1. Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study
- Author
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Maxim Noeparast, Maryam Noparast, Mathijs Christiaan Goossens, Cleo Goyvaerts, Maya Hites, Gil Verschelden, Frédéric Cotton, Maïlis Lauwers, Charlotte Michel, Internal Medicine, Laboratory of Molecular and Medical Oncology, Medical Oncology, Basic (bio-) Medical Sciences, and Laboratory of Molecullar and Cellular Therapy
- Subjects
Male ,medicine.medical_specialty ,Immunology ,AUROC, Area under the receiver operating characteristic curve ,COVID-19/blood ,chemistry.chemical_element ,Zinc ,BMI, Body mass index ,Zinc/blood ,infectious diseases ,SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 ,Article ,Interquartile range ,Internal medicine ,ARDS, Acute respiratory distress syndrome ,medicine ,Immunology and Allergy ,Humans ,Prospective Studies ,CRS, Cytokine release syndrome ,Prospective cohort study ,Aged ,Pharmacology ,Inflammation ,Cytokine Release Syndrome/blood ,cHIS, COVID-19-associated hyperinflammatory syndrome ,business.industry ,SARS-CoV-2 ,CI, Confidence interval ,COVID-19 ,IQR, Interquartile range ,Middle Aged ,medicine.disease ,Hospitalization ,Cytokine release syndrome ,ICU, Intensive care unit ,chemistry ,Cohort ,Zinc deficiency ,Biomarker (medicine) ,cHIS ,Observational study ,Female ,Cytokine Release Syndrome ,business - Abstract
Zinc deficiency is associated with impaired antiviral response, cytokine releasing syndrome (CRS), and acute respiratory distress syndrome. Notably, similar complications are being observed during severe SARS-CoV-2 infection. We conducted a prospective, single-center, observational study in a tertiary university hospital (CUB-Hopital Erasme, Brussels) to address the zinc status, the association between the plasma zinc concentration, development of CRS, and the clinical outcomes in PCR-confirmed and hospitalized COVID-19 patients. One hundred and thirty-nine eligible patients were included between May 2020 and November 2020 (median age of 65 years [IQR = 54, 77]). Our cohort's median plasma zinc concentration was 57 µg/dL (interquartile range [IQR] = 45, 67) compared to 74 µg/dL (IQR = 64, 84) in the retrospective non-COVID-19 control group (N = 1513; p
- Published
- 2021