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• A flexible wildfire risk management framework is presented. • Optimal solutions are elusive because trade-offs are ubiquitous. • Solutions are sensitive to the addition of new values, like smoke health costs. • Unmitigated climate change threatens the effectiveness of prescribed burning. • We need flexible, risk-based approaches to fire management. Fire management aims to change fire regimes. However, the challenge is to provide the optimal balance between the mitigation of risks to life and property, while ensuring a healthy environment and the protection of other key values in any given landscape. Incorporating cost-effectiveness and climate change impacts magnifies this task. We present an objective framework for quantitative comparison of the risk mitigation potential of alternative fuel treatment scenarios in south-eastern Australia. There is no single optimal strategy for all values in a given region, nor for any individual value in all regions. Trade-offs are required and cost-effectiveness is highly sensitive to the addition of management values. Climate change is likely to decrease prescribed burning effectiveness and increase total costs, therefore a rethink of best practice is required. Our study highlights the need for flexibility in the development and implementation of fire management strategies, which is something that risk-based approaches can provide. We discuss prospects of extending our framework to values for which we currently lack robust quantitative information and issues of compatibility with Aboriginal cultural burning and by implication other approaches that do not stem from within the prevailing fire management paradigm. [ABSTRACT FROM AUTHOR]

Abstract: Previous studies have shown that the overexpression of tropomyosins leads to isoform-specific alterations in the morphology of subcellular compartments in neuronal cells. Here we have examined the role of the most abundant set of isoforms from the γ-Tm gene by knocking out the alternatively spliced C-terminal exon 9d. Despite the widespread location of exon 9d-containing isoforms, mice were healthy and viable. Compensation by products containing the C-terminal exon 9c was seen in the adult brain. While neurons from these mice show a mild phenotype at one day in culture, neurons revealed a significant morphological alteration with an increase in the branching of dendrites and axons after four days in culture. Our data suggest that this effect is mediated via altered stability of actin filaments in the growth cones. We conclude that exon 9d-containing isoforms are not essential for survival of neuronal cells and that isoform choice from the γ-Tm gene is flexible in the brain. Although functional redundancy does not exist between tropomyosin genes, these results suggest that significant redundancy exists between products from the same gene. [Copyright &y& Elsevier]