21 results on '"Ayatollahi, Seyed Abdulmajid"'
Search Results
2. Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection
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Talebi, Marjan, Khoramjouy, Mona, Feizi, Afsoon, Ali, Zulfıqar, Khan, Ikhlas A., Ayatollahi, Neda Alsadat, Ayatollahi, Seyed Abdulmajid, and Faizi, Mehrdad
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- 2023
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Catalog
3. Attenuation of inflammation in streptozotocin-induced diabetic rabbits by Matricaria chamomilla oil: A focus on targeting NF-κB and NLRP3 signaling pathways
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Saghahazrati, Saeid, Ayatollahi, Seyed Abdulmajid, Kobarfard, Farzad, and Minaii Zang, Bagher
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- 2020
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4. Tsc1/Tsc2 complex: A molecular target of capsaicin for protection against testicular torsion induced injury in rats
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Javdan, Nasim, Ayatollahi, Seyed Abdulmajid, Choudhary, Muhammad Iqbal, Al-Hasani, Safaa, Kobarfard, Farzad, Mokhtarian, Kobra, Khoshmirsafa, Majid, and Ata, Athar
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- 2019
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5. Polymorphisms in the angiotensin I converting enzyme (ACE) gene are associated with multiple sclerosis risk and response to Interferon-β treatment
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Yaeghmaie, Rana, Ghafouri-Fard, Soudeh, Noroozi, Rezvan, Tavakoli, Fatemeh, Taheri, Mohammad, and Ayatollahi, Seyed Abdulmajid
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- 2018
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6. Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism.
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Javdan, Nasim, Ayatollahi, Seyed Abdulmajid, Choudhary, Muhammad Iqbal, Al-Hasani, Safaa, Kobarfard, Farzad, Athar, Ata, and Pazoki-Toroudi, Hamidreza
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THERAPEUTIC use of capsaicin , *SPERMATIC cord torsion , *MTOR protein , *REACTIVE oxygen species , *CELLULAR signal transduction , *THERAPEUTICS - Abstract
Scope Testicular torsion and subsequent release of reactive oxygen species (ROS) can cause infertility in adults. Oxidative stress following testicular torsion plays an important role in the ýonset and development of apoptotic cell death through dysregulation of the cellular signaling pathways. Anti-inflammatory and antioxidant properties of capsaicin, a bioactive composition present in red peppers, has already been exploited for treatment of the cancer and pain relief. In present work, we evaluated the role of the mammalian target of rapamycin (mTOR) in antioxidant effect of capsaicin against reperfusion injury following testicular torsion. Methods Male Wistar rats weighing 200–220 g were randomly assigned into four major groups: (i) a sham operated group, (ii) a testicular torsion (TT) group, (iii) three groups treated with different doses of capsaicin (TT + 100, 500 and 1000 μg/ml Cap), and (iv) three groups of healthy rats treated with different doses of capsaicin (100, 500 and 1000 μg/ml). Western blotting assay was used to examine the anti-apoptotic effects of capsaicin in testicular cells following torsion. H&E and TUNEL methods were used to evaluate testicular morphology and apoptosis activity. Results Compared to control group, phosphorylation of mTOR was significantly increased in the TT groups. Capsaicin administration remarkably decreased the phosphorylation of mTOR at the highest dose (P < 0.05). Capsaicin decreased apoptosis and preserved tubular morphology in testes. Conclusion Our results showed that antioxidant properties of capsaicin minimizes cell death and reperfusion injury following testicular torsion. [ABSTRACT FROM AUTHOR] more...
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- 2018
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7. Association analysis of the GABRB3 promoter variant and susceptibility to autism spectrum disorder.
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Noroozi, Rezvan, Taheri, Mohammad, Movafagh, Abolfazl, Ghafouri-Fard, Soudeh, Sayad, Arezou, Mirfakhraie, Reza, Ayatollahi, Seyed Abdulmajid, Inoko, Hidetoshi, Noroozi, Hanieh, Do, Atieh Abedin, and Soureshjani, Amin Abbasi more...
