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Résumé: Objectif: Comparer les résultats thérapeutiques de deux groupes de patients, adultes et enfants, traités pour un carcinome du nasopharynx. Patients et méthodes: Trois cents soixante-dix-sept patients atteints d’un carcinome du nasopharynx ont été irradiés entre 1993 et 2007. Parmi eux, 69 étaient âgés de moins de 20ans. Deux cent soixante-huit patients ont reçu une chimiothérapie néoadjuvante ou concomitante. Résultats: Les probabilités de survie globale et de survie sans progression de tout le groupe à cinq ans étaient respectivement de 67 % et 59,4 %. Celles de survie globale à cinq ans étaient respectivement de 66 % et 64 % (p =0,17) dans le groupe enfants et adultes, celles de survie sans progression à cinq ans de 66 % et 57 % (p =0,17). Les rechutes étaient plus fréquentes chez les adultes (1,4 % contre 14 %), mais les rechutes métastatiques étaient plus fréquentes chez les enfants. La toxicité tardive était plus marquée chez les enfants et représentée essentiellement par la xérostomie, sans différence significative. Conclusion: Les résultats thérapeutiques étaient meilleurs dans le groupe des enfants malgré la fréquence des formes localement évoluées, sans atteindre le seuil de signification. L’association de radiothérapie et de chimiothérapie pourrait expliquer nos résultats thérapeutiques. [ABSTRACT FROM AUTHOR]

Abstract: Primary epidural cervical non-hodgkin''s low-grade lymphomas is exceptional. We report a 43-year-old woman admitted for a total functional disability of the four limbs. Magnetic resonance imaging revealed a cervical epidural mass C2–C3. A laminectomy was performed. The histological study revealed a small cells lymphoma. The patient underwent chemotherapy and radiotherapy. There was a favourable evolution. She is in complete remission with a follow-up of two years. We review literature to describe epidemiological, clinical and therapeutic features with evolutive aspects in primary epidural non-hodgkin''s lymphomas. [Copyright &y& Elsevier]

Abstract: Jarosite precipitation is a very important phenomenon that is observed in many bacterial cultures. In many applications involving Acidithiobacillus ferrooxidans, like coal desulphurization and bioleaching, it is crucial to minimize jarosite formation in order to increase efficiency. The formation of jarosite during the oxidation of ferrous iron by free suspended cells of A. ferrooxidans was studied. The process was studied as a function of time, pH and temperature. The main parameter affecting the jarosite formation was pH. Several experiments yielded results showing oxidation rates as high as 0.181–0.194g/Lh, with low jarosite precipitation of 0.0125–0.0209g at conditions of pH 1.6–1.7 with an operating temperature of 35°C. [Copyright &y& Elsevier]

Abstract: Purpose. – 1/ To evaluate the incidence of hypothyroidism following radiotherapy in the management of breast and nasopharyngeal carcinomas, 2/ to define the role of a systematic post therapeutic screening. Patients and methods. – From January 1996 through March 2001 a systematic evaluation of the clinical and the biological thyroid function was performed on a cohort of 84 patients that received supraclavicular irradiation. Selected patients had either a mammary (37 cases) or a nasopharyngeal (47cases) carcinoma. Initial work up included thyroid inspection and palpation, and biological tests: serum FT4 and TSH levels, radioimmunochemistry, completed by dynamic thyroid stimulation, using TRH, in case of border line low T4 or isolated high TSH levels. Tests were repeated every three months the first year, and then every six months. Replacement therapy with L Thyroxin was administered in case of hypothyroidism. Results. – All selected patients had a normal function initially. With a mean two years follow up (1–5 years), 24 patients (29%) experienced hypothyroidism, half of whom (13 cases) being purely biological. Five patients (11%), with a nasopharyngeal carcinoma, presented also with associated pituitary failure. Clinical symptoms were minor or mild in all cases. Hypothyroidism was detected at a mean 21 months follow up. In 2 patients, hypothyroidism disappeared spontaneously within 6 months. Possible predictive factors were evaluated: age of the time of radiation, gender, percentage of irradiated thyroid, total dose, dose per fraction, tumour type and chemotherapy. Only age appeared significantly correlated with thyroid dysfunction (range: 10-30 years, P =0.002). Conclusion. – Hypothyroidism is a frequent and certainly underestimated complication following radiotherapy of the neck. In such patients, a systematic clinical and biological evaluation every three months the first year, and then every six months until five years is recommended. [Copyright &y& Elsevier]