1. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
- Author
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Trofatter, James A., MacCollin, Mia M., Rutter, Joni L., Murrell, Jill R., Duyao, Mabel P., Parry, Dilys M., Eldtidge, Roswell, Kley, Nikolai, Menon, Anil G., Pulaski, karen, Haase, Volker H., Ambrose, Christine M., Munroe, David, Bove, Catherine, Haines, Jonathan L., Martuza, Robert L., MacDonald, Marcy E., Seizinger, Bernd R., Short, M. Priscilla, Buckler, Alan J., and Gusella, James F.
- Subjects
Neurofibromatosis -- Genetic aspects ,Tumor suppressor genes -- Identification and classification ,Biological sciences - Abstract
The identification of a candidate gene for neurofibromatosis 2 (NF2), a dominantly inherited disorder characterized by the occurrence of bilateral schwannomas and other central nervous system tumors such as multiple meningiomas, is reported. Previous studies have suggested the inactivation of a tumor suppressor gene in choromosome 22q12 as a potential cause of the disorder. The candidate NF2 gene encodes a 587-amino acid protein which is related to the membrane-organizing extension spike protein-ezrin-radixin family of proteins that link cytoskeletal proteins with proteins in the cell membrane.
- Published
- 1993