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• We studied the moderating effect of PPAR CC genotype on the association of serum C-reactive protein (CRP) level and ischemic stroke (IS). • Participants with PPAR CG or GG genotype CRP and IS were not statistically significantly associated, but in participants with PPAR CC genotype, the association of CRP and IS was significant. The aim of this study was to evaluate the moderating effect of peroxisome proliferator activated receptor-γ (PPAR-γ) gene variants on the association of serum C-reactive protein level (CRP) and ischemic stroke (IS). A total of 114 patients with IS and 135 healthy controls were included. After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, body mass index and previous therapy with antihypertensive and/or statins, PPAR- γ had statistically significant moderating effect on association of serum CRP level and IS in patients younger than 60. In participants with PPAR CG or GG genotype level of CRP and IS were not statistically significantly associated (OR = 1.00; 95% CI 0.90–1.10; p = 0.933), but in participants with PPAR CC genotype, the association of serum CRP level and IS was significant (OR = 1.67; 95% CI 1.21–2.31; p = 0.002). In patients with PPAR CC genotype the association of serum CRP level and IS was significant. [ABSTRACT FROM AUTHOR]

• We studied the effect of Hp genotypes on ischemic stroke and atherosclerosis in males and females. • Presence of hypertension, HDL, CRP, age and male gender increased the risk of stroke. • Genotype Hp2-2 was statistically significantly associated with ischemic stroke. • We can point to the Hp 2–2 genotype as genetic risk factor for prediction of atherosclerosis in patients with IS. Ischemic stroke (IS) is multifactorial disease and therefore different genes and proteins play a role in its development. Haptoglobin (Hp) removes free hemoglobin and protects from iron-induced oxidative damage, inflammatory response, atherosclerosis and cerebrovascular diseases. The aim of this study was to investigate Hp genetic variants in patients with carotid atherosclerotic lesions and IS. A total of 121 subjects with IS participated in the study, 81 male and 40 female. Among 121 patients with IS, 79 had diffuse atherosclerotic plaques and stenosis. Hp genotype was statistically significantly associated with CDFI neck carotid artery stenosis findings (p = 0.006). Patients with Hp1-2 genotype had statistically significantly larger odds for atherosclerotic changes compared to those with Hp1-1 genotype, as well as those with Hp2-2 genotype. This study has shown an association of the Hp2-2 genotype and atherosclerosis in patients with IS, indicating Hp2-2 genotype as a genetic biomarker for precision medicine and personalized healthcare. [ABSTRACT FROM AUTHOR]