamidimarri, Kalyan Ram, Hu, Tsung-Hui, Nguyen, Tuan T., Lim, Young-Suk, Chen, Chi-Yi, Gordon, Stuart C., Holmes, Jacinta, Chuang, Wan-Long, Kohli, Anita, Alkhouri, Naim, Gray, Kevin, Thi, Emily P., Medvedeva, Elina, Eley, Timothy, Ganchua, Sharie C., Iott, Christina, Eill, Elizabeth, Espiritu, Christine L., Anderson, Mark, Fortney, Tiffany, Cloherty, Gavin, and Sims, Karen D.

Published
2024
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42. WED-469 Investigating household hepatitis B transmission using whole-genome sequencing and serological analysis in Kinshasa Province, Democratic Republic of Congo

Author

Morgan, Camille, Ngimbi, Patrick, Ntambua, Sarah, Matondo, Jolie, Mavinga, Jeansy, Tukebana, Bienvenu, Tabala, Martine, Mbonze, Nana, Kashamuka, Melchior, James, Linda, Anderson, Mark, Cloherty, Gavin, Hennelly, Chris, Quick, Josh, Loman, Nick, Kent, Christopher, Wilkinson, Samuel, Waddilove, Elizabeth, Delphin, Marion, Airey, George, Lumley, Sheila, Matthews, Philippa C, Yotebieng, Marcel, Mampunza, Samuel, Parr, Jonathan B., and Thompson, Peyton

Published
2024
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44. Update on Diagnostic Imaging of the Rotator Cuff.

Author

Pierce, Jennifer and Anderson, Mark

Abstract

Understanding the anatomy, injury patterns, and surgical procedures is essential for image interpretation. While direct evaluation of the rotator cuff cannot be made, radiographs of the shoulder provide the initial evaluation of the osseous abnormalities associated with rotator cuff impingement. MR imaging is considered the study of choice for the evaluation of the shoulder because of the comprehensive assessment of both bone and soft-tissue abnormalities. MR can accurately evaluate the size and shape of tendon tears, tendon tear retraction, and tendon and muscle quality. Computed tomography is an excellent modality for the evaluation of osseous detail and detection of gas and calcium deposition; however, conventional CT is much less sensitive for bone marrow edema detection and soft tissue detail of the rotator cuff. Ultrasound can assess the rotator cuff with results similar to MRI, but cannot evaluate osseous structures. [ABSTRACT FROM AUTHOR]

Published
2023
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