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Objective Several previous linkage and association studies and an expression analysis have suggested the gamma-aminobutyric acid type A receptor beta3 subunit ( GABRB3 ) gene as an important candidate gene for autism. In addition, polymorphisms in the promoter region of GABRB3 might modulate the expression of this gene. In order to investigate the underlying mechanism of the role of GABRB3 in autism susceptibility, we designed a case-control study to analyze the association of the rs4906902 single nucleotide polymorphism (SNP) in the promoter region of the GABRB3 gene with autism spectrum disorder (ASD) in Iranian patients. Materials & methods The rs4906902 polymorphism was genotyped using the polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) technique. The frequency of the risk allele and its association with disease was examined in 518 patients and 472 control individuals. Result The results demonstrated that the genotype frequencies were in Hardy-Weinberg equilibrium in both the case and the control groups. The results shown that neither allelic frequencies nor genotypic distribution of the rs4906902 was significantly different between autism patients and healthy controls. In conclusion It seems that the GABRB3 gene may influence the Autism susceptibility via a different SNPs in this gene. Also, another independent mechanisms like epigenetic effects should not be ignored when we want to explore the link between GABRB3 and ASD. [ABSTRACT FROM AUTHOR] more...
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- 2018
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8. Quantifying the Impact of Algae Supplement on Blood Pressure: Systematic Review and Meta-analysis of Randomized Controlled Trials.
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Ayatollahi, Seyed Abdulmajid, Asgary, Sedigheh, Ghanbari, Fahimeh, Karimi, Raheleh, Kobarfard, Farzad, Sarfaraz, Sana, Nazim, Urooj, and Mohammadi Pour, Pardis
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The impact of Algae supplements and its extract on blood pressure has not concluded yet. The aim of this systematic review meta-analysis is to evaluate the antihypertensive activity of this group marine organism on human. Alga was used in some studies as capsules (from 500-mg to 8-g) and the follow-up duration changed from 17 days to 9 months. The difference in standardized mean and its corresponding 95% confidence interval (CI) was applied as the effect size of algae supplementation on systolic and diastolic blood pressure. Based on the results, a meta-analysis of 10 studies with baseline effect control demonstrated that there was no difference in the mean systolic blood pressure in the 2 groups SMD (95%CI): -1.05 (-2.85,0.76), but a significant difference in the mean diastolic blood pressure was observed and showed that the mean diastolic blood pressure in the treatment group was lower than the control group SMD(95%CI): -2.23 (-4.35,-0.11). A meta-analysis of 4 studies with no baseline control effect did not show significant results on both blood pressure. The evidence to support this systematic review meta-analysis requires more investigation and future large scale RCT clinical trial to confirm the results. [ABSTRACT FROM AUTHOR] more...
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- 2022
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9. Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway.
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Talebi, Marjan, Sadoughi, Mohammad Mehdi, Ayatollahi, Seyed Abdulmajid, Ainy, Elaheh, Kiani, Roghayeh, Zali, Alireza, and Miri, MirMohammad
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NUCLEAR factor E2 related factor , *CELLULAR signal transduction , *HUNTINGTON disease , *CANNABIDIOL , *AMYOTROPHIC lateral sclerosis - Abstract
Cannabidiol (CBD), a cannabinoid that does not create psychoactive activities, has been identified as having a multitude of therapeutic benefits. This study delves into the chemical properties, pharmacokinetics, safety and toxicity, pharmacological effects, and most importantly, the association between the therapeutic potential of CBD and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. The relationship between Nrf2 and CBD is closely linked to certain proteins that are associated with cardiovascular dysfunctions, cancers, and neurodegenerative conditions. Specifically, Nrf2 is connected to the initiation and progression of diverse health issues, including nephrotoxicity, bladder-related diseases, oral mucositis, cancers, obesity, myocardial injury and angiogenesis, skin-related inflammations, psychotic disorders, neuropathic pain, Huntington's disease, Alzheimer's disease, Parkinson's disease, neuroinflammation, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis. The association between CBD and Nrf2 is a zone of great interest in the medical field, as it has the potential to significantly impact the treatment and prevention of wide-ranging health conditions. Additional investigation is necessary to entirely apprehend the mechanisms underlying this crucial interplay and to develop effective therapeutic interventions. [Display omitted] ● The involvement of Nrf2 in the therapeutic potentials of CBD is a growing interest. ● CBD plays a protective role in cardiovascular dysfunctions, cancers, and neurodegenerative conditions by targeting the Nrf2 signaling pathway. ● The Nrf2 pathway signifies an important mechanism that plays an imperative function in regulating the therapeutic properties of CBD. ● The Nrf2 pathway acts as a mediator of the beneficial effects of CBD in conjunction with other signaling pathways and mechanisms. [ABSTRACT FROM AUTHOR] more...
