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1. RAS is regulated by the let-7 MicroRNA family

Author

Johnson, Steven M., Grosshans, Helge, Shingara, Jaclyn, Byrom, Mike, Jarvis, Rich, Angie Cheng, Labourier, Emmanuel, Reinert, Kristy L., Myller, Rolf, and Slack, Frank J.

Subjects
Biological sciences
Abstract

Micro- RNAs are regulatory RNAs found in multicellular eukaryots, including humans and the overexpression of micro-84 RNA, belonging to the let-7 microRNA family, suppresses the multivulva phenotype of activating let-60/RAS (Reticular Activating System) mutations. The 3' untranslated regions of the human Reticular Activating system contain multiple LCSs, allowing let-7 to regulate RAS expression.

Published
2005

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