1. Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection.
- Author
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Iwasaki, Jua, Smith, Wendy-Anne, Siew-Kim Khoo, Bizzintino, Joelene, Guicheng Zhang, Cox, Des W., Laing, Ingrid A., Le Souëf, Peter N., Thomas, Wayne R., and Hales, Belinda J.
- Abstract
Background: Asthma exacerbations are associated with human rhinovirus (HRV) infections, and more severe exacerbations are associated with HRV-C. We have previously shown that the HR C-specific antibody response is low in healthy adult sera and the most of the antibody to HRV-C is cross-reactive with HRV-A. Objectives: To compare the antibody response to each HRV species in asthmatic and nonasthmatic children in whom the type of HRV infection was known. Methods: Total and specific IgG
1 binding to HRV viral caps protein antigens of HRV-A, -B, and -C were tested in the plasma from nonasthmatic children (n = 47) and children presenting the emergency department with asthma exacerbations (n = 9 HRV, found in most of the children at the time of their exacerbation (72%), was analyzed using molecular typing. Results: Asthmatic children had higher antibody responses to HRV. The titers specific to HRV-A, and to a lesser extent -HRV-B, were higher than in nonasthmatic controls. The species-specific responses to HRV-C were markedly lower than titers to HRV-A and HRV-B in both asthmatic and nonasthmatic children (P < .001). The titers both at presentation and after convalescence were not associated with the HRV genotype detected during the exacerbation. Conclusions: The higher total anti-HRV antibody titers of asthmatic children and their higher anti-HRV-A and -B titers of show their development of a heightened antiviral immune response. The low species-specific HRV-C titers found in all groups, even when the virus was found, point to a different and possibly less efficacious immune response to this species. [ABSTRACT FROM AUTHOR]- Published
- 2014
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