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- 2023
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10. "Enhancing polyamine enrichment from wheat germs: A study utilizing response surface methodology and liquid chromatography-mass spectrometry".
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Mohajeri, Maryam, Mokhtari, Shaya, Khandan, Maryam, Ayatollahi, Seyed Abdulmajid, Kobarfard, Farzad, and Hudaverdi, Anita
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WHEAT germ , *LIQUID chromatography-mass spectrometry , *INDUCTIVE effect , *RESPONSE surfaces (Statistics) , *SPRAY drying , *POLYAMINES - Abstract
Wheat germ is one of the richest natural sources of polyamines, especially spermidine. Cell proliferation property of polyamines has given them inductive effects in the reduction of a variety of chronic diseases and fertility enhancement. Preparing a polyamine-rich extract powder from wheat germ for use in supplements is the aim of the present study. For the first time, the effects of three independent variables of clean-up replicate (A), extraction time (B), and solid-to-liquid ratio (C) on the response of total spermidine content (Y) were investigated using a central composite design optimizing polyamine enrichment. The optimal extraction conditions were 7 h, 3 clean-up replicates, and 1:4 solid to liquid ratio. This is the first production report of spermidine-enriched powder for encapsulation purposes. To obtain an acceptable rheological property, the polyamine-enriched extract was spray dried together with a selected group of excipients, among which glucose was evidenced as the best choice based on encapsulation properties. [Display omitted] • First study on wheat germ RSM conducted polyamine enrichment in 500 g scale. • Combining clean-up and extraction steps as an enrichment process. • Production of a glucose-polyamine enriched powder for encapsulation. • Polyamine determination from wheat germ by A simplified accurate and valid isocratic LC-MS/MS method. [ABSTRACT FROM AUTHOR] more...
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- 2025
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11. Triterpenoid corosolic acid attenuates HIF-1 stabilization upon cobalt (II) chloride-induced hypoxia in A549 human lung epithelial cancer cells.
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Bahadori, Mir Babak, Vandghanooni, Somayeh, Dinparast, Leila, Eskandani, Morteza, Ayatollahi, Seyed Abdulmajid, Ata, Athar, and Nazemiyeh, Hossein
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PROTEIN metabolism , *HYPOXEMIA , *APOPTOSIS , *BIOLOGICAL assay , *CELL culture , *CELL cycle , *CELL lines , *CHROMATOGRAPHIC analysis , *COBALT , *EPITHELIAL cells , *FLOW cytometry , *GENE expression , *HYDROCARBONS , *LUNG tumors , *MEDICINAL plants , *MOLECULAR structure , *MUTAGENICITY testing , *NUCLEAR magnetic resonance spectroscopy , *POLYMERASE chain reaction , *PLANT roots , *STAINS & staining (Microscopy) , *STATISTICS , *T-test (Statistics) , *TERPENES , *WESTERN immunoblotting , *PLANT extracts , *DATA analysis , *DATA analysis software , *DESCRIPTIVE statistics , *ONE-way analysis of variance - Abstract
Hypoxia-inducible factor-1 is a target for the management of cancer. Here, the anti-proliferation properties of corosolic acid (CA) against A549 human lung epithelial cancer cells in CoCl 2 -induced hypoxia is reported. CA was isolated from the roots of Salvia syriaca based on a bioassay-guided isolation platform and identified by 1D and 2D NMR experiments. Several cytotoxicies and genotoxicity analyses were performed using MTT, DAPI, cell cycle, DNA ladder, and annexin V/PI detection. Cobalt chloride (CoCl 2) was used to stimulate hypoxia. The adaptation of A549 cells to a stimulated hypoxic condition in the presence of CA was evaluated. CA decreased the growth of A549 cells with an IC 50 of 12 μg/mL at 48 h. Also, chromatin condensation and DNA fragmentation were detected as signs of apoptosis occurrence. CA induced ~85% apoptosis and even 1% necrosis. The expression of hypoxia-inducible factor-1 α (HIF-1α), HIF-1β and downstream genes was strongly suppressed in the presence of CA in CoCl 2 -stimulated hypoxia condition. Results indicated that CA has remarkable cytotoxicity against the cancerous cell in hypoxia condition and may be regarded for preparation of new formulations for possible uses as supplement and medicine in cancer therapy. Unlabelled Image • The roots of Salvia syriaca were subjected to bioassay-guided isolation • Triterpenoid corosolic acid (CA) was found to be anti-proliferative compound • CA attenuates HIF-1 stabilization upon CoCl 2 -induced hypoxia in A549 cancer cells • CA has remarkable anti-cancer activity in hypoxia through targeting HIF-1 [ABSTRACT FROM AUTHOR] more...
