1. Chicken Egg Yolk Antibodies (IgYs) block the binding of Multiple SARS-CoV-2 Spike protein variants to human ACE2
- Author
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xinglin Zhang, Tian Jingjing, Xiaohong chen, Li Yong, Jinsong Xie, Wei Shuangshi, Wang Hongmei, Meng Qinglin, Liu Xiaomei, Ding Shaohua, Nong Yu, Chen Yezhou, pingju Ge, and Duan Shengbao
- Subjects
0301 basic medicine ,food.ingredient ,viruses ,Short Communication ,Mutant ,Immunology ,Immunoglobulins ,Biology ,medicine.disease_cause ,Virus ,03 medical and health sciences ,0302 clinical medicine ,food ,Yolk ,IgY ,medicine ,Chicken Egg Yolk Antibodies ,Potency ,Immunology and Allergy ,Animals ,Humans ,skin and connective tissue diseases ,neutralizing agent ,Pandemics ,Spike protein variants ,Coronavirus ,Pharmacology ,SARS-CoV-2 ,fungi ,Spike Protein ,COVID-19 ,virus diseases ,Virology ,Antibodies, Neutralizing ,Egg Yolk ,In vitro ,body regions ,030104 developmental biology ,030220 oncology & carcinogenesis ,Mutation ,Spike Glycoprotein, Coronavirus ,biology.protein ,Angiotensin-Converting Enzyme 2 ,Antibody ,Chickens ,Protein Binding - Abstract
The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.
- Published
- 2020