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- 2019
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12. Thymus spp. plants - Food applications and phytopharmacy properties.
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Salehi, Bahare, Abu-Darwish, Mohammad Sanad, Tarawneh, Amer Hussein, Cabral, Celia, Gadetskaya, Anastassiya V., Salgueiro, Ligia, Hosseinabadi, Tahereh, Rajabi, Sadegh, Chanda, Warren, Sharifi-Rad, Mehdi, Mulaudzi, Rofhiwa Bridget, Ayatollahi, Seyed Abdulmajid, Kobarfard, Farzad, Arserim-Uçar, Dılhun Keriman, Sharifi-Rad, Javad, Ata, Athar, Baghalpour, Navid, and Contreras, María del Mar more...
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THYMES , *CHEMICAL composition of plants , *ANTI-infective agents , *ANTIOXIDANT analysis , *FOOD preservation , *FUNCTIONAL foods - Abstract
Abstract Background Thymus genus has been used since ancient times for their valuable health properties, which could be attributed to their chemical components, especially essential oils (EOs). Among these species, T. vulgaris has a long history of use for different food and medicinal purposes. Scope and approach This paper reviews the chemical composition of Thymus plants EOs, including thyme, describes their antimicrobial and antioxidant properties as well as recent food applications as preservatives. The role of these plants in cancer is also covered, as well as the potential these plants have to manage and treat other diseases. Furthermore, clinical studies are also detailed. Key findings and conclusions Food preservation with naturally occurring compounds is gaining increasing importance due to the consumer demand for safe and high-quality products and to reduce the use of synthetic preservatives. For this purpose, not only thyme but also other thymus plants can be used as such and combined with high-pressure, cold nitrogen plasma, in edible films (active packaging), etc. Moreover, the potential of these plants have to treat several diseases and complications reinforce their use in nutraceuticals and functional foods, but further clinical evidence is required. Highlights • Important applications of Thymus plants in the food industry have been revised. • The hurdle concept for food preservation applications seems promising. • 3 Thymus plants show significant biological properties and beneficial health effects. • Further studies are required to formulate active ingredients based on Thymus plants. [ABSTRACT FROM AUTHOR] more...
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- 2019
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13. A review on the role of LINC00472 in malignant and non-malignant disorders.
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Ghafouri-Fard, Soudeh, Askari, Arian, Hussen, Bashdar Mahmud, Rasul, Mohammed Fatih, Taheri, Mohammad, and Ayatollahi, Seyed Abdulmajid
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THERAPEUTICS , *CELL physiology , *HEART diseases , *ATRIAL fibrillation , *LINCRNA , *ANGIOTENSIN II - Abstract
Long intergenic non-protein coding RNA 472 (LINC00472) has been shown to regulate diverse cellular functions and contribute to the etiology of human disorders. LINC00472 gene is located on 6q13 and has different alternatively spliced transcripts. Expression pattern and function of LINC00472 have been evaluated in different types of cancers and some other disorders, including atherosclerosis, sepsis-induced acute hepatic injury, atrial fibrillation, neuropathic pain, primary biliary cholangitis and sepsis-induced cardiac dysfunction. This lincRNA can serve as a sponge for miR-24–3p, miR-196b-5p, miR‐23a‐3p, miR-93–5p, miR-4311, miR-455–3p and a number of other miRNAs. LINC00472 is able to regulate several pathways, including MEK/ERK, NF-kB, PTEN/PI3K/AKT, and STAT3 signaling pathways. This raises some concerning aspects that need to be investigated further and clarified in relation to diseases. Increasing our understanding of LINC00472's crucial roles will open new doors for creating effective therapeutic approaches against cancer and related diseases. The current study aims at providing an overview of functions of LINC00472 in malignant and non-malignant disorders. [ABSTRACT FROM AUTHOR] more...
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- 2023
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14. A review on the role of SNHG8 in human disorders.
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Ghafouri-Fard, Soudeh, Harsij, Atefeh, Hussen, Bashdar Mahmud, Taheri, Mohammad, and Ayatollahi, Seyed Abdulmajid
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LINCRNA , *NON-coding RNA , *SATELLITE cells , *CEREBRAL ischemia , *MUSCLE cells - Abstract
Small nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA that has physiological roles in epithelial and muscle satellite cells. This lncRNA has been reported to be over-expressed in a variety of cancer cell lines. Its silencing has attenuated tumor growth in animal models of cancers. SNHG8 can be served as a molecular sponge for some miRNAs to regulate their target genes. miR-634/ZBTB20, miR-335–5p/PYGO2, miR588/ATG7, miR-152/c-MET, miR-1270/BACH1, miR-491/PDGFRA, miR-512–5p/TRIM28, miR-149–5p/PPM1F, miR-542–3p/CCND1/CDK6, miR-656–3p/SERBP1, miR-656–3p/SATB1, miR-1270/S100A11 and miR-384/HOXB7 are examples of molecular axes being regulated by SNHG8 in the context of cancer. Moreover, it can affect pathogenesis of atherosclerosis, chronic cerebral ischemia, acute gouty arthritis, ischemic stroke and myocardial infarction through modulation of a number of molecular axes such as SNHG8/miR-384/Hoxa13/FAM3A and miR-335/RASA1 as well as NF-κB signaling pathway. The current review aims at summarization of the role of SNHG8 in diverse human disorders. [ABSTRACT FROM AUTHOR] more...
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- 2023
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15. Occurrence and exposure assessment of aflatoxin B1 in Iranian breads and wheat-based products considering effects of traditional processing.
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Noroozi, Razieh, Kobarfard, Farzad, Rezaei, Mansour, Ayatollahi, Seyed Abdulmajid, Paimard, Giti, Eslamizad, Samira, Razmjoo, Fatemeh, and Sadeghi, Ehsan
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AFLATOXINS , *BREAD , *BAKED products , *FLOUR - Published
- 2022
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16. Circ_CDR1as: A circular RNA with roles in the carcinogenesis.
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Ghafouri-Fard, Soudeh, Khoshbakht, Tayybeh, Hussen, Bashdar Mahmud, Sarfaraz, Sana, Taheri, Mohammad, and Ayatollahi, Seyed Abdulmajid
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CIRCULAR RNA , *BLADDER cancer , *LUNG cancer , *LIVER cancer , *SQUAMOUS cell carcinoma , *STOMACH cancer - Abstract
Circular RNAs are a group of ancient but recently appreciated transcripts that affect carcinogenesis. An example of cancer-related circular RNAs is circ_CDR1as. It is mostly regarded as an oncogenic circular RNA, yet in bladder cancer and glioma it has the opposite effect. In gastric and ovarian cancer, both roles have been reported for this circular RNA. Circ_CDR1as has regulatory effects on miR-1270/AFP, miR-1287/Raf1, miR-7–5p/KLF4, miR-641/HOXA9, miR‐219a‐5p/SOX5, miR-7/HOXB13 and miR-876–5p/MAGE-A molecular axes. miR-7 is the most appreciated interacting miRNA with circ_CDR1as, since its interaction with circ_CDR1as has been validated in liver cancer, lung cancer, colorectal cancer, esophageal carcinoma, gastric cancer, pancreatic cancer, thyroid cancer, oral squamous cell carcinoma, nasopharyngeal carcinoma and osteosarcoma. The present article aims at summarization of the role of circ_CDR1as in neoplasms and its application as a biomarker in human cancers. [ABSTRACT FROM AUTHOR] more...
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- 2022
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17. Contribution of circRNAs in gastric cancer.
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Ghafouri-Fard, Soudeh, Honarmand Tamizkar, Kasra, Jamali, Elena, Taheri, Mohammad, and Ayatollahi, Seyed Abdulmajid
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STOMACH cancer , *EARLY detection of cancer , *TRANSCRIPTOMES , *CIRCULAR RNA , *PATHOGENESIS - Abstract
Gastric cancer (GC) is one of the most commonly diagnosed neoplasms in the world. A number of environmental and lifestyle factors, particularly chronic infection with Helicobacter pylori, have been found to partake in the pathogenesis of GC. The advent of high-throughput genome and transcriptome analysis has enhanced the knowledge about molecular mechanisms of the pathogenesis of GC. However, data regarding the expression of several circRNAs, such as circLMTK2, are not consistent. We explain the role of circRNAs in the development of GC. We searched databases for the newest publications using the terms gastric cancer and circRNA. Each circRNA alteration, downstream targets, its impacts on cancer cells, and the prognostic and diagnostic roles of these circRNAs have been discussed. Taken together, circRNAs can be putative biomarkers in GC and potential targets for the treatment of this cancer. Yet, this field is still in its infancy and needs further experiments for reaching the clinical application. As these transcripts are stable in circulation, they can be used in non-invasive methods of cancer detection and patients' follow-up. [ABSTRACT FROM AUTHOR] more...
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- 2021
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18. Effects of chemotherapeutic agents on male germ cells and possible ameliorating impact of antioxidants.
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Ghafouri-Fard, Soudeh, Shoorei, Hamed, Abak, Atefe, Seify, Mohammad, Mohaqiq, Mahdi, Keshmir, Fatemeh, Taheri, Mohammad, and Ayatollahi, Seyed Abdulmajid
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GERM cells , *CANCER chemotherapy , *GENITALIA , *CISPLATIN , *FERTILITY preservation - Abstract
Treatment of cancer in young adults is associated with several side effects, particularly in the reproductive system. Detrimental effects of chemotherapy on the germ cells depend on many factors including primary semen parameters, the way of drug administration, the kind and dose of chemotherapeutic regimens, and the phase of spermatogenesis during the time of drug administration. Lack of appropriate fertility preservation treatments particularly in the affected children necessitates the introduction of methods to amend the harmful effects of chemotherapeutic agents on male germ cells. Several studies have assessed the toxic effects of chemotherapeutic agents in rodent models and tested a number of antioxidants to evaluate their possible impact on the preservation of sperm cells. In the present manuscript, we describe the effects of the mostly investigated chemotherapeutic drugs in this regard i.e., cisplatin, doxorubicin, paclitaxel, 5-fluorouracil, and cyclophosphamide. As several in vivo and in vitro studies have shown the impact of antioxidants on chemotherapy-induced damage of sperms, we also describe the protective effects of antioxidants in this regard. [ABSTRACT FROM AUTHOR] more...
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- 2021
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19. The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways.
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Ghafouri-Fard, Soudeh, Shoorei, Hamed, Khanbabapour Sasi, Ali, Taheri, Mohammad, and Ayatollahi, Seyed Abdulmajid
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QUERCETIN , *GENE expression , *HERBAL teas , *STAT proteins , *NEURODEGENERATION , *DIABETES , *CELL cycle - Abstract
Quercetin is a flavonoid existing in different herbs, fruits, seeds, nuts and tea. It has beneficial effects on human health through mediating antioxidant activities, immune-modulatory impacts and regulating metabolic pathways. These effects are most probably induced through modulation of activity of signaling pathways and expression of genes. Several in vitro studies have verified anti-proliferative effects of quercetin and its effect on expression of apoptotic genes and cell cycle-related genes. Moreover, through modulation of a number of proteins such as NF-kB, PARP, STAT3, Bax, Bcl-2, COX2, and cytokines, quercetin has beneficial effects in neurodegenerative disorders, liver diseases and diabetes. PI3K/AKT is the mostly linked pathway with beneficial effects of quercetin. In the current manuscript, we explain the impact of quercetin on expression of genes and function of cellular signaling cascades in different contexts. [ABSTRACT FROM AUTHOR] more...
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- 2021
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20. Emerging role of circular RNAs in breast cancer.
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Ghafouri-Fard, Soudeh, Hussen, Bashdar Mahmud, Taheri, Mohammad, and Ayatollahi, Seyed Abdulmajid
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CIRCULAR RNA , *BREAST cancer , *RNA-binding proteins , *NON-coding RNA - Abstract
Circular RNAs (cirRNAs) are generally considered as non-coding RNAs which can act as molecular sponges for miRNAs, exert regulatory roles in transcription or splicing, and interplay with RNA binding proteins. These single-stranded transcripts can affect tumor growth, the metastatic ability of cancer cells, stemness properties, and resistance to therapeutic options. Recent investigations have shown the crucial effects of circrNAs in the evolution of breast cancer. Signature of circRNAs in breast cancer samples has been mostly assessed through microarray-based methods revealing up-regulation of some circRNAs such as circ-TFF1, circACAP2, circ-TFCP2L1, hsa_circ_0000519, circDENND4C, circPLK1 and circRNA_069718, while down-regulation of other circRNAs such as hsa_circ_0000375, circYap, hsa_circ_0025202, circTADA2A-E6, circASS1 and circRNA_BARD1 in breast cancer samples. Mechanistically, these transcripts mainly affect breast cancer tumorigenesis via serving as sponges for miRNAs. In the current manuscript, we explore the results of researches that appraised the role of circRNAs in breast cancer. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
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21. Medicinal plants used in the treatment of tuberculosis - Ethnobotanical and ethnopharmacological approaches.
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Sharifi-Rad, Javad, Salehi, Bahare, Stojanović-Radić, Zorica Z., Fokou, Patrick Valere Tsouh, Sharifi-Rad, Marzieh, Mahady, Gail B., Sharifi-Rad, Majid, Masjedi, Mohammad-Reza, Lawal, Temitope O., Ayatollahi, Seyed Abdulmajid, Masjedi, Javid, Sharifi-Rad, Razieh, Setzer, William N., Sharifi-Rad, Mehdi, Kobarfard, Farzad, Rahman, Atta-ur, Choudhary, Muhammad Iqbal, Ata, Athar, and Iriti, Marcello more...
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MULTIDRUG-resistant tuberculosis , *MYCOBACTERIUM tuberculosis , *MYCOBACTERIA , *TUBERCULOSIS , *MEDICINAL plants , *ALTERNATIVE medicine , *CLINICAL trials , *MULTIDRUG resistance - Abstract
Tuberculosis is a highly infectious disease declared a global health emergency by the World Health Organization, with approximately one third of the world's population being latently infected with Mycobacterium tuberculosis. Tuberculosis treatment consists in an intensive phase and a continuation phase. Unfortunately, the appearance of multi drug-resistant tuberculosis, mainly due to low adherence to prescribed therapies or inefficient healthcare structures, requires at least 20 months of treatment with second-line, more toxic and less efficient drugs, i.e. , capreomycin, kanamycin, amikacin and fluoroquinolones. Therefore, there exists an urgent need for discovery and development of new drugs to reduce the global burden of this disease, including the multi-drug-resistant tuberculosis. To this end, many plant species, as well as marine organisms and fungi have been and continue to be used in various traditional healing systems around the world to treat tuberculosis, thus representing a nearly unlimited source of active ingredients. Besides their antimycobacterial activity, natural products can be useful in adjuvant therapy to improve the efficacy of conventional antimycobacterial therapies, to decrease their adverse effects and to reverse mycobacterial multi-drug resistance due to the genetic plasticity and environmental adaptability of Mycobacterium. However, even if some natural products have still been investigated in preclinical and clinical studies, the validation of their efficacy and safety as antituberculosis agents is far from being reached, and, therefore, according to an evidence-based approach, more high-level randomized clinical trials are urgently needed. • Tuberculosis is a preventable and curable infectious disease, one of the top 10 causes of death worldwide. • Multi-drug-resistant tuberculosis causes an urgent need for new drugs to reduce the global burden of tuberculosis. • Medicinal plants have been and continue to be used in traditional healing systems around the world to treat tuberculosis. • An evidence-based approach to anti-tuberculosis medicinal plants is missing; more randomized clinical trials are needed. